A Randomized, Double-Masked, Vehicle-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Pimecrolimus 0.3% Ophthalmic Ointment (MR-139), in Subjects With Blepharitis

The objective of this study is to determine the efficacy and safety of Pimecrolimus 0.3% (MR-139) Ophthalmic Ointment.

Start Date22 Apr 2024

Sponsor / Collaborator

Famy Life Sciences Pvt Ltd.

CTRI/2024/03/063709 / RecruitingNot Applicable

A Randomized, Double Blind, Placebo Controlled, Three arm, Parallel, Multicentre, Study to Evaluate the Bioequivalence using Clinical Endpoint of Pimecrolimus Cream, 1% of Encube Ethicals Private Limited, India to Pimecrolimus Cream, 1% of Oceanside Pharmaceuticals, a division of Bausch Health US, LLC Bridgewater, NJ 08807 USA in Treatment of Mild to Moderate Atopic Dermatitis. - Nil

Start Date15 Mar 2024

Sponsor / Collaborator

Encube Ethicals Pvt Ltd.

NCT06241118 / RecruitingPhase 3

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 3-arm, Multinational, Multicenter Study to Evaluate the Efficacy and Safety of Amlitelimab by Subcutaneous Injection in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (AD) Who Are on Background Topical Corticosteroids and Have Had an Inadequate Response to Prior Biologic Therapy or Oral Janus Kinase (JAK) Inhibitor Treatment

This is a parallel group, Phase 3, multinational, multicenter, randomized, double-blind, placebo-controlled, 3-arm study for treatment of participants diagnosed with moderate-to-severe AD on background TCS who have had inadequate response to prior biologic or oral JAKi therapy.
The purpose of this study is to measure the efficacy and safety of treatment with amlitelimab solution for subcutaneous (SC) injection compared with placebo in participants with moderate-to-severe AD aged 12 years and older on background TCS and have had an inadequate response to prior biologic or an oral JAKi therapy.
Study details include:
At the end of the treatment period, participants will have the option to enter the Long-Term Safety Study LTS17367 (RIVER-AD).
The study duration will be up to 56 weeks for participants not entering the long-term safety study (LTS17367 [RIVER-AD]) including a 2 to 4-week screening, a 36-week randomized double-blind period, and a 16-week safety follow-up.
The study duration will be up to 40 weeks for participants entering the long-term safety study (LTS17367 [RIVER-AD]) including a 2 to 4-week screening and a 36-week randomized double-blind period.
The total treatment duration will be up to 36 weeks. The total number of visits will be up to 13 visits (or 12 visits for those entering the long-term safety study LTS17367 [RIVER-AD] study).

Start Date29 Feb 2024

Sponsor / Collaborator

Sanofi

100 Clinical Results associated with Pimecrolimus

100 Translational Medicine associated with Pimecrolimus

100 Patents (Medical) associated with Pimecrolimus

857

Literatures (Medical) associated with Pimecrolimus

01 Feb 2024·Journal of cosmetic dermatology

Clinical effectiveness of finasteride versus hydroxychloroquine in the treatment of frontal fibrosing alopecia: A randomized controlled trial

Article

Author: Saber, Mina ; Mohaghegh, Fatemeh ; Farokhshahi, Maryam ; Fatemi Naeini, Farahnaz ; Asilian, Ali

Abstract:

Background:

Frontal fibrosing alopecia (FFA) is a cicatricial alopecia with rapid epidemic growth. However, there is no agreement on the best therapeutic approach.

Aims:

To compare the therapeutic effects of finasteride as a first‐line systemic treatment of FFA versus hydroxychloroquine as a relatively safe and effective immunosuppressive drug.

Methods:

Thirty‐four female FFA patients were randomly assigned to receive either 400 mg/day of hydroxychloroquine or 2.5 mg/day of finasteride for 6 months. Topical treatments in both groups include pimecrolimus, mometasone, and minoxidil. Treatment efficacy was evaluated using the Frontal Fibrosing Alopecia Severity Score (FFASS), photography, and trichoscopy after 3 and 6 months.

