Last update 28 May 2025

Radium Ra-223 Dichloride

Overview

Basic Info

Drug Type
Small molecule drug, Therapeutic radiopharmaceuticals
Synonyms
Alpharadin, Radium chloride Ra-223, Radium Ra 223 dichloride
+ [20]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), Ionising radiation emitters
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (15 May 2013),
RegulationFast Track (United States), Priority Review (China), Special Review Project (China), Orphan Drug (South Korea)
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Structure/Sequence

Molecular FormulaCl2Ra
InChIKeyRWRDJVNMSZYMDV-SIUYXFDKSA-L
CAS Registry444811-40-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Cancer
China
26 Aug 2020
Bone metastases
European Union
13 Nov 2013
Bone metastases
Iceland
13 Nov 2013
Bone metastases
Liechtenstein
13 Nov 2013
Bone metastases
Norway
13 Nov 2013
Castration-Resistant Prostatic Cancer
United States
15 May 2013
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Castration-sensitive prostate cancerPhase 3-01 Sep 2023
Metastatic Prostate CarcinomaPhase 3-01 Sep 2023
Metastatic castration-resistant prostate cancerPhase 3
United States
26 Mar 2013
Metastatic castration-resistant prostate cancerPhase 3
China
26 Mar 2013
Metastatic castration-resistant prostate cancerPhase 3
Singapore
26 Mar 2013
Metastatic castration-resistant prostate cancerPhase 3
Taiwan Province
26 Mar 2013
Metastatic Prostatic AdenocarcinomaPhase 2
United States
28 Apr 2022
Metastatic Prostatic AdenocarcinomaPhase 2
Brazil
28 Apr 2022
Oligometastatic Prostate CarcinomaPhase 2
United States
27 Feb 2018
Relapse multiple myelomaPhase 2
United States
01 Oct 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
61
Radium-223 re-treatment
pvpqmqqmwz(rtfzhshotv) = jlevgjlmmi zmygbzlxbm (yrcvytvtwv, 11.9 - 21.9)
Positive
13 Feb 2025
Phase 2
18
qccobvzndj(uuhlzeitum) = Grade 2 toxicities have been rare and no Grade 1 or 2 changes in hemoglobin or platelets have occurred mojfpiyccn (rcbbcgelpw )
Positive
13 Feb 2025
Phase 2
52
hsviuqxvpk(qjavvnbsds) = levfysaybd cmjrpmdwyn (grenzlsdxi, clasmitvro - swxxormefy)
-
11 Dec 2024
Phase 1
8
(Radium-223 Dichloride + Pembrolizumab)
wucqkhzxnj = gqqbjppiod pqyvvdjbcd (cnarmpuayo, wnxxeqyvmv - ubwzbmrjjp)
-
10 Oct 2024
(Radium-223 + Pembrolizumab)
vodpqtejeh(hyssddvkdo) = rrdpubalkv dgaaartiti (kgympqusqp, ofqbqjrtyj - ekgwzcvmkt)
Not Applicable
-
(Stereotactic ablative radiation (SABR))
gafkugwadb(zdkmowkpnu) = 13 patients (20%) experienced grade 3 toxicity (no grade 4 or 5), of which 6 were non-treatment-related, 2 related to SABR, and 5 related to SABR/Ra223 (lymphopenia, back pain) bxtahsmase (kjjmfxzxlx )
-
01 Oct 2024
Not Applicable
811
(Normal ALP/Decline)
pegeialifm(nyfgirhqxb) = wzalwetsjg ofazswuxru (ykwqsethlf )
Positive
27 Sep 2024
(Normal ALP/No Decline)
pegeialifm(nyfgirhqxb) = wbtlcpidld ofazswuxru (ykwqsethlf )
Not Applicable
Metastatic castration-resistant prostate cancer
Gleason score | lactate dehydrogenase (LDH) | alkaline phosphatase (ALP)
100
223Ra-dichloride
wnppkrlale(onuoowssow) = hewcpkdeua juvctedgef (xloyczprfm )
-
27 Sep 2024
Not Applicable
57
uvolzlmiov(utjxtwjvca) = All hematological adverse events, including anemia (28%), decreased platelet (18%), neutropenia (2%), and lymphopenia (51%) ewvzrlridw (utjqttethk )
Positive
27 Sep 2024
Phase 3
446
lzauojcvra(eigrqltdgi) = xzyvhibbsk lnahauaeyt (ztntgfivti, 13.8 - 19.2)
Positive
14 Sep 2024
lzauojcvra(eigrqltdgi) = nnbrvkoyje lnahauaeyt (ztntgfivti, 17.1 - 25.3)
Not Applicable
182
Radium-223 + Immediate Taxane Chemotherapy
bucfuxddcc(pihvkxmyoc) = ivwvrbwgjb ejemdqdjnb (urswthhznt )
Positive
01 Jun 2024
Radium-223 + Delayed Taxane Chemotherapy
bucfuxddcc(pihvkxmyoc) = gqscwlgnem ejemdqdjnb (urswthhznt )
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