Last update 14 Mar 2026

M-4112

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
M 4112, M4112, MS201408-0005
Target
IDO1 x TDO
Action
inhibitors
Mechanism
IDO1 inhibitors(Indoleamine 2,3-dioxygenase inhibitors), TDO inhibitors(Tryptophan 2,3-dioxygenase inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Metastatic Solid Tumor
Originator Organization
Merck Serono SA
Active Organization-
Inactive Organization
EMD Serono Research & Development Institute, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with M-4112
NCT03306420
/ TerminatedPhase 1
Phase I, First-in-Human, Open-Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Activity of MS201408-0005A as Single Agent and Sequentially in Combinations With MS201408-0005C or MS201408-0005B in Subjects With Metastatic or Locally Advanced Unresectable Solid Tumors
100 Clinical Results associated with M-4112
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100 Translational Medicine associated with M-4112
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100 Patents (Medical) associated with M-4112
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100 Deals associated with M-4112
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Solid TumorPhase 1
United States
EMD Serono Research & Development Institute, Inc.
03 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03306420 (CTgov)
Phase 1
Metastatic Solid Tumor
15
(Part 1A Dose Escalation: M4112 100 mg)
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-
06 Feb 2020
(Part 1A Dose Escalation: M4112 200 mg)
tdsfvwglta = umeffxpjej rxzzstvstt (cbkjwnvpuz, rzqbrchifn - uljzqlespc)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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