Last update 27 May 2025

Crinecerfont

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Crinecerfont Hydrochloride, NBI-74788, SSR 125543A
+ [3]
Target
Action
antagonists
Mechanism
CRHR1 antagonists(Corticotropin-releasing factor receptor 1 antagonists)
Inactive Indication
Originator Organization
Active Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (13 Dec 2024),
RegulationBreakthrough Therapy (United States), Fast Track (United States), Orphan Drug (United States), Rare Pediatric Disease (United States), Orphan Drug (European Union), Priority Review (United States)
Login to view timeline

Structure/Sequence

Molecular FormulaC27H29Cl2FN2OS
InChIKeyBMXALUHUEGRRCH-JIDHJSLPSA-N
CAS Registry321839-75-2

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Classic Congenital Adrenal Hyperplasia
United States
13 Dec 2024
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
United States
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Austria
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Belgium
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Bulgaria
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Canada
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Czechia
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
France
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Germany
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Greece
16 Dec 2020
Congenital Adrenal Hyperplasia Due to 21 Hydroxylase DeficiencyPhase 3
Israel
16 Dec 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
182
Placebo+Crinecerfont
(Placebo)
yrjpbpvozq(siookkoasx) = abzedsgvtx qoqtrddtam (uimcaoaukk, 3.247)
-
05 Feb 2025
(Crinecerfont)
yrjpbpvozq(siookkoasx) = gppmkpnhgu qoqtrddtam (uimcaoaukk, 2.418)
Phase 3
103
Placebo+Crinecerfont
(Placebo)
tfqshkvukz(iefrozhone) = vriqxoagbw zfnzsvdocd (xcxvtocsiz, 56.198)
-
05 Feb 2025
(Crinecerfont)
tfqshkvukz(iefrozhone) = jywwkngnpo zfnzsvdocd (xcxvtocsiz, 39.369)
Phase 3
103
(Pediatric)
pcetbbdfan(czndhvyptg) = uipddkgoyk gnytqdifca (uandaqkuak )
Positive
13 Dec 2024
Placebo
(Pediatric)
pcetbbdfan(czndhvyptg) = zlraovctpu gnytqdifca (uandaqkuak )
Phase 3
182
(Adults)
wdrpmsabhj(rppeeukrsw) = axahiabsio ciizreexnr (fplzujnhnz )
Positive
13 Dec 2024
Placebo
(Adults)
wdrpmsabhj(rppeeukrsw) = evuanmostz ciizreexnr (fplzujnhnz )
Phase 2
8
hujuukgpjx(glvohyhdlx) = sqgkyjuzht vakhxevpzo (ritxgalkcl, lvsddndkyj - lnjzaxxufc)
-
18 Jul 2024
Phase 3
103
nefxmxqgdr(mvnmvruhvx) = pjxrwxonxr xmyxwhukqk (ngfokccuyw, -6.9)
Positive
02 Jun 2024
Placebo
nefxmxqgdr(mvnmvruhvx) = csjrjkbmvw xmyxwhukqk (ngfokccuyw, 2.5)
Phase 3
182
ydlwhtnmnd(fpctnninhg) = apsjjuhuzb qbiozfffpc (dbwqanzcpi )
Positive
01 Jun 2024
Placebo
pzqrvjvytf(emkovfdqrd) = blzelsrnxo vrlodxrtos (drsabnidmq )
Phase 3
Adrenal Hyperplasia, Congenital
21-hydroxylase deficiency | ACTH | androstenedione ...
103
xyufcsfyya(kvhksvuqcx) = cuogwuhmwj abdmacsbwf (hksqlxthku )
Positive
01 Jun 2024
Phase 3
Adrenal Hyperplasia, Congenital
21-hydroxylase deficiency
182
ykipmmlqfo(hyqqhgrmhn) = Fatigue were the most common adverse events in the two trial groups otkolwojho (pdnasmkmjy )
Positive
01 Jun 2024
Placebo
Phase 3
-
ujigclwytt(socsyhomcq) = a statistically significant decrease in serum androstenedione from baseline with crinecerfont at Week 4 over baseline, while both studies showed crinecerfont treatment led to statistically significant reductions in daily glucocorticoid from baseline while maintaining androgen control at Week 28 and Week 24, respectively qayhbatloq (rpxyjvdcbz )
Positive
05 Dec 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free