Cagrilintide

Plainsboro, New Jersey, US and Bagsværd, Denmark, 29 October 29 2026 – Novo today announced that new data from its obesity portfolio will be presented across 26 abstracts at ObesityWeek® 2026, taking place November 14–17 in Washington, D.C., US. The presentations span real-world treatment experience with the Wegovy ® pill and injection, including data from telehealth settings; new analyses from the investigational CagriSema REDEFINE program, and research on investigational semaglutide injection in children ages 6 to under 12. 1-8 “Obesity is a complex disease, and people living with obesity can have different experiences and treatment needs at different stages of life,” said Martin Holst Lange, chief scientific officer and executive vice president, Research & Development at Novo. “At ObesityWeek®, we will share findings across several key areas, including: investigational CagriSema; real-world treatment experience with oral and injectable Wegovy®; and investigational semaglutide injection in children ages 6 to under 12. Studying treatment options across different settings, formulations, outcomes, and dosing regimens can strengthen understanding of obesity and help inform progress in line with Novo's commitment to lasting health.” REDEFINE clinical program (CagriSema) highlights include: Data on investigational CagriSema in adults with overweight or obesity include the primary results of REDEFINE 9, which tested low doses of CagriSema. In addition, several post-hoc analyses from the pivotal REDEFINE 1 trial are being presented, including an investigation of changes in weight-related quality of life. 1,2 Wegovy ® real-world outcomes and preference study highlights include: Treatment preference among older adults OPTIC study analyses evaluated differences in obesity medication profile preferences among adults 65 and older and younger than 65. 3 Food noise and weight outcomes in telehealth Two real-world studies evaluated outcomes in adults with overweight or obesity using the Ro telehealth platform: OCTANE analyses characterized adults initiating oral semaglutide for weight management, including treatment-naïve patients, and assessed weight outcomes, food noise, and patient-reported outcomes at 3 months. 4,5 The SIGNAL analysis assessed changes in food noise, using the validated RAID-FN scale, and weight among treatment-naive adults with overweight or obesity initiating Wegovy® injection through 6 months of follow up. 6 Treatment experience with a digital support program Analysis from the SWEEP study of Novo’s digital patient support program examined self-reported weight-related outcomes and patient experience among people starting Wegovy® pill. 8 STEP Young highlights include: Full results from the study that evaluated once-weekly investigational semaglutide injection in combination with a reduced-calorie diet and increased physical activity in children ages 6 to under 12 years old with obesity. 7 Full Novo abstracts to be presented at ObesityWeek® 2026 (November 14–17, Washington, D.C.), featuring data on the investigational medicine CagriSema as well as investigational uses of semaglutide: Symposium: Novo poster and oral presentations: CagriSema Wegovy® (semaglutide injection and tablets) Other investigational treatments CagriSema is not approved in the United States or anywhere else. Safety and efficacy are not established, and there is no guarantee that this investigational medicine will become commercially available for the uses under clinical investigation. Investigational semaglutide injection is not approved in the United States for use in children under the age of 12. About CagriSema CagriSema is being investigated by Novo as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program). CagriSema is a fixed-dose combination of a long-acting amylin analog, cagrilintide and a GLP-1 receptor agonist, semaglutide. About obesity Obesity is a serious, chronic, progressive, and complex disease that requires long-term management. 9 - 11 One key misunderstanding is that this is a disease of just a lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off. 9 - 11 Obesity is influenced by a variety of factors, including genetics, social determinants of health, and the environment. 1 2 , 1 3 Novo is the global healthcare company that believes lasting health starts now. For over a century, we’ve combined leading scientific expertise with a deep understanding of people’s lives. We develop treatments and support that help millions of people make progress they can see, feel and sustain now and in the future. Every day, over 67,000 employees around the world advance our purpose to drive change for lasting health. Through our partnerships, programmes and investments, we’re working to prevent disease, expand access to treatments and reduce our environmental impact to help even more people live healthier lives. In the United States, Novo has a 40-year presence, is headquartered in New Jersey and employs approximately 10,000 people. For more information, visit novonordisk.com and novonordisk-us.com and follow us on Instagram , LinkedIn , TikTok , Facebook , X and YouTube . Contacts for further information WEGOVY®, NOVO NORDISK, NOVO, and the Apis Bull Logo are trademarks owned by Novo Nordisk A/S. © 2026 Novo Nordisk All rights reserved. US26SEMO01951 October 2026 References

Plainsboro, New Jersey, US and Bagsværd, Denmark, 28 October 2026 - Novo Nordisk today announced that 12 new abstracts on semaglutide real-world and clinical data will be presented at the American Association for the Study of Liver Diseases congress, The Liver Meeting® 2026, from November 5-9 in Denver, Colorado. “MASH often goes unrecognized and undiagnosed, allowing liver damage to progress over time. Earlier diagnosis and treatment are needed,” said Martin Holst Lange, chief scientific officer and executive vice president, Research & Development at Novo. “The data we are presenting at AASLD include results from real-world studies of semaglutide 2.4 mg and post-hoc analyses of people with MASH without obesity as well as studies investigating efruxifermin, which all deepen our understanding of MASH within our portfolio.” Key Presentations: PLATINUM-Truveta study was a retrospective cohort analysis using de-identified electronic health records that compared the effectiveness of semaglutide 2.4 mg and resmetirom on liver enzymes and cardiometabolic markers in patients with MASH treated in routine clinical practice. This study assessed changes in liver enzymes, body weight, HbA 1c , and other cardiometabolic measures at three and six-month timepoints. Full findings will be presented during a poster session on Friday, November 6, from 13:00–14:00. The study was selected as a Poster of Distinction, a designation given to the top 10% of submitted posters. 1 Additional presentations include a real-world retrospective analysis from the RHODIUM-2 study , examining changes in liver enzymes and cardiometabolic markers among patients with MASH who initiated semaglutide 2.4 mg compared with those who did not. 2 Other research will explore healthcare resource use in MASLD and ALD, and awareness and perceptions of MASLD and MASH among healthcare professionals and people at risk for or living with these conditions. 3–6 Real-world study data can provide valuable insights into how treatments work outside of controlled clinical trial settings. Real-world data analyses also have several limitations; while associations can be demonstrated, causal relationships cannot be definitively established. Results may reflect potential unmeasured confounding, the relatively recent approval of both treatments limited follow-up duration, and electronic medical record data may be subject to coding inaccuracies. Also being presented are clinical trial data from a post-hoc analysis of the phase 3 ESSENCE trial in people with a BMI below 27 and research examining the burden of MASH. 7 An oral presentation will take place on Sunday, November 8, from 11:45–12:00. Exploratory post-hoc analyses are hypothesis generating, and further work investigating the clinical validity of these results would be of value. The research to be presented at The Liver Meeting ® 2026 reflects Novo’s leadership in advancing the understanding of optimal screening, diagnosis, and management of MASH and other serious chronic conditions. Summary of presentations Accepted data at The Liver Meeting ® 2026 include the following poster and oral presentations. Accepted abstracts include preliminary data that may be subject to change in the final published manuscripts. Dates and times of the presentations can be found on the AASLD website. AASLD poster and oral sessions Semaglutide 2.4 mg Cross-product (investigational) MASH disease-area sessions Efruxifermin (investigational) About PLATINUM-Truveta PLATINUM-Truveta was an observational, retrospective cohort study that used de-identified electronic medical record data from the Truveta database across 30 US health systems from June 2021 through March 2026. Adults with MASH who initiated semaglutide 2.4 mg (n=2,873) or resmetirom (n=2,285) were included. Changes from baseline in ALT, AST, body weight, HbA 1c , platelets, triglycerides, HDL, and LDL were assessed at three and six months. Patients with prior use of semaglutide or resmetirom, cirrhosis or other chronic liver diseases were excluded, and treatment persistence was required at each time point. To reduce confounding, generalized estimating equations with inverse probability of treatment weighting were applied. 1 About RHODIUM-2 RHODIUM-2 was an observational, retrospective study that used de-identified electronic medical record data from the Truveta database across 30 US health systems from June 2021 through March 2026. Adults with MASH were grouped according to whether they initiated semaglutide 2.4 mg (n=2,479) or did not initiate semaglutide (n=70,702). Changes from baseline in ALT, AST, body weight, HbA 1c , and other cardiometabolic measures were assessed at 3, 6, and 12 months. Patients with cirrhosis or other liver disease etiologies and those treated with GLP-1 receptor agonists or resmetirom within six months before start of first treatment were excluded. To control for confounding, generalized estimating equations to account for within patient correlation, and inverse probability of treatment weighting was applied. 2 About the ESSENCE trial ESSENCE is an ongoing phase 3 trial evaluating the effect of once-weekly subcutaneous semaglutide 2.4 mg in adults with MASH with moderate-to-advanced liver fibrosis (stage F2 or F3 † ). It is a two-part trial in which 1,197 participants were randomized 2:1 to receive semaglutide 2.4 mg or placebo, on top of standard of care, for 240 weeks. 8 In part 1, the objective was to demonstrate that treatment with semaglutide 2.4 mg improves liver histology at 72 weeks compared with placebo, based on biopsy sampling from the first 800 randomized patients. In part 2, which is ongoing, the primary objective is to demonstrate that treatment with semaglutide 2.4 mg lowers the risk of liver-related clinical events compared to placebo in adults with MASH and moderate-to-advanced liver fibrosis at 240 weeks. 9 About metabolic dysfunction-associated steatohepatitis (MASH) MASH is a serious, progressive, metabolic disease affecting the liver, which can be fatal if not managed properly. 10 More than 250 million people live with MASH, 11 and the number of individuals in advanced stages of the disease is expected to increase over 160% from 2015 to 2030. 12 Of those living with overweight or obesity, more than one in three also have MASH. 13 And of those currently living with MASH, more than 40% have type 2 diabetes, and more than 8 in 10 also live with obesity. 14 People living with MASH often have many other health-related comorbidities, 15 such as cardiovascular disease, which is the leading cause of death in people with MASH. 16 , 17 MASH is largely a silent disease due to few and unspecific symptoms in its early stages, 10 where nearly 90% of people with MASH remain undiagnosed. 17 Once MASH progresses to late stages, there is increased mortality and morbidity, including potential for cirrhosis, liver cancer, and need for liver transplant. 18, 19 About semaglutide 2.4 mg in metabolic dysfunction-associated steatohepatitis (MASH) Semaglutide 2.4 mg is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) FDA-approved under accelerated approval to treat adults with MASH with moderate-to-advanced liver scarring (fibrosis), but not with cirrhosis of the liver, in conjunction with a reduced calorie diet and increased physical activity. 20 This accelerated approval is based on improvement of MASH and liver scarring (fibrosis). 20 Continued approval for this indication may be contingent upon the verification and description of clinical benefit in a confirmatory trial. 20 Novo is investigating semaglutide 2.4 mg in the ongoing ESSENCE phase 3 trial, evaluating the effect of once-weekly subcutaneous semaglutide 2.4 mg in adults with MASH with moderate-to-advanced liver scarring (fibrosis) (consistent with stage F2 or F3 † ). 20 It is important to note that semaglutide 2.4 mg injection has a Boxed Warning for possible thyroid tumors, including cancer, and should not be used in those with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN 2). The most common side effects of semaglutide include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, changes in skin sensations, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and hair loss. 20 Novo is the global healthcare company that believes lasting health starts now. For over a century, we’ve combined leading scientific expertise with a deep understanding of people’s lives. We develop treatments and support that help millions of people make progress they can see, feel and sustain now and in the future. Every day, over 67,000 employees around the world advance our purpose to drive change for lasting health. Through our partnerships, programs and investments, we’re working to prevent disease, expand access to treatments and reduce our environmental impact to help even more people live healthier lives. In the United States, Novo has a 40-year presence, is headquartered in New Jersey and employs approximately 10,000 people. For more information, visit novonordisk.com and novonordisk-us.com and follow us on Instagram , LinkedIn , TikTok , Facebook , X and YouTube . Contacts for further information _______________________ References