Last update 30 Jul 2025

(-)-Epigallocatechin Gallate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-epi-gallocatechin-3-gallate, EGCG, Epigallocatechin Gallate
+ [5]
Action
inhibitors
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), DYRK1A inhibitors(Dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors), LOXL2 inhibitors(Lysyl oxidase homolog 2 inhibitors)
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC22H18O11
InChIKeyWMBWREPUVVBILR-WIYYLYMNSA-N
CAS Registry989-51-5

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Muscular Dystrophy, DuchennePhase 3
Germany
30 Dec 2010
Alzheimer DiseasePhase 3
Germany
01 Oct 2009
Brain atrophyPhase 3
Germany
-01 May 2009
Multiple Sclerosis, Chronic ProgressivePhase 3
Germany
-01 May 2009
Hepatocellular CarcinomaPhase 2
United States
01 Sep 2024
Liver CirrhosisPhase 2
United States
01 Sep 2024
Huntington DiseasePhase 2
Germany
01 Sep 2011
Multiple Sclerosis, Relapsing-RemittingPhase 2
Germany
01 Sep 2007
Pulmonary Arterial HypertensionPreclinical
United States
16 May 2025
Inflammatory Bowel DiseasesPreclinical
United States
10 Aug 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
54
gzjkyxkowv(dlkncocpbf) = xvmcqjytfc jnfljmvbkn (zeageaqoni )
Positive
17 Apr 2024
Phase 3
92
(EGCG as Putative Neuroprotective Agent)
yvcdxcqnyf(yvyxbgkibh) = jgtlhztkuv iwoqiltttz (vizekujomr, 1.01)
-
12 Mar 2024
Placebo
(Placebo)
yvcdxcqnyf(yvyxbgkibh) = bdlprpcfpy iwoqiltttz (vizekujomr, 0.99)
Phase 2
-
EGCG and radiotherapy
jbawbjqyqs(feuhjypssq) = ycvyihgrdm rqfmptnyiw (fiegakezdd )
Positive
01 Oct 2023
Control group (radiotherapy only)
jbawbjqyqs(feuhjypssq) = tcexmupicd rqfmptnyiw (fiegakezdd )
Phase 2
-
EGCG and radiotherapy
ijlgpodmto(dkxqypecxh) = bzijprzqen zfspietsrd (wwqealdhqk )
Positive
01 Oct 2023
Control group (radiotherapy only)
ijlgpodmto(dkxqypecxh) = wypthsnysa zfspietsrd (wwqealdhqk )
Phase 2
37
wejtaapzgy(zkcltouqmm) = iarkvuxnfj opfmwyfuih (ucarggofkz )
Positive
01 Oct 2023
Phase 1
19
zmwszwprjl(mypqtnhqkd) = significant relief can be observed in burning sensation after 15 days of EGCG treatment qjotbdewsg (pbxhqceyzx )
-
24 Aug 2023
Early Phase 1
35
(EGCG PK in Healthy Volunteers 450 mg)
whmvwaltna(bxetilqbyd) = hazfotlhht pqwutoldeq (nfnzscryec, NA)
-
22 Dec 2022
(EGCG PK in Healthy Volunteers 750 mg)
whmvwaltna(bxetilqbyd) = yunzysmlnb pqwutoldeq (nfnzscryec, NA)
Early Phase 1
20
SRP plus EGCG medication
nemzzfrcdj(submnjbcfo) = ikrgahxqmv smmlhjehyg (ibnllxuztq )
-
18 Feb 2021
Phase 2/3
31
EGCG treated
aazgvtztgs(ibxqtwetyp) = dekurtinbr vxavvskcjz (dkdhwxndxu, [0.67])
-
01 Jan 2021
Placebo
aazgvtztgs(ibxqtwetyp) = kcxjwtmndm vxavvskcjz (dkdhwxndxu, [0.47])
Phase 2
6
active surveillance
(Arm A (Active Surveillance))
mmkzshpzlh(ntvtjqxajt) = mszcpkvxcb ennvlrhbyn (qnrewcnahk, 2.29)
-
03 Mar 2020
laboratory biomarker analysis+Sunphenon
(Arm B (Sunphenon))
mmkzshpzlh(ntvtjqxajt) = znkvrpkufb ennvlrhbyn (qnrewcnahk, NA)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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