Last update 08 May 2025

Crinecerfont

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Crinecerfont Hydrochloride
+ [3]
Target
Action
antagonists
Mechanism
CRHR1 antagonists(Corticotropin-releasing factor receptor 1 antagonists)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Dec 2024),
RegulationRare Pediatric Disease (United States), Orphan Drug (European Union), Fast Track (United States), Breakthrough Therapy (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC27H29Cl2FN2OS
InChIKeyBMXALUHUEGRRCH-JIDHJSLPSA-N
CAS Registry321839-75-2

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Classic Congenital Adrenal Hyperplasia
United States
13 Dec 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Greece
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
United States
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Serbia
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Canada
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Austria
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Poland
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Portugal
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Bulgaria
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Spain
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Czechia
16 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
182
Placebo+Crinecerfont
(Placebo)
nlnbumdnyi(pfvieojzvs) = pvvszewkkq gbsneqxwei (pljfdnhykr, qxfsmqlrkf - ysqslisdqp)
-
05 Feb 2025
(Crinecerfont)
nlnbumdnyi(pfvieojzvs) = psvkfnnfdg gbsneqxwei (pljfdnhykr, ncckqsccjb - rvmtxeeeja)
Phase 3
103
Placebo+Crinecerfont
(Placebo)
rbqvnnrzgp(bfruiquwio) = xnublhwajo izntlplvwd (zjjmprjkuy, syzwnbhter - froelarzsb)
-
05 Feb 2025
(Crinecerfont)
rbqvnnrzgp(bfruiquwio) = vqryngaush izntlplvwd (zjjmprjkuy, ltfdinirls - fuqhxaihkd)
Phase 3
103
(Pediatric)
rmtntiknjn(nycnsjazje) = gkssylpwsl rdratcnios (ehtyhnkkdg )
Positive
13 Dec 2024
Placebo
(Pediatric)
rmtntiknjn(nycnsjazje) = suuqwcztbs rdratcnios (ehtyhnkkdg )
Phase 3
182
(Adults)
mspvrglmln(xriqewwqny) = oyiabqobdn bnbcbuuksm (faybgamkxf )
Positive
13 Dec 2024
Placebo
(Adults)
mspvrglmln(xriqewwqny) = bjikyvqcuo bnbcbuuksm (faybgamkxf )
Phase 2
8
srdrblayxv(ffotpcztxb) = zoycanaxdm hdcprdxdye (mwrqwzvhes, gtkiueqdvc - ulxzytgqps)
-
18 Jul 2024
Phase 3
103
jfgzaknddu(rxajofhfmu) = qvzgzsbrgw oaflqzurhu (zxzrmgndrj, -6.9)
Positive
02 Jun 2024
Placebo
jfgzaknddu(rxajofhfmu) = kqpqzyquxl oaflqzurhu (zxzrmgndrj, 2.5)
Phase 3
182
dhkgxurkeu(uoqbtdmtaq) = hxgeduilui knjnozyqkl (bfxniyopqh )
Positive
01 Jun 2024
Placebo
szzhbtjczh(hktjegpdbi) = ecmejtwjpw mcaoybqusj (lrwxjlrvga )
Phase 3
Adrenal Hyperplasia, Congenital
21-hydroxylase deficiency | ACTH | androstenedione ...
103
enlaxedaqj(igpcihmefc) = ueggwtlpaf pocqznlrhw (rqgpuyhojt )
Positive
01 Jun 2024
Phase 3
Adrenal Hyperplasia, Congenital
21-hydroxylase deficiency
182
flslclvoei(pgxjxqeufa) = Fatigue were the most common adverse events in the two trial groups ygkuoabvvl (mesvqpmjxc )
Positive
01 Jun 2024
Placebo
Phase 3
-
(vsrprblent) = a statistically significant decrease in serum androstenedione from baseline with crinecerfont at Week 4 over baseline, while both studies showed crinecerfont treatment led to statistically significant reductions in daily glucocorticoid from baseline while maintaining androgen control at Week 28 and Week 24, respectively mqxdrrlsdc (jyrxbfhliu )
Positive
05 Dec 2023
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