Delving into the Latest Updates on Gaxilose with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

4-galactosylxylose, Gaxilosa, LacTEST

Target

β-galactosidase

Action

modulators

Mechanism

β-galactosidase modulators(Beta-galactosidase modulators)

Therapeutic Areas

Congenital DisordersDigestive System DisordersEndocrinology and Metabolic Disease

Active Indication

Lactose Intolerance

Inactive Indication-

Originator Organization

Venter Pharma SL

Active Organization

Venter Pharma SL

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC11H20O10

InChIKeyBYZQBCIYLALLPA-NOPGXMAYSA-N

CAS Registry14087-31-1

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.

01 Jan 2021·Carbohydrate ResearchQ4 · CHEMISTRY

Characterization of crystalline forms of gaxilose, a diagnostic drug

Q4 · CHEMISTRY

Article

Author: Gallego, Santos Hernández ; Olóndriz, Francisco Marquillas ; Molins, Elies ; Catti, Federica ; Benito, Mónica

Lactose intolerance is a pathology caused by lactase enzyme deficiency, usually produced in the intestinal cells provoking symptoms as abdominal pain, bloating, diarrhea, gas and nausea. Gaxilose, 4-O-β-D galactopyranosyl-d-xylose, is used as a diagnostic drug for a non-invasive method for hypolactasia diagnosis. To date, no definitive guide for identifying gaxilose and distinguishing between crystalline forms is available. Data have been collected from a number of different analytical techniques in order to provide a full characterization of the compound and a simple method to discriminate between two solid forms.

15 Jun 2017·Journal of Computational ChemistryQ3 · CHEMISTRY

Rigidity and flexibility in the tetrasaccharide linker of proteoglycans from atomic‐resolution molecular simulation

Q3 · CHEMISTRY

Article

Author: Ng, Cathy ; Nandha Premnath, Padmavathy ; Guvench, Olgun

Proteoglycans (PGs) are covalent conjugates between protein and carbohydrate (glycosaminoglycans). Certain classes of glycosaminoglycans such as chondroitin sulfate/dermatan sulfate and heparan sulfate utilize a specific tetrasaccharide linker for attachment to the protein component: GlcAβ1‐3Galβ1‐3Galβ1‐4Xylβ1‐O‐Ser. Toward understanding the conformational preferences of this linker, the present work used all‐atom explicit‐solvent molecular dynamics (MD) simulations combined with Adaptive Biasing Force (ABF) sampling to determine high‐resolution, high‐precision conformational free energy maps ΔG(φ, ψ) for each glycosidic linkage between constituent disaccharides, including the variant where GlcA is substituted with IdoA. These linkages are characterized by single, predominant (> 97% occupancy), and broad (45° × 60° for ΔG(φ, ψ) < 1 kcal/mol) free‐energy minima, while the Xyl‐Ser linkage has two such minima similar in free‐energy, and additional flexibility from the Ser sidechain dihedral. Conformational analysis of microsecond‐scale standard MD on the complete tetrasaccharide‐O‐Ser conjugate is consistent with ABF data, suggesting (φ, ψ) probabilities are independent of the linker context, and that the tetrasaccharide acts as a relatively rigid unit whereas significant conformational heterogeneity exists with respect to rotation about bonds connecting Xyl to Ser. © 2017 Wiley Periodicals, Inc.

100 Deals associated with Gaxilose

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB12767

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Lactose Intolerance	Spain	Venter Pharma SL	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


UEGW2014	Not Applicable	Lactose Intolerance	-	GAXILOSE (Hydrogen breath test with lactose)	(noiytedymh) = nokmxvmlbm akqfybxvyu (hzrtvijbty ) View more	-	01 Oct 2014