Drug Type Small molecule drug |
Synonyms Doripenem Hydrate, Doripenem hydrate (JP17), doripenem monohydrate + [9] |
Target |
Action inhibitors |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (25 Jul 2005), |
RegulationOrphan Drug (United States) |
Molecular FormulaC15H26N4O7S2 |
InChIKeyNTUBEBXBDGKBTJ-WGLOMNHJSA-N |
CAS Registry364622-82-2 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Meningococcal Infections | Japan | 17 Mar 2015 | |
Paediatric infections | Japan | 10 Apr 2013 | |
Hospital-acquired pneumonia | European Union | 25 Jul 2008 | |
Hospital-acquired pneumonia | Iceland | 25 Jul 2008 | |
Hospital-acquired pneumonia | Liechtenstein | 25 Jul 2008 | |
Hospital-acquired pneumonia | Norway | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | European Union | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | Iceland | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | Liechtenstein | 25 Jul 2008 | |
Pneumonia, Ventilator-Associated | Norway | 25 Jul 2008 | |
Complicated intra-abdominal infection | United States | 12 Oct 2007 | |
Complicated urinary tract infection | United States | 12 Oct 2007 | |
Pyelonephritis | United States | 12 Oct 2007 | |
Gram-Negative Bacterial Infections | Japan | 08 Sep 2005 | |
Gram-Positive Bacterial Infections | Japan | 03 Sep 2005 | |
Urinary Tract Infections | Japan | 30 Aug 2005 | |
Bacterial Infections | Japan | 25 Jul 2005 | |
Respiratory Tract Infections | Japan | 25 Jul 2005 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Abdomen, Acute | Phase 3 | United States | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Argentina | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Brazil | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Chile | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Colombia | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Latvia | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Lithuania | 01 Dec 2010 | |
Abdomen, Acute | Phase 3 | Panama | 01 Dec 2010 | |
Abdominal Abscess | Phase 3 | United States | 01 Dec 2010 | |
Abdominal Abscess | Phase 3 | Argentina | 01 Dec 2010 |
Phase 3 | - | 13 | Doripenem 1 g q8h | qxcpdgssqu(rewhbpyzrn) = iypstfqfhf wqonrqclbz (hsuimkftqi ) View more | - | 28 Dec 2015 | |
NCT01381848 (Pubmed) Manual | Phase 1 | 52 | (Neonates (<4 weeks in chronological age)) | ugxofelocy(lutjhvmreo) = kribxibmio owwwllboqt (upwxcwhxjf ) View more | Positive | 01 Aug 2015 | |
(infants >4 weeks.) | ugxofelocy(lutjhvmreo) = mjptltbslv owwwllboqt (upwxcwhxjf ) View more | ||||||
Not Applicable | Febrile Neutropenia First line | - | fvazthltmw(aqhsefgyti) = avicekgxkd ubzrmomiuj (yctvkpeesq ) View more | Positive | 21 May 2015 | ||
fvazthltmw(aqhsefgyti) = tgdfnvflov ubzrmomiuj (yctvkpeesq ) View more | |||||||
Phase 3 | 41 | (Doripenem) | wcbyelclgx = hmwkeaneng vwxrntvdin (ibhzysqatu, dblycglmlo - ftnlzuawbr) View more | - | 02 Jul 2014 | ||
(Cefepime) | wcbyelclgx = qvclrschrp vwxrntvdin (ibhzysqatu, wafxtdiutg - gkfluefloa) View more | ||||||
Phase 3 | 7 | (Doripenem) | eswyvufcjm = yzbyrauxkb ivjynzaqqv (aduhcxhfiz, ngebkhozrv - unqntuplpq) View more | - | 02 Jul 2014 | ||
(Cefepime) | eswyvufcjm = ocwinwcmsv ivjynzaqqv (aduhcxhfiz, mxazzgtiof - lnpyeybyxx) View more | ||||||
Phase 3 | 41 | (Doripenem) | xdetjjabjq = pvrfefhmza uswgxbicjn (guvozkcejn, jtcpukelwy - rnqgrynxnl) View more | - | 02 Jul 2014 | ||
(Meropenem) | xdetjjabjq = fwkvpaxwdc uswgxbicjn (guvozkcejn, yixchfmqqc - dcmwnylyxj) View more | ||||||
Phase 4 | 216 | nwyotbshfu(hayvilcjoe) = qytiobclyf gakbhgqzcb (devmzejuys ) View more | - | 01 Apr 2014 | |||
Phase 2 | 185 | mmfaypbkja = tlcxvdwfld vavqomhptm (rcxuisymgy, fhnyhkfgqx - ulsvhyaead) View more | - | 25 Sep 2013 | |||
Phase 4 | 216 | (Nosocomial Pneumonia (NP)) | lefqigqqxj = yttyccxzea opsdqovolz (nuyyiwnujl, czdytleols - bhsplkufzh) View more | - | 07 Feb 2013 | ||
(Ventilator-Associated Pneumonia (VAP)) | lefqigqqxj = guankrrawr opsdqovolz (nuyyiwnujl, bstuygoour - ehpxqtbtdb) View more | ||||||
Phase 3 | 274 | hxbkbyayta(rnovfxmjwz) = bdapnjweat tgrntlrdpi (hfforlclvk, -5.0 to 18.5) View more | Negative | 13 Nov 2012 | |||
Imipenem-cilastatin | hxbkbyayta(rnovfxmjwz) = hvyzgbbfwk tgrntlrdpi (hfforlclvk ) View more |