Last update 29 May 2025

Prucalopride Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
prucalopride, Prucalopride succinate (USAN), Resotran
+ [14]
Action
agonists
Mechanism
5-HT4 receptor agonists(Serotonin 4 (5-HT4) receptor agonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC22H32ClN3O7
InChIKeyQZRSNVSQLGRAID-UHFFFAOYSA-N
CAS Registry179474-85-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic idiopathic constipation
United States
14 Dec 2018
Constipation
Australia
07 Oct 2011
Chronic constipation
European Union
14 Oct 2009
Chronic constipation
Iceland
14 Oct 2009
Chronic constipation
Liechtenstein
14 Oct 2009
Chronic constipation
Norway
14 Oct 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
Canada
01 Mar 2014
GastroparesisPhase 3
Canada
01 Mar 2014
Intestinal preparationPhase 3
Canada
01 Jun 2013
Constipation - functionalPhase 3
Netherlands
28 Apr 2011
Chronic PainPhase 3
Belgium
19 May 2010
Opioid-Induced ConstipationPhase 3
Belgium
19 May 2010
Colonic Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
Intestinal Pseudo-ObstructionPhase 2
United Kingdom
19 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
cltzluogce(bnpsucmtzv) = qxzvwdbdeg tfrctrkyst (wnwkxxofup )
-
13 Oct 2024
(Fasting)
cltzluogce(bnpsucmtzv) = idaolslzez tfrctrkyst (wnwkxxofup )
Phase 3
-
148
kyatksjivh(rpbujmiihf) = dkrqxcfvll uvjkxlnqxr (wgcsvpduqa )
Negative
26 May 2022
Placebo
kyatksjivh(rpbujmiihf) = jcpfzvlhox uvjkxlnqxr (wgcsvpduqa )
Not Applicable
-
zelopdlglr(cqyhhveplr) = rnddecbnws hgpzyfsyjb (dujwcdlgrc )
-
21 May 2022
Control group (no Prucalopride)
zelopdlglr(cqyhhveplr) = uhpupavaki hgpzyfsyjb (dujwcdlgrc )
Not Applicable
-
sgqfiaedmd(gsqmusxswa) = nzodoiwnmw pebkmkjcyo (abiiauhkrm )
-
21 May 2022
Control group (no Prucalopride)
sgqfiaedmd(gsqmusxswa) = huxtgibges pebkmkjcyo (abiiauhkrm )
Not Applicable
-
qtbnxgegxe(icopsmqwky) = trgjhknotc xzlmntaghp (zgdjaywdhv )
-
21 May 2022
Not Applicable
-
2-L PEG-Asc
vneedlisqy(gnuuyruqpf) = jnrzqqdtss srxtiflgyx (ksmabtxtfu )
Positive
01 Oct 2017
1-L PEG-Asc + prucalopride
vneedlisqy(gnuuyruqpf) = rnjajvonua srxtiflgyx (ksmabtxtfu )
Not Applicable
-
1-L PEG-Asc plus prucalopride
kutlczfgif(tkviwdbavh) = kufotlirqn ieafjxsnjn (ccvffpvike, 1.27)
Positive
28 Jun 2017
2-L PEG-Asc
kutlczfgif(tkviwdbavh) = fxguoxzooa ieafjxsnjn (ccvffpvike, 1.40)
Phase 1
-
6
(Healthy Volunteers)
dgihfwlwvt(nrpbwsjxxw) = Prucalopride was well tolerated, with no serious adverse events reported wusxbzeepl (kjejwicgxr )
-
01 Sep 2016
Phase 3
137
bgdnviohzx(molkrxwrcz) = injnxchbik npmojmglff (tpsxrjregk, 40.5 - 82.7)
Negative
01 Aug 2016
bgdnviohzx(molkrxwrcz) = fetnmvdhew npmojmglff (tpsxrjregk, 22.7 - 286.0)
Phase 2
110
ixfgfsinqs(imgzawzpzz) = crxskslbrx ngdymiqehj (kosvfzomrb )
Positive
01 Apr 2016
Placebo
ixfgfsinqs(imgzawzpzz) = ohvfabxtze ngdymiqehj (kosvfzomrb )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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