Results:

Both the finasteride and hydroxychloroquine groups showed significant improvements in FFASS and trichoscopic scores (p < 0.01). However, there was no significant difference between the two groups during the study. Photographic assessment showed that more than 60% of patients in both groups had improved without statistically significant differences between the two groups.

Conclusions:

Both finasteride and hydroxychloroquine are equally effective, safe, and well‐tolerable for treating FFA patients.

31 Dec 2023·The Journal of dermatological treatment

Safety and efficacy of Pimecrolimus in atopic dermatitis among Chinese infants: a sub-group analysis of a five-year open-label study

Article

Author: Ni, Chunya ; Dou, Xia ; Sun, Xinfen ; Guo, Yifeng ; Liu, Lingling ; Sun, Qiuning ; He, Zhixin ; Wen, Weijing ; Yang, Qinping ; Zhao, Yi ; Li, Hongchun ; Zhu, Xuejun

INTRODUCTION:

Atopic dermatitis (AD) exhibits difference in immune polarization between Caucasians and Asian races due to which an evaluation of the efficacy and safety of Pimecrolimus (PIM) in Asian population is called for. The current study addresses the need via a sub-group analysis of the PETITE study (NCT00120523) to evaluate the safety and efficacy of PIM in Chinese infants.

MATERIALS AND METHODS:

Patients with AD (≥3 months-<12 months of age) were randomized in a 1:1 ratio to either PIM 1% cream or topical corticosteroids (TCS). The primary endpoint was safety. The secondary endpoint was efficacy.

RESULTS:

120 patients were randomized to either PIM 1% or TCS (n = 61 for PIM, n = 59 for TCS). The most often reported adverse events were reported by similar proportions of patients treated with PIM or TCS. There was a progressive increase in overall IGA treatment success in infants treated with PIM (82.9%, p < .05, 95% CI: 70.4, 95.3) after 26 weeks which was comparable to the TCS group (88.5%, p < .05, 95% CI: 79.8, 97.1).

CONCLUSION:

PIM showed an early and sustained efficacy in the Chinese sub-population with a substantial corticosteroid-sparing effect in patients with AD.

27 Dec 2023·Cureus

Morphea Involving the Lips and Gingiva: A Rare Case Report

Author: Alburaykan, Yara B ; Alyahya, Areen A ; Alqasem, Afyaa A ; Aldosari, Bader ; Alshagroud, Rana S ; Aladnan, Abdullah M ; Albagieh, Hamad ; Almashham, Lama Y ; Aboheimed, Nada I

Morphea is a subtype of scleroderma that does not involve Raynaud's phenomenon or internal organ involvement. It is a connective tissue disease that features the excessive deposition of collagen in the dermis and subcutaneous tissue, leading to a thickening of the dermis and subcutaneous tissue, eventually forming a scar-like lesion. We represent a 19-year-old male Saudi patient displaying a white patch on the marginal gingiva of tooth #21 and multiple yellowish papules on the outer surface of the lip. Both teeth #21 and #22 have experienced recession and bone loss. The patient's clinical history and histopathology revealed characteristic features of localized scleroderma. A treatment was proposed involving immunosuppressants, methotrexate, and pimecrolimus cream along with topical corticosteroids and excimer laser therapy (308 nm). The patient followed the treatment plan for a full month and the white patch quickly improved for the patient. Afterward, the patient has been taking only methotrexate with a significant but gradual improvement. In this paper, we discuss the differential diagnosis to be considered and present an unusual occurrence of localized scleroderma in the oral cavity.

