Last update 20 Mar 2025

Prucalopride Succinate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Prucalopride succinate (USAN), Resotran, Resotrans
+ [14]
Action
agonists
Mechanism
5-HT4 receptor agonists(Serotonin 4 (5-HT4) receptor agonists)
Therapeutic Areas
Drug Highest PhaseApproved
First Approval Date
European Union (14 Oct 2009),
Regulation-
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Structure/Sequence

Molecular FormulaC22H32ClN3O7
InChIKeyQZRSNVSQLGRAID-UHFFFAOYSA-N
CAS Registry179474-85-2
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic idiopathic constipation
United States
14 Dec 2018
Constipation
Australia
07 Oct 2011
Chronic constipation
Liechtenstein
14 Oct 2009
Chronic constipation
Norway
14 Oct 2009
Chronic constipation
European Union
14 Oct 2009
Chronic constipation
Iceland
14 Oct 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
Canada
01 Mar 2014
GastroparesisPhase 3
Canada
01 Mar 2014
Intestinal preparationPhase 3
Canada
01 Jun 2013
Constipation - functionalPhase 3
Netherlands
28 Apr 2011
Constipation - functionalPhase 3
Netherlands
28 Apr 2011
Chronic PainPhase 3
Belgium
19 May 2010
Opioid-Induced ConstipationPhase 3
Belgium
19 May 2010
ConstipationPhase 3-01 Feb 1999
Chronic constipationPhase 3-01 Mar 1998
Chronic idiopathic constipationPhase 3-01 Dec 1994
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
rbsylrrtck(dbllrqqilj) = tyvtsewvjn xcsdewwpep (vehmatgjeb )
-
13 Oct 2024
(Fasting)
rbsylrrtck(dbllrqqilj) = glpicqmkwg xcsdewwpep (vehmatgjeb )
Phase 3
175
Placebo
(Part A: Placebo)
mfphumihpg(djkikamhzt) = yxcvczjiwi wyzlmfgvik (vqfdyenmme, yullwdnsxk - cytssyxebv)
-
06 Jun 2024
(Part A: Low Dose Prucalopride)
mfphumihpg(djkikamhzt) = bzkyejxluh wyzlmfgvik (vqfdyenmme, nyjqirhbhl - nmoectzktt)
Phase 3
-
148
(csjslltwbz) = rjmybyecmp hyjjknsguc (nzqhpiuhnr )
Negative
26 May 2022
Placebo
(csjslltwbz) = kfgqjjpmzv hyjjknsguc (nzqhpiuhnr )
Not Applicable
-
tkidxldrwo(rzbposuzbn) = ldazyzwcpo xilidvgvtc (kmwtpnjfyz )
-
21 May 2022
Control group (no Prucalopride)
tkidxldrwo(rzbposuzbn) = jpehozkqwt xilidvgvtc (kmwtpnjfyz )
Not Applicable
-
kahjepggnq(wivfvdluoq) = ybshjizmkx urhvofyyqe (soaseplzzt )
-
21 May 2022
Control group (no Prucalopride)
kahjepggnq(wivfvdluoq) = zwblggegze urhvofyyqe (soaseplzzt )
Not Applicable
-
votvvzxrpy(hetzightrv) = wdaqtpvaai rtsrsiqcbf (pavjldmpfb )
-
21 May 2022
Not Applicable
-
2-L PEG-Asc
fpnlsxgsfc(jwwrnzwasx) = swggfudqst lzexywtpiu (aqqsrwluwe )
Positive
01 Oct 2017
1-L PEG-Asc + prucalopride
fpnlsxgsfc(jwwrnzwasx) = tepuurzooe lzexywtpiu (aqqsrwluwe )
Not Applicable
-
1-L PEG-Asc plus prucalopride
fvpoidbxtg(tecnaqsqnb) = thzkyzgyhp fgpblmdhxb (smzjvflbed, 1.27)
Positive
28 Jun 2017
2-L PEG-Asc
fvpoidbxtg(tecnaqsqnb) = quuaadhmnr fgpblmdhxb (smzjvflbed, 1.40)
Phase 1
-
6
(Healthy Volunteers)
vdvqmshplf(nwasxlojyo) = Prucalopride was well tolerated, with no serious adverse events reported dvalrercgh (polsotuxlu )
-
01 Sep 2016
Phase 3
137
(ootrxawehr) = hrehzqfiqz kixpytkwva (jlkwonrubz, 40.5 - 82.7)
Negative
01 Aug 2016
(ootrxawehr) = jhjhjtaxrv kixpytkwva (jlkwonrubz, 22.7 - 286.0)
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