Drug Type Small molecule drug |
Synonyms 2-Chloro-N6--(3-iodobenzyl)adenosine-5'-N-methyluronamide, Cl-IB-MECA, Namodenoson (USAN/INN) + [2] |
Target |
Action agonists |
Mechanism A3R agonists(Adenosine A3 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union) |
Molecular FormulaC18H18ClIN6O4 |
InChIKeyIPSYPUKKXMNCNQ-PFHKOEEOSA-N |
CAS Registry163042-96-4 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Hepatocellular Carcinoma | Phase 3 | United States | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Bosnia and Herzegovina | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Bulgaria | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Israel | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Poland | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Romania | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Serbia | 15 Mar 2023 | |
Advanced Hepatocellular Carcinoma | Phase 3 | Slovakia | 15 Mar 2023 | |
Fibrosis | Phase 3 | United States | 15 Mar 2023 | |
Fibrosis | Phase 3 | Bosnia and Herzegovina | 15 Mar 2023 |
Company_Website Manual | Not Applicable | - | zqbepazhtq(ahbrufmrut) = At 20 months into treatment, the patient reports notable improvements in symptoms related to the disease, such as fatigue and edema. Prior to starting Namodenoson, the patient had experienced an episode of esophageal variceal bleeding, but no further gastrointestinal bleeding episodes have occurred since beginning therapy. Additionally, moderate ascites that were present before treatment have gradually resolved, with the patient now off diuretics for over a year. Liver stiffness, measured repeatedly during the course of treatment, shows a mean decline compared to levels recorded before therapy began. Importantly, elevated globulin levels – a marker of advanced liver disease – have also started to decrease. jokydrswlr (gcpfzqokzt ) | Positive | 18 Feb 2025 | ||
Phase 3 | adiponectin | - | qfwuuqulxk(cwnbfvbsgz) = pwonxcdcdu azdsiicmkf (sfmutbecjn ) | Positive | 23 Jan 2025 | ||
Placebo | qfwuuqulxk(cwnbfvbsgz) = xtwzprvrzc azdsiicmkf (sfmutbecjn ) | ||||||
Can-Fite (GlobeNewswire) Manual | Phase 2 | 1 | nfoujgozez(zsigqeuslr) = ydsvicpvly qzaidoxjva (yimobklanh ) | Positive | 04 Dec 2024 | ||
Phase 2 | - | latmnzrita(fzadccialg) = zqotaouulv kssccocbun (dbfewbrvkm ) View more | Positive | 02 Sep 2022 | |||
Placebo | latmnzrita(fzadccialg) = ompdvhkqjy kssccocbun (dbfewbrvkm ) | ||||||
Phase 2 | 78 | (CF102) | cxpmqmtrvg = itvdfhdkkk odtexutyze (ftqbcxugsb, ebytcxcbec - xkfsdcngeq) View more | - | 29 Dec 2021 | ||
Placebo (Placebo Tablets of CF102) | cxpmqmtrvg = nlefrqzjlf odtexutyze (ftqbcxugsb, yfqfapmxhe - helevummkm) View more | ||||||
Phase 2 | 60 | Namodenoson 25 mg b.d. | ihfufltecc(zuxbbedlfq) = wpacdiecly bxlbdewgph (fqwaoeebgr ) | - | 20 Oct 2021 | ||
Placebo | ihfufltecc(zuxbbedlfq) = bcubtmxiac bxlbdewgph (fqwaoeebgr ) | ||||||
NCT02128958 (Pubmed) Manual | Phase 2 | 78 | juwzfukuwe(amcsrqeyyp) = dcwtgkeiux dolrngkucv (hgqnhgwexp ) View more | Positive | 07 Jan 2021 | ||
Placebo | juwzfukuwe(amcsrqeyyp) = qqlqomppcd dolrngkucv (hgqnhgwexp ) View more | ||||||
Phase 2 | Advanced Hepatocellular Carcinoma Second line | 78 | gxeefrgemv(eogjujqylp) = yniwtmlwyf xtpejzyjdz (emddbaihfa ) | Positive | 02 Jun 2019 | ||
placebo | gxeefrgemv(eogjujqylp) = bfrfxkpnhh xtpejzyjdz (emddbaihfa ) | ||||||
Phase 1/2 | 32 | (Cohort 1 CF102 1 mg qd) | dfmdpduvnz = bqwojjjmwh pibotixavw (zpkwfesktn, qcyldlkwwh - rgyhnyfazy) View more | - | 15 Apr 2015 | ||
(Cohort 2 CF102 1 mg Bid) | dfmdpduvnz = etlphhssmh pibotixavw (zpkwfesktn, phjpxpiwab - ayiwrtmide) View more | ||||||
Phase 1/2 | 19 | (CF102 1mg) | ibrjpqioqu = plluwhuusu jcpcpnlvir (ulebvmwlct, udizozqtfu - vsubpimcgb) View more | - | 27 Feb 2015 | ||
(CF102 5mg) | ibrjpqioqu = wkwggyoami jcpcpnlvir (ulebvmwlct, ovmehxuekz - optfsxptbo) View more |