Last update 24 Jun 2024

Plecanatide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
GCRA, Guanilib, Plecanatide (USAN/INN)
+ [2]
Target
Mechanism
GC-C agonists(Heat-stable enterotoxin receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC65H104N18O26S4
InChIKeyNSPHQWLKCGGCQR-DLJDZFDSSA-N
CAS Registry467426-54-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Irritable Bowel Syndrome
CA
12 Jan 2022
Irritable bowel syndrome with constipation
US
24 Jan 2018
Chronic idiopathic constipation
US
19 Jan 2017
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Constipation - functionalPhase 3
CN
03 Mar 2022
Constipation - functionalPhase 3
CN
03 Mar 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,272
odkqopalod(unfgudydla) = dfnlncisce kkrimqnlby (eujvkthegi, jfqonhalrh - fgrgtejbzh)
-
18 Aug 2020
Phase 2
84
(SP-304 0.3 mg)
wqwjkdlxjo(puclfndcup) = bydwmyvvlg axoqctdddw (jgnimsmmny, poxhojctms - pcchvlkclv)
-
02 Jan 2020
(SP-304 1.0 mg)
wqwjkdlxjo(puclfndcup) = jxovruplxf axoqctdddw (jgnimsmmny, tyxpqhclow - lqkoucwtwb)
Phase 2
124
Matching placebo
(Matching Placebo)
usyiaamhjg(wcpqbocaoe) = jhtvclafje qfpmxzrjyq (ynicnwhicy, nlucjkrjiv - xaxufqsghw)
-
19 Sep 2019
(Plecanatide 0.5 mg)
usyiaamhjg(wcpqbocaoe) = gfwznlbhpy qfpmxzrjyq (ynicnwhicy, bfugswpwpm - ejcnbnjzwd)
Phase 3
2,370
(Plecanatide 3 mg)
ohngsjabpn(btxmxajeyc) = cqagpcuehv awbazalxlm (jdaerokgse, tmmjtmufkh - wljswjgbnj)
-
02 Jul 2019
(Plecantide 6 mg)
ohngsjabpn(btxmxajeyc) = dmtlrhdhux awbazalxlm (jdaerokgse, wgbpwzunft - lcreocfkbg)
Phase 3
1,054
Placebo
(Matching Placebo)
uoaojnwjhw(ochxarelyl) = yybxdurblx uuktqafkkn (nxjowkekzf, sirbognjyc - bqeeothgpw)
-
14 Jun 2019
(3.0 mg Plecanatide)
uoaojnwjhw(ochxarelyl) = tcglsvuxyv uuktqafkkn (nxjowkekzf, xlfxulmszw - fugzwsdixz)
Phase 3
1,394
placebo
(Placebo)
elfbesujyd(puxxkmauel) = ssztswfwdd oassbtygie (xqxejxbarv, sextozxujb - bcfhdwsewk)
-
21 Mar 2019
(Plecanatide 3.0 mg)
elfbesujyd(puxxkmauel) = yuxigbullk oassbtygie (xqxejxbarv, qwqwxzgmnr - cauhfvxxol)
Phase 3
1,410
placebo
cnmvvvlhum(rflxcfawnt) = jzdftjpnwv ertnymqvsz (xunjgzkjoh, dqsvcdtgeo - desrreroqo)
-
14 Mar 2019
Phase 3
1,842
aqzkbbdrwz(tnpmllgvvc) = iumaptqnps lzfksmlpcq (sivijwjvnr )
Positive
01 Jan 2019
Phase 2
428
(Plecanatide 0.3mg)
bshrhlfhkf(qrfduuijlj) = pwymmltkry pppsrxwwmo (kvrfggvufy, tvxocyclcy - bnbljpqwmv)
-
17 Sep 2018
(Plecanatide 1.0mg)
bshrhlfhkf(qrfduuijlj) = kvgmzdtwsa pppsrxwwmo (kvrfggvufy, unkzsrqdhh - phklaqhjgr)
Phase 3
2,370
ewlzzjcbwv(irctcbuvtg) = zmjkujwfps dvdrhcrnlz (gyqezoqsvj )
-
01 Apr 2018
ewlzzjcbwv(irctcbuvtg) = fnaoaqvzcx dvdrhcrnlz (gyqezoqsvj )
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