News (Medical) associated with Pimecrolimus

12 Jan 2023

·www.prnewswire.com

AMERICAN ACADEMY OF DERMATOLOGY ISSUES UPDATED GUIDELINES FOR THE MANAGEMENT OF ATOPIC DERMATITIS IN ADULTS WITH TOPICAL THERAPIES

Both well-established and newer topical treatments addressed ROSEMONT, Ill., Jan. 12, 2023 /PRNewswire/ -- Often called eczema or atopic eczema, atopic dermatitis is a common skin condition, affecting 1 in 10 Americans1. Although atopic dermatitis occurs most frequently in children, it also affects adults and can have a significant impact on patients' quality of life. To help ensure that adult patients with atopic dermatitis receive the best possible treatment, the American Academy of Dermatology (AAD) has published updated guidelines of care for the management of atopic dermatitis in adults with topical therapies in the Journal of the American Academy of Dermatology. Continue Reading This is the second in a series of updated guidelines the AAD is producing on the condition. The updates, which outline best practices for topical treatment of the disease, were developed by an expert workgroup of 12 physicians, including 11 dermatologists, an allergist/pediatrician and one patient representative. The AAD published updated guidelines of care for the management of atopic dermatitis in adults with topical therapies Tweet this "Atopic dermatitis is the most common type of eczema, and it can interfere with a person's daily life without proper treatment," said board-certified dermatologist Robert Sidbury, MD, MPH, FAAD, co-chair of the AAD's Atopic Dermatitis Guideline Workgroup. "The guidelines provide evidence-based recommendations for dermatologists to use in caring for their adult atopic dermatitis patients with topical treatments, which have come a long way since the guidelines were last revised in 2014. This update reflects the latest advances in topical medications that are now available to help adults with atopic dermatitis." Atopic dermatitis can develop on any area of your skin at any age. Adults who have atopic dermatitis often have red to dark patches and scaly skin. They also can have extremely dry skin, hand eczema, eye problems, and skin that is easily irritated. "While atopic dermatitis cannot be cured, it can be controlled with proper treatment," said Dr. Sidbury. "A plan created by a board-certified dermatologist can help ease symptoms, reduce flare-ups, and prevent it from worsening. Topical treatments remain one of the most popular options due to their effective track record and overall safety." The Atopic Dermatitis Workgroup developed 12 recommendations on how to manage atopic dermatitis in adults with topical therapies. The workgroup provided new recommendations for non-prescription methods as well as prescription treatments. Strong recommendations were made for topical treatments in which the benefits clearly outweigh the risks and burdens to the patient. These recommendations apply to most patients in most circumstances. Strong recommendations were made for the use of the following: Moisturizers help to relieve patients' dry, cracked skin, decrease inflammation, and reduce the severity of and increase the time between flare-ups. Topical calcineurin inhibitors (pimecrolimus 1% cream and tacrolimus 0.03% or 0.1% ointment) reduce patients' inflammation and itching, as well as decrease their flare-ups. Topical corticosteroids are commonly used as the first-line treatment for patients with atopic dermatitis in all skin regions. They help to relieve itching, decrease inflammation, and can decrease infections. Phosphodiesterase-4 inhibitor (crisaborole ointment) can reduce patients' inflammation, help relieve itching, and decrease infections. Janus kinase inhibitor (ruxolitinib cream) can be used short term to ease the inflammation and itching of patients with mild to moderate atopic dermatitis. The guidelines provide conditional recommendations for the use of bathing and wet wrap therapy. Conditional recommendations apply to most patients, but the most appropriate action may differ depending on individual patient factors. Bathing, followed by moisturization , helps patients hydrate the skin. Bleach baths can help patients prevent infection and get rid of bacteria on their skin. Wet wrap therapy utilizes wet bandages to help hydrate and soothe patients' skin. This treatment provides a barrier against scratching, helps to decrease redness and inflammation, and can reduce the bacteria on patients' skin. "These recommendations are based on the latest evidence-based research on the most effective topical treatments for our patients," said Dawn Davis, MD, FAAD, co-chair of the AAD's Atopic Dermatitis Guideline Workgroup. "These recommended treatments can be used individually or in combination with other treatments." The guidelines made conditional recommendations against the use of topical antimicrobials, antiseptics, and antihistamines due to the low certainty of evidence, which means the true effect may be substantially different from the estimated effect. "These guidelines were updated to enable dermatologists to optimize topical treatments to provide adult atopic dermatitis patients with expert care," said board-certified dermatologist Mark D. Kaufmann MD, FAAD, president of the AAD. "Since each patient's atopic dermatitis is unique, board-certified dermatologists can determine the treatments that will work best for them. I'm very grateful to our workgroup for providing these important updates to help patients worldwide." To find a board-certified dermatologist in your area, visit aad.org/findaderm. More information: Eczema Types: Atopic Dermatitis Overview Eczema Types: Atopic Dermatitis Symptoms Guidelines of care for the management of atopic dermatitis in adults with topical therapies About the AAD 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 20,000 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, Pinterest and YouTube and @AADskin1 on Instagram. About JAAD The Journal of the American Academy of Dermatology is the most widely read dermatology journal in the world, according to Kantar Media. JAAD was the first most-cited dermatology journal in 2021, according to impact factor rankings from Clarivate's Journal Citation Reports (JCR) Web of Science Group. JAAD also has two open-access companion titles: JAAD Case Reports and JAAD International. Follow @JAADJournals on Facebook, Twitter, and Instagram. SOURCE American Academy of Dermatology

