Last update 29 May 2025

Paroxetine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Paroxetine betaciclodextrin, Paroxetine Hydrochloride Hydrate, Paroxetine Hydrochoride
+ [19]
Target
Action
inhibitors
Mechanism
SERT inhibitors(Serotonin transporter inhibitors)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H21ClFNO3
InChIKeyGELRVIPPMNMYGS-RVXRQPKJSA-N
CAS Registry78246-49-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Premenstrual Dysphoric Disorder
United States
28 Aug 2003
Panic
Japan
22 Sep 2000
Generalized anxiety disorder
United States
25 Jun 1997
Stress Disorders, Post-Traumatic
United States
25 Jun 1997
Depressive Disorder
China
01 Jan 1995
Depressive Disorder, Major
United States
29 Dec 1992
Obsessive-Compulsive Disorder
United States
29 Dec 1992
Panic Disorder
United States
29 Dec 1992
Phobia, Social
United States
29 Dec 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anxiety DisordersPhase 2
Sweden
01 Nov 2004
Parkinson DiseasePhase 2
United States
01 Jun 2003
Depressive Disorder, Treatment-ResistantClinical
United States
01 Dec 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
27
Placebo+Oxycodone
(Treatment A: Placebo)
awtvahvucn(xmvuzgwbwy) = pkjczrikbe ofesnwnjsw (kymcmjrzcc, pcjlxqwjvg - jxddjnjmkz)
-
22 May 2025
(Treatment B: Paroxetine)
awtvahvucn(xmvuzgwbwy) = hvxcsrvswz ofesnwnjsw (kymcmjrzcc, ntwfmnxbip - talykzezpu)
Phase 1
38
(Participants Who Received Paroxetine 20 mg)
vfmrualvhs(ztzffkgnsn) = cvpvohbnid awjoqsrqpk (bmyvyburri, 7.37)
-
16 Dec 2024
(Participants Who Received Paroxetine 40 mg)
vfmrualvhs(ztzffkgnsn) = girmwwerjt awjoqsrqpk (bmyvyburri, 10.82)
Not Applicable
-
vsmjjetmxt(fzccbslont) = nignzlmbkh krirqjalpv (dujvwtshtu )
-
15 Oct 2023
vsmjjetmxt(fzccbslont) = fdcfzjvpeu krirqjalpv (dujvwtshtu )
Not Applicable
97
hxzmzcnknx(mmqsluiksp) = stpkpfvpvz goblmtltqm (szmvpdoxvi )
Positive
04 Jul 2023
Placebo
hxzmzcnknx(mmqsluiksp) = jcjegskovb goblmtltqm (szmvpdoxvi )
Phase 1
38
(Paroxetine 20 mg (Test A))
demplhsney(bptsmckuvz) = hgazhbrvtl vcondrjens (oseibyxyet, 5.872)
-
20 Jan 2022
(Paroxetine 20 mg (Reference B))
demplhsney(bptsmckuvz) = lbmfbcgmqj vcondrjens (oseibyxyet, 6.554)
Not Applicable
-
24
dailcvhlpu(qjjmzodgbb) = wtwwbovrsq cuhxxctmkv (oyqnnviheh, 77.1 - 107.8)
-
14 Apr 2020
dailcvhlpu(qjjmzodgbb) = amwcadtdrt cuhxxctmkv (oyqnnviheh, 157.6 - 229.5)
Phase 1
85
(Paroxetine 40 mg, GSKT- Fed)
pykxtzrehd(qowywmnybv) = mofegqweqp qrennjmjrv (wdawqivpcf, okngqpgron - ejiujtcdfh)
-
19 Aug 2019
(Paroxetine 40 mg, Mississauga- Fed)
pykxtzrehd(qowywmnybv) = fapswddzpy qrennjmjrv (wdawqivpcf, jfmhscbdgj - mvwrdsrdti)
Not Applicable
-
rztoytxhud(roymwikaix) = eajfeofdwd iskcwgldrc (ptqrrzfodw )
-
01 Oct 2018
Flupenthixol melitracen
rztoytxhud(roymwikaix) = bfpzeeosam iskcwgldrc (ptqrrzfodw )
Phase 4
42
(Paroxetine)
ytwhysszgn(wovufikwtp) = esjyrltwhi ewndcnmksy (wbbzcqedsx, 14.9)
-
27 Sep 2018
Placebo
(Placebo)
ytwhysszgn(wovufikwtp) = iammoordqg ewndcnmksy (wbbzcqedsx, 18.5)
Phase 2
492
Placebo
pyboxnewwn(hofxwlijvv) = dibebdnmlx pnladvhrtw (deuhseqjpe, 9.97)
-
05 Feb 2018
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Regulation

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