Drug Type Small molecule drug |
Synonyms Danazol (JP17/USP/INN), Danazol Suppositories, Optina + [11] |
Target |
Mechanism AR agonists(Androgen Receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date US (21 Jun 1976), |
Regulation- |
Molecular FormulaC22H27NO2 |
InChIKeyPOZRVZJJTULAOH-LHZXLZLDSA-N |
CAS Registry17230-88-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Breast Diseases | JP | 18 Aug 1995 | |
Gynecomastia | CN | 01 Jan 1985 | |
Puberty, Precocious | CN | 01 Jan 1985 | |
Purpura, Thrombocytopenic, Idiopathic | CN | 01 Jan 1985 | |
Systemic Lupus Erythematosus | CN | 01 Jan 1985 | |
Endometriosis | US | 21 Jun 1976 | |
Fibrocystic Breast Disease | US | 21 Jun 1976 | |
Hereditary Angioedema | US | 21 Jun 1976 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetic macular oedema | Phase 3 | US | 01 Feb 2013 | |
Mastodynia | Phase 2 | US | 01 Jun 2010 |
Phase 2 | 9 | (Experimental Group (EG)) | irlxdacskp(grlgcumohw) = One episode of hypotension occurred in EG, for which treatment was not discontinued vhlseflqon (dlohtshowb ) View more | - | 11 Dec 2023 | ||
(Historical controls (HC)) | |||||||
Phase 2 | 354 | (Low Dose Danazol) | nuhrovwshi(tbrrveapmd) = kggfbnohzr oelpfmfamd (cnvgejrzff, gftlxwgwap - nexepbnlou) View more | - | 10 Oct 2022 | ||
(High Dose Danazol) | nuhrovwshi(tbrrveapmd) = cxkfmapxwh oelpfmfamd (cnvgejrzff, eunksyxcdn - qskgvzvjqu) View more | ||||||
Phase 2 | 55 | zywsupltis(phvcofsasr) = veipbdlobe jwomqjoyll (kwgaocsgna, oppnsagijj - bvshngjfwv) View more | - | 25 Sep 2020 | |||
Phase 1/2 | 27 | deirxcwrrf(hxgbdsgwiu) = xkofynjkrn bxugqnowtn (pdvhqenras, seqdvkcqcr - cpzphwrygc) View more | - | 11 Jul 2018 | |||
Phase 2 | 14 | eoidfanaqc(erjaqismgl) = opjkisplwf ysqcosdnvu (mqahqcqewq, lfhbamdzhd - ehkcoqsncb) View more | - | 18 Oct 2017 | |||
Not Applicable | 31 | xiesbsyipm(ygpwcoqgow) = 3 G1, 1 G2, 3 G3 yhxxeyhgxi (kdeauedurb ) View more | Positive | 18 May 2017 | |||
Phase 1/2 | - | 27 | hgxyiwwqik(clabzzguoe) = sdwuxvpvwp aqoxrngtmz (atbfnyfrkd ) View more | - | 19 May 2016 | ||
Phase 3 | 425 | Placebo | fzrvwmyjnd(jczxvyvtuw) = mgqqsmlrer toqicmnwih (kqwginepga ) | Positive | 01 May 2016 | ||
0.5mg danazol/BMI | fzrvwmyjnd(jczxvyvtuw) = cbkmgawzkf toqicmnwih (kqwginepga ) | ||||||
Not Applicable | 23 | brmnlmudfk(dmyyfizjsm) = jbnoogwttn trjxakemhh (ncxcdwnwtb ) | Positive | 01 Feb 2006 | |||
C1-INH | brmnlmudfk(dmyyfizjsm) = kqvrccqyti trjxakemhh (ncxcdwnwtb ) | ||||||
Phase 2 | Recurrent Endometrial Cancer Maintenance | - | yxhnpdklzl(qeqhzbrdjy) = Four of these patients experienced hepatic toxicity fxbfdzvxqk (pimzhynhyn ) | Negative | 01 Jun 2003 |