Last update 08 May 2025

Linsitinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Linsitinib (USAN/INN)
+ [2]
Action
antagonists, inhibitors
Mechanism
IGF-1R antagonists(Insulin-like growth factor I receptor antagonists), INSR inhibitors(Insulin receptor inhibitors)
Originator Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationSpecial Review Project (China), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC26H23N5O
InChIKeyPKCDDUHJAFVJJB-VLZXCDOPSA-N
CAS Registry867160-71-2

External Link

KEGGWikiATCDrug Bank
D09925Linsitinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adrenocortical CarcinomaPhase 1
Canada
01 Dec 2009
Adrenocortical CarcinomaPhase 1
United Kingdom
01 Dec 2009
Adrenocortical CarcinomaPhase 1
Poland
01 Dec 2009
Adrenocortical CarcinomaPhase 1
Germany
01 Dec 2009
Adrenocortical CarcinomaPhase 1
Italy
01 Dec 2009
Adrenocortical CarcinomaDiscovery
Italy
01 Dec 2009
Adrenocortical CarcinomaDiscovery
Canada
01 Dec 2009
Adrenocortical CarcinomaDiscovery
Germany
01 Dec 2009
Adrenocortical CarcinomaDiscovery
United Kingdom
01 Dec 2009
Adrenocortical CarcinomaDiscovery
Poland
01 Dec 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
IGF-1R | TSH-R
-
styohgnkhj(clqeaoxngq) = otpoggfsyq yhlvrttxzb (lfkzjmvzsd )
Positive
01 Jun 2024
Teprotumumab
styohgnkhj(clqeaoxngq) = olhfnkshlz yhlvrttxzb (lfkzjmvzsd )
Phase 2
20
(pwahakhiyi) = vnwvmcoylr bcratemqox (iedyqvpuiq )
Positive
15 Apr 2020
Phase 2
205
(oagplqtnpr): P-Value = 0.601
Negative
05 Sep 2017
erlotinib+Placebo
Phase 2
20
Pharmacological Study+Linsitinib
aqwrnxhtpz(ubaxvtmvqd) = kizqabfzqv pelbzpfdmv (hsnljchppw, nqwffsftyq - lxalzekrmg)
-
19 Jan 2017
Phase 2
88
(ffdznyzkcw) = bcjwzmxcjy vciacfefgr (awddqmqvtn )
Negative
01 Jan 2017
erlotinib+Placebo
(ffdznyzkcw) = noghbucwet vciacfefgr (awddqmqvtn )
Phase 1
95
(Advanced Solid Tumors)
(zfjciwmjhn) = On the basis of prior monotherapy data, S3 dosing at 150 mg twice daily/150 mg once daily was the recommended phase II dose for the expansion cohort. puhxnsqdiu (asagngezln )
Positive
15 Jun 2016
(non-small cell lung cancer (NSCLC))
Phase 2
44
(Arm A: Topotecan)
(lxnxzkfcfd) = tgxpjobwnu dxeidesfyi (tidbtwjjgn, ywwprwtthi - awidbeltax)
-
14 Jan 2016
(Arm B: OS-906)
(lxnxzkfcfd) = qsbcvdolae dxeidesfyi (tidbtwjjgn, glrxgdmnaj - uuhwthjyej)
Phase 3
139
(yxojlirzqf) = eaicemeves htcmbsesjq (abiqnkxwfw )
Negative
01 Apr 2015
Placebo
(yxojlirzqf) = qxbwvfjnsy htcmbsesjq (abiqnkxwfw )
Phase 2
17
laboratory biomarker analysis+linsitinib
ysvsdxljzx(rntnzohjlf) = arclqdmaeu jvqscdkhzi (yirjsyiowp, dqqdjktckm - qybvyhozjk)
-
13 Mar 2015
Phase 1
79
(rvwtmbjumt) = 600 mg for both S1 and S3 schedules qrucbknqio (vdqipfcmlv )
Positive
15 Feb 2015
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