12 Jan 2023

·www.biospace.com

American Academy of Dermatology Issues Updated Guidelines for the Management of Atopic Dermatitis in Adults With Topical Therapies

Both well-established and newer topical treatments addressed ROSEMONT, Ill., Jan. 12, 2023 /PRNewswire/ -- Often called eczema or atopic eczema, atopic dermatitis is a common skin condition, affecting 1 in 10 Americans1. Although atopic dermatitis occurs most frequently in children, it also affects adults and can have a significant impact on patients' quality of life. To help ensure that adult patients with atopic dermatitis receive the best possible treatment, the American Academy of Dermatology (AAD) has published updated guidelines of care for the management of atopic dermatitis in adults with topical therapies in the Journal of the American Academy of Dermatology. The AAD published updated guidelines of care for the management of atopic dermatitis in adults with topical therapies This is the second in a series of updated guidelines the AAD is producing on the condition. The updates, which outline best practices for topical treatment of the disease, were developed by an expert workgroup of 12 physicians, including 11 dermatologists, an allergist/pediatrician and one patient representative. "Atopic dermatitis is the most common type of eczema, and it can interfere with a person's daily life without proper treatment," said board-certified dermatologist Robert Sidbury, MD, MPH, FAAD, co-chair of the AAD's Atopic Dermatitis Guideline Workgroup. "The guidelines provide evidence-based recommendations for dermatologists to use in caring for their adult atopic dermatitis patients with topical treatments, which have come a long way since the guidelines were last revised in 2014. This update reflects the latest advances in topical medications that are now available to help adults with atopic dermatitis." Atopic dermatitis can develop on any area of your skin at any age. Adults who have atopic dermatitis often have red to dark patches and scaly skin. They also can have extremely dry skin, hand eczema, eye problems, and skin that is easily irritated. "While atopic dermatitis cannot be cured, it can be controlled with proper treatment," said Dr. Sidbury. "A plan created by a board-certified dermatologist can help ease symptoms, reduce flare-ups, and prevent it from worsening. Topical treatments remain one of the most popular options due to their effective track record and overall safety." The Atopic Dermatitis Workgroup developed 12 recommendations on how to manage atopic dermatitis in adults with topical therapies. The workgroup provided new recommendations for non-prescription methods as well as prescription treatments. Strong recommendations were made for topical treatments in which the benefits clearly outweigh the risks and burdens to the patient. These recommendations apply to most patients in most circumstances. Strong recommendations were made for the use of the following: Moisturizers help to relieve patients' dry, cracked skin, decrease inflammation, and reduce the severity of and increase the time between flare-ups. Topical calcineurin inhibitors (pimecrolimus 1% cream and tacrolimus 0.03% or 0.1% ointment) reduce patients' inflammation and itching, as well as decrease their flare-ups. Topical corticosteroids are commonly used as the first-line treatment for patients with atopic dermatitis in all skin regions. They help to relieve itching, decrease