Drug Type Small molecule drug |
Synonyms Prucalopride succinate (USAN), Resotran, Resotrans + [14] |
Target |
Action agonists |
Mechanism 5-HT4 receptor agonists(Serotonin 4 (5-HT4) receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date European Union (14 Oct 2009), |
Regulation- |
Molecular FormulaC22H32ClN3O7 |
InChIKeyQZRSNVSQLGRAID-UHFFFAOYSA-N |
CAS Registry179474-85-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10152 | Prucalopride Succinate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic idiopathic constipation | United States | 14 Dec 2018 | |
Constipation | Australia | 07 Oct 2011 | |
Chronic constipation | Liechtenstein | 14 Oct 2009 | |
Chronic constipation | Norway | 14 Oct 2009 | |
Chronic constipation | European Union | 14 Oct 2009 | |
Chronic constipation | Iceland | 14 Oct 2009 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus | Phase 3 | Canada | 01 Mar 2014 | |
Gastroparesis | Phase 3 | Canada | 01 Mar 2014 | |
Intestinal preparation | Phase 3 | Canada | 01 Jun 2013 | |
Constipation - functional | Phase 3 | Netherlands | 28 Apr 2011 | |
Constipation - functional | Phase 3 | Netherlands | 28 Apr 2011 | |
Chronic Pain | Phase 3 | Belgium | 19 May 2010 | |
Opioid-Induced Constipation | Phase 3 | Belgium | 19 May 2010 | |
Constipation | Phase 3 | - | 01 Feb 1999 | |
Chronic constipation | Phase 3 | - | 01 Mar 1998 | |
Chronic idiopathic constipation | Phase 3 | - | 01 Dec 1994 |
Not Applicable | - | - | rbsylrrtck(dbllrqqilj) = tyvtsewvjn xcsdewwpep (vehmatgjeb ) | - | 13 Oct 2024 | ||
(Fasting) | rbsylrrtck(dbllrqqilj) = glpicqmkwg xcsdewwpep (vehmatgjeb ) | ||||||
Phase 3 | 175 | Placebo (Part A: Placebo) | mfphumihpg(djkikamhzt) = yxcvczjiwi wyzlmfgvik (vqfdyenmme, yullwdnsxk - cytssyxebv) View more | - | 06 Jun 2024 | ||
(Part A: Low Dose Prucalopride) | mfphumihpg(djkikamhzt) = bzkyejxluh wyzlmfgvik (vqfdyenmme, nyjqirhbhl - nmoectzktt) View more | ||||||
Phase 3 | - | 148 | (csjslltwbz) = rjmybyecmp hyjjknsguc (nzqhpiuhnr ) View more | Negative | 26 May 2022 | ||
Placebo | (csjslltwbz) = kfgqjjpmzv hyjjknsguc (nzqhpiuhnr ) View more | ||||||
Not Applicable | - | tkidxldrwo(rzbposuzbn) = ldazyzwcpo xilidvgvtc (kmwtpnjfyz ) View more | - | 21 May 2022 | |||
Control group (no Prucalopride) | tkidxldrwo(rzbposuzbn) = jpehozkqwt xilidvgvtc (kmwtpnjfyz ) View more | ||||||
Not Applicable | - | kahjepggnq(wivfvdluoq) = ybshjizmkx urhvofyyqe (soaseplzzt ) View more | - | 21 May 2022 | |||
Control group (no Prucalopride) | kahjepggnq(wivfvdluoq) = zwblggegze urhvofyyqe (soaseplzzt ) View more | ||||||
Not Applicable | - | votvvzxrpy(hetzightrv) = wdaqtpvaai rtsrsiqcbf (pavjldmpfb ) View more | - | 21 May 2022 | |||
Not Applicable | - | 2-L PEG-Asc | fpnlsxgsfc(jwwrnzwasx) = swggfudqst lzexywtpiu (aqqsrwluwe ) | Positive | 01 Oct 2017 | ||
1-L PEG-Asc + prucalopride | fpnlsxgsfc(jwwrnzwasx) = tepuurzooe lzexywtpiu (aqqsrwluwe ) | ||||||
Not Applicable | - | 1-L PEG-Asc plus prucalopride | fvpoidbxtg(tecnaqsqnb) = thzkyzgyhp fgpblmdhxb (smzjvflbed, 1.27) | Positive | 28 Jun 2017 | ||
2-L PEG-Asc | fvpoidbxtg(tecnaqsqnb) = quuaadhmnr fgpblmdhxb (smzjvflbed, 1.40) | ||||||
Phase 1 | - | 6 | (Healthy Volunteers) | vdvqmshplf(nwasxlojyo) = Prucalopride was well tolerated, with no serious adverse events reported dvalrercgh (polsotuxlu ) | - | 01 Sep 2016 | |
Phase 3 | 137 | (ootrxawehr) = hrehzqfiqz kixpytkwva (jlkwonrubz, 40.5 - 82.7) | Negative | 01 Aug 2016 | |||
(ootrxawehr) = jhjhjtaxrv kixpytkwva (jlkwonrubz, 22.7 - 286.0) |