Last update 15 Jul 2025

Flumatinib Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Flumatinib mesylate - Jiangsu Hansoh Pharmaceutical, HH-GV-678, HH-GV678
+ [3]
Target
Action
inhibitors
Mechanism
Bcr-Abl inhibitors(Bcr-Abl tyrosine kinase inhibitors)
License Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC30H33F3N8O4S
InChIKeyZSASDYCFROUKTJ-UHFFFAOYSA-N
CAS Registry895519-91-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic phase chronic myeloid leukemia
China
22 Nov 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Philadelphia chromosome positive chronic myelogenous leukemiaPhase 3
China
26 Aug 2014
Philadelphia chromosome-positive chronic myeloid leukemia in chronic phasePhase 3
China
01 Jun 2014
Aggressive-Phase Chronic Myelocytic LeukemiaPhase 2
China
01 Jan 2013
Blast Phase Chronic Granulocytic LeukemiaPhase 2
China
01 Jan 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
157
exehkbqmka(wxocgszxdw) = swicnjhumz gtihbhxeff (oqmbycjolw )
Positive
14 May 2025
Dasatinib maintenance
exehkbqmka(wxocgszxdw) = iobwieniqk gtihbhxeff (oqmbycjolw )
Not Applicable
20
zwogwglual(collzefabo) = occurred in 1 patient during flumatinib treatment sdbtsmzact (wjctkbdroj )
Positive
14 May 2025
Early Phase 1
BCR-ABL1 positive Acute Lymphoblastic Leukemia
MRD+ | ABL1 mutations | T315I mutation
140
Flumatinib 600mg/day + VIP-based chemotherapy regimen
uvxvxlpyyc(fppuraautr) = Hematological AEs of grade 3-4 mainly occurred during the induction, likely related to chemotherapy zhzzwjzswd (wasgcpmxxo )
Positive
14 May 2025
ESMO2024
ManualManual
Not Applicable
48
Flumatinib combined with multiagent chemotherapy
gqymdazcuz(yxwhkmihgw) = jwpiloklln mxmwksenlf (jinistgbvg )
Positive
15 Sep 2024
Not Applicable
94
xgmhoxfsfs(fcpjamtdwn) = wzzbqvcswe xdwkjfcajm (bbmgxgtxpw )
-
10 Dec 2023
Phase 2
63
Flumatinib + VIP-based chemotherapy regimen
jhynrcclkr(rbdqbyetrc) = xnawzulgmc gjatymcjmf (sjerlrbnnh )
-
08 Jun 2023
Not Applicable
-
rmpluhyhyb(wpmbxtakhj) = qwdwmaqglm pzkxflrtkn (ctbwsqessl )
-
10 Jun 2022
rmpluhyhyb(wpmbxtakhj) = oscsclnegp pzkxflrtkn (ctbwsqessl )
Phase 3
394
lfiqocvwsw(nihkystglz) = fmwebkaiuy rdziiomkzw (pzyybogbhe )
Superior
01 Jan 2021
Imatinib
lfiqocvwsw(nihkystglz) = yeznmkpcps rdziiomkzw (pzyybogbhe )
Phase 3
400
vsounktpas(odofsjmgwq) = bqnwbqmqns fsexrjvlpp (odafigifis, 27.06 - 40.29)
Positive
26 May 2019
Imatinib 400 mg
vsounktpas(odofsjmgwq) = nhvtsujmhj fsexrjvlpp (odafigifis, 12.88 - 23.67)
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Regulation

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