inflammation, and can decrease infections. Phosphodiesterase-4 inhibitor (crisaborole ointment) can reduce patients' inflammation, help relieve itching, and decrease infections. Janus kinase inhibitor (ruxolitinib cream) can be used short term to ease the inflammation and itching of patients with mild to moderate atopic dermatitis. The guidelines provide conditional recommendations for the use of bathing and wet wrap therapy. Conditional recommendations apply to most patients, but the most appropriate action may differ depending on individual patient factors. Bathing, followed by moisturization, helps patients hydrate the skin. Bleach baths can help patients prevent infection and get rid of bacteria on their skin. Wet wrap therapy utilizes wet bandages to help hydrate and soothe patients' skin. This treatment provides a barrier against scratching, helps to decrease redness and inflammation, and can reduce the bacteria on patients' skin. "These recommendations are based on the latest evidence-based research on the most effective topical treatments for our patients," said Dawn Davis, MD, FAAD, co-chair of the AAD's Atopic Dermatitis Guideline Workgroup. "These recommended treatments can be used individually or in combination with other treatments." The guidelines made conditional recommendations against the use of topical antimicrobials, antiseptics, and antihistamines due to the low certainty of evidence, which means the true effect may be substantially different from the estimated effect. "These guidelines were updated to enable dermatologists to optimize topical treatments to provide adult atopic dermatitis patients with expert care," said board-certified dermatologist Mark D. Kaufmann MD, FAAD, president of the AAD. "Since each patient's atopic dermatitis is unique, board-certified dermatologists can determine the treatments that will work best for them. I'm very grateful to our workgroup for providing these important updates to help patients worldwide." To find a board-certified dermatologist in your area, visit aad.org/findaderm. More information: Eczema Types: Atopic Dermatitis Overview Eczema Types: Atopic Dermatitis Symptoms Guidelines of care for the management of atopic dermatitis in adults with topical therapies About the AAD 1938, is the largest, most influential and most representative of all dermatologic associations. With a membership of more than 20,000 physicians worldwide, the AAD is committed to advancing the diagnosis and medical, surgical and cosmetic treatment of the skin, hair and nails; advocating high standards in clinical practice, education and research in dermatology; and supporting and enhancing patient care because skin, hair, and nail conditions can have a serious impact on your health and well-being. For more information, contact the AAD at (888) 462-DERM (3376) or aad.org. Follow @AADskin on Facebook, Pinterest and YouTube and @AADskin1 on Instagram. About JAAD The Journal of the American Academy of Dermatology is the most widely read dermatology journal in the world, according to Kantar Media. JAAD was the first most-cited dermatology journal in 2021, according to impact factor rankings from Clarivate's Journal Citation Reports (JCR) Web of Science Group. JAAD also has two open-access companion titles: JAAD Case Reports and JAAD International. Follow @JAADJournals on Facebook, Twitter, and Instagram. View original content: SOURCE American Academy of Dermatology

