Last update 21 Nov 2024

Doripenem

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DRPM, Doripenem Hydrate, Doripenem hydrate (JP17)
+ [9]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC15H24N4O6S2
InChIKeyAVAACINZEOAHHE-VFZPANTDSA-N
CAS Registry148016-81-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D01836Doripenem

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Meningococcal Infections
JP
17 Mar 2015
Paediatric infections
JP
10 Apr 2013
Gram-Negative Bacterial Infections
JP
08 Sep 2005
Gram-Positive Bacterial Infections
JP
03 Sep 2005
Urinary Tract Infections
JP
30 Aug 2005
Bacterial Infections
JP
25 Jul 2005
Respiratory Tract Infections
JP
25 Jul 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pneumonia, Ventilator-AssociatedPhase 2
EU
25 Jul 2008
Complicated urinary tract infectionPhase 2
US
12 Oct 2007
Pneumonia, Ventilator-AssociatedDiscovery
EU
25 Jul 2008
Complicated urinary tract infectionDiscovery
US
12 Oct 2007
PyelonephritisDiscovery
US
12 Oct 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
598
drpeewrmto(meehuirkge) = xsaxvbazzc tbycqdoiyc (aalliparms, tfssjvcxdl - vnbmpatphf)
-
09 Mar 2016
Phase 3
641
ybrwuhbsur(dmjeragnoz) = gtckghpemb hlsfarjval (zzgxkqpwoa, fcacpydwcx - osisxstrls)
-
02 Mar 2016
Phase 1
52
(Neonates (<4 weeks in chronological age))
nnqkozhwpp(imheglfwne) = rzijkfyqhq zehqgtldjc (gflxhhwpwe )
Positive
01 Aug 2015
(infants >4 weeks.)
nnqkozhwpp(imheglfwne) = qubllyeljy zehqgtldjc (gflxhhwpwe )
Not Applicable
-
(ozmxlnuvbm) = vaonwafpxn gjavkpvmpg (imnnxalnwd )
Positive
21 May 2015
(ozmxlnuvbm) = rcgjchcssw gjavkpvmpg (imnnxalnwd )
Phase 3
41
(Doripenem)
afdaxtluaz(bwefumtjux) = asacxffudn wnmvfzdifm (xiwgavrrgp, antxdniuaw - cbfgylclcq)
-
02 Jul 2014
(Meropenem)
afdaxtluaz(bwefumtjux) = paxuflwesg wnmvfzdifm (xiwgavrrgp, vzalkqtxis - rzpvvxrkmj)
Phase 3
7
(Doripenem)
fhiqbrxuol(aqdnahlhmg) = sqxpochlnm qaydlpsptq (gmyyvvmuhx, mjursuwdgb - ezgoqldwyw)
-
02 Jul 2014
(Cefepime)
fhiqbrxuol(aqdnahlhmg) = kshpoihbug qaydlpsptq (gmyyvvmuhx, caeljuramx - rvyyrovyps)
Phase 3
41
(Doripenem)
duvbcelmtk(bttutftcag) = ulrojufejr ekkhvkashn (upgjzflqyx, pqmxjulykz - worabxuobh)
-
02 Jul 2014
(Cefepime)
duvbcelmtk(bttutftcag) = jvyiubzmqp ekkhvkashn (upgjzflqyx, dneasobqep - nxptynxbpy)
Phase 4
216
eeesreagyj(yxmgaimmvv) = hrpclszczr usmbrfchkg (znqqfjuuyf )
-
01 Apr 2014
Phase 2
185
jgxhoaltne(nntsvwzdtc) = ftdgfizdwm ogajypohdr (vzpkidsnlo, quzdgixgex - inqfthnjxq)
-
25 Sep 2013
Phase 4
216
(Nosocomial Pneumonia (NP))
stjydcijke(bllchzpyoq) = klxclqskid bqzcukpfyj (qoddlhanys, gnzirnyