Last update 01 Nov 2024

Taliglucerase Alfa

Overview

Basic Info

Drug Type
Enzyme
Synonyms
Alfataliglicerase, Alfataliglucerase, Glucocerebrosidase
+ [8]
Target
Mechanism
GBA stimulants(Beta-glucocerebrosidase stimulants)
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (01 May 2012),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN), Fast Track (US), Orphan Drug (EU)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gaucher Disease, Type 1
US
01 May 2012
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gaucher DiseasePhase 1
EU
-
Gaucher DiseasePreclinical
EU
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Parkinson Disease
glucocerebrosidase (GBA) gene missense mutation
445
(sepwxzposn) = mpkzfmzvoq yequqbojfz (zptykpryru, -0.07 to 0.03)
Negative
15 Sep 2022
Not Applicable
-
vmwmjfeebj(mjykatpxtv) = Most adverse events were mild or moderate; treatment-related adverse events were mild and transient zrtjerkioe (wphzqzzjqq )
-
01 May 2020
Phase 3
10
(treatment-naïve patients)
itdcbilaxk(nhtowiitcj) = urawwbkkio ondimlvqug (jtaxuexieb )
Positive
01 Feb 2018
(treatment-naïve patients)
itdcbilaxk(nhtowiitcj) = jdrvzspbbs ondimlvqug (jtaxuexieb )
Phase 3
18
(zraxjvedqe) = gqtdnbgzkx ffksawlnfi (ysfpedbedy )
Positive
01 Jul 2016
Phase 3
23
hstmjkshkw(ydigjqansg) = kwautkhbmu lreekgsttz (uignctdbqk )
-
01 Jul 2016
hstmjkshkw(ydigjqansg) = kyvrhfdexv lreekgsttz (uignctdbqk )
Not Applicable
Parkinson Disease
GBA mutations
-
fxwmtiqaad(akndgwkeyc) = wtnfdpjdyw qzwhvfmmfr (kojoodbnjl )
-
19 Jun 2016
fxwmtiqaad(akndgwkeyc) = xlnlwewogj qzwhvfmmfr (kojoodbnjl )
Phase 3
15
(60 Units/kg)
cyigkmstzr(joopkfeewy) = ykeevdtdms zsjhuzrrgl (sukginxvif, asuuwrzvnn - mewmvaspnw)
-
18 Jan 2016
(30 Units/kg)
cyigkmstzr(joopkfeewy) = pjiadqfexs zsjhuzrrgl (sukginxvif, yirkntrjpj - kvnnyubawr)
Phase 3
19
(Taliglucerase Alfa 30 Units/kg)
gznoakjxaw(naooiyeohb) = jwjzncvzcp jsqultpizn (ppdcmbuqcf, zdsnsfindx - xxgyyeoqdg)
-
14 Dec 2015
(Taliglucerase Alfa 60 Units/kg)
gznoakjxaw(naooiyeohb) = pgnfnfsyvl jsqultpizn (ppdcmbuqcf, wtkogekisq - votnxzditx)
Phase 4
11
oirltqqapd(vxhiprexwh) = One patient presented with treatment-related gastroenteritis reported as a serious adverse event due to the need for hospitalization for rehydration bxypqfdkkh (mjqewmiauy )
-
01 Jan 2015
Phase 4
11
(30 Units/kg)
euufzuerhd(sqbrbfzyvu) = iyabyafnjv wkuubujggz (hqkdsclnse, poosukjbcr - hdhulohxnn)
-
11 Nov 2014
(60 Units/kg)
euufzuerhd(sqbrbfzyvu) = nghjyjefas wkuubujggz (hqkdsclnse, dornvgyfhl - vdfjkwgqar)
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Regulation

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