08 Nov 2022

·medcitynews.com

Viatris Sees Vision Drugs as Key to Growth and Commits $750M to Two M&A Deals

Viatris, which is in the midst of a strategy shift intended to return the company to revenue growth, is acquiring two companies that together bring one commercialized product and five programs ready for pivotal testing or already in Phase 3 development. The new assets coming to Viatris are in ophthalmology, one of the new areas of focus for the company. In total, Viatris said it expects to spend between $700 million and $750 million to acquire publicly traded Oyster Point Pharma and privately held Famy Life Sciences. The acquisitions announced Monday come less than two years after the close of the merger that formed Viatris, bringing together the generic drugs giant Mylan with Upjohn, the generic medications and off-patent drugs unit of Pfizer. In its new incarnation, Viatris aimed to offer a portfolio of drugs projected to top $3 billion in global revenue. The Canonsburg, Pennsylvania-based company would soon change course. In February, Viatris announced it had agreed to sell its biosimilars business to Biocon Biologics for $3.3 billion. That deal resulted from a strategic review conducted to streamline the business and better position it for growth. “Non-core” assets like biosimilars would be sold. The remaining Viatris business would focus on three therapeutic areas: ophthalmology, gastrointestinal, and dermatology. At the time that deal was announced, Viatris also disclosed it had acquired rights to Pimecrolimus, an eye ointment to treat blepharitis, a type of eye irritation. The company’s latest deals further expand its eye drug ambitions. Oyster Point’s main asset is Tyrvaya, a dry eye disease drug approved last year that the biotech company developed in a nasal spray formulation. The drug works by binding to certain receptors, activating them to stimulate cells and glands involved in producing the tear film covering the eye. For the first half of this year, the Princeton, New Jersey-based company reported the drug accounted for $7.3 million in revenue. Oyster Point’s pipeline includes two preclinical gene therapies in development for certain eye surface diseases. According to the financial terms of deal, Viatris will pay $11 cash for each share of Oyster Point. That price is a 31.7% premium to the stock’s closing price last Friday. The agreement also includes a contingent value right, an additional $2 per share payment that’s tied to Oyster Point achieving certain goals. Viatris is paying about $300 million to acquire Famy Life Sciences, according to the Economic Times, a business newspaper in India, where Famy is based. The Times reported that the Taparia family, which owned the company, will keep retain the non-ophthalmic business. There’s history behind the transaction. In 2015, Mylan paid $750 million up front to acquire Famy Care, a women’s healthcare company started by the Taparias. Family members started Famy Life Sciences in 2017. According to a Viatris investor presentation, Famy’s five clinical-stage ophthalmic programs include Phase 3-ready assets for dry eye disease, blepharitis, and presbyopia. A drug candidate for dim light or night vision disturbances is already in Phase 3 testing; a Phase 3 test in rehydration of mydriasis is complete. The products and product candidates coming to the company in the acquisitions are projected to generate more than $1 billion in revenue by 2028, Viatris said in the presentation. “These acquisitions bring us an innovative growth asset, Tyrvaya, and five additional Phase 3 or Phase 3-ready programs that give us a significant head-start in creating a leading ophthalmology franchise,” Viatris CEO Michael Goettler said in a prepared statement. The Oyster Point acquisition is expected to close in the first quarter of 2023. When it does, Oyster Point CEO Jeff Nau will lead the new Viatris ophthalmology business, which will operate as a separate division within the larger company.

Generic DrugBiosimilarAcquisition

100 Deals associated with Pimecrolimus

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KEGG	Wiki	ATC	Drug Bank
D05480	Pimecrolimus	D11AH02	DB00337

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Eczema	CN	Novartis Pharma AG	29 Sep 2005
Dermatitis, Atopic	US	Bausch Health US LLC	13 Dec 2001

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Dermatitis, Perioral	Phase 3	DE	Novartis AG	01 Sep 2005
Chronic dermatitis	Phase 3	-	Novartis AG	01 Jul 2004
Lichen Sclerosus Et Atrophicus	Phase 2	US	Novartis AG	01 Oct 2006
Vulvar Lichen Sclerosus	Phase 2	US	Novartis AG	01 Oct 2006
Kerato conjunctivitis sicca	Phase 2	US	Novartis AG	01 Sep 2004
Vitiligo	Phase 2	BE	Novartis AG	01 May 2004

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


WCD2023	Not Applicable	Dermatitis, Atopic	-	Pimecrolimus	mvekpqnnsq(kbilrregiw) = for at least three months efghhicqhv (ungwbtaprc )	Positive	03 Jul 2023
NCT00120523 (PETITE study, EADV2022)	Phase 3	Dermatitis, Atopic	120	Pimecrolimus 1% cream	wqnrwgrswc(lgdnthcynk) = The most frequently reported AEs (≥ 30% in any treatment group) are listed in Table-1. These AEs were reported by similar proportions of patients treated with PIM or TCS. dmxwgfixus (thdlsxdhqv )	-	07 Sep 2022
				Topical corticosteroids (TCS)
NCT00403559 (CTgov)	Phase 2	Dermatitis, Seborrheic	113	Elidel (Elidel Cream (Pimecrolimus))	royupulehj(hmhmygbmqa) = jywrthpcnt fqehkvibfx (votgitexaa, gcvperwzfr - lpptcqwqpw)	-	14 Mar 2022
				Ketoconazole Cream (Ketoconazole Cream (Nizoral))	royupulehj(hmhmygbmqa) = ixgymzekrc fqehkvibfx (votgitexaa, vowijbindu - ucweiogfpt)
NCT02791308 (CTgov)	Phase 3	Dermatitis, Atopic	587	Pimecrolimus Cream, 1% (Pimecrolimus Cream, 1%)	qvzlqnxxyf(ntvtsjmajc) = crlqoewiet ddsdxacloo (keqskmqtju, duirzhfswk - kbcnjdmbvl) View more	-	24 Apr 2020
				Pimecrolimus Cream 1% (Valeant) (Elidel Cream, 1%)	qvzlqnxxyf(ntvtsjmajc) = utsmzdjoew ddsdxacloo (keqskmqtju, cosveivyre - jmatnaoscv) View more
NCT03107611 (CTgov)	Phase 3	Dermatitis, Atopic	654	Pimecrolimus Cream, 1% (Test)	jkzzogensk(kgpaprollx) = kbcuyckluj voydlivzfh (hkhkbefdtd, sfxvnrwghh - ncwtiuafvc) View more	-	17 Mar 2020
				Pimecrolimus Cream, 1% (Reference Standard)	jkzzogensk(kgpaprollx) = rwxlasjvqb voydlivzfh (hkhkbefdtd, sjzjcxawsh - etaauhcpep) View more
NCT01692626 (CTgov)	Phase 2	Exanthema	13	sidePimecrolimus (Left sidePimecrolimus Cream)	megxhysauo(wrspjncmuo) = npwtjczpdg nytfvhfzbj (vcejueobyc, nonrxpxmmc - fgzjogaxwi)	-	15 Mar 2017
				Pimecrolimus Cream (The Right Side the Pimecrolimus Cream)	megxhysauo(wrspjncmuo) = bcumfpedqy nytfvhfzbj (vcejueobyc, xuhlvrubdf - dajwxzghqi)
NCT00120523 (Pubmed \| Pediatrics) Manual	Phase 3	Dermatitis, Atopic First line	2,418	pimecrolimus	ybxrromjce(dzuryxgycc) = wvjqgoybml lbbixcisuk (fkptzfkidl ) View more	Similar	01 Apr 2015
				topical corticosteroids	ybxrromjce(dzuryxgycc) = fxbromvfrc lbbixcisuk (fkptzfkidl ) View more
NCT00208026 (CTgov)	Phase 1/2	Netherton Syndrome	3	Pimecrolimus Cream (Patient 1)	xkwfifpvwq(fvupevoyhs) = qcocygqqgz euojetikku (argzhgzbkl, jczrtkaiwe - mscwqnmxri) View more	-	12 Dec 2014
				Pimecrolimus Cream (Patient 2)	xkwfifpvwq(fvupevoyhs) = texrzctpdl euojetikku (argzhgzbkl, evtlpnjaqu - rmxchmkgcm) View more
NCT00946478 (CTgov)	Not Applicable	Eczema \| Dermatitis, Atopic	40	Pimecrolimus (Pimecrolimus)	qtpgoonkur(yqkyzwctdt) = cjguxqmbnz qqrhjqjcws (lxlfjxtzxv, iwzsdwvlyr - gtbzeuploy) View more	-	10 Mar 2014
				Vehicle cream (Vehicle Cream)	qtpgoonkur(yqkyzwctdt) = btllmmlhha qqrhjqjcws (lxlfjxtzxv, imalrgpsbu - uxddgmvocd) View more
NCT00120523 (PETITE study, CTgov)	Phase 3	Dermatitis, Atopic	2,418	Pimecrolimus (Pimecrolimus)	dewhnprmbv(ntfisaipgh) = liqcjgfhuq nykofezfzc (kpdrzuhcga, onjzfistpw - mitupkphfh) View more	-	16 Jan 2013
				Corticosteroids (Topical Corticosteroids)	dewhnprmbv(ntfisaipgh) = keienturys nykofezfzc (kpdrzuhcga, zdypwuccfw - mbebdkzprp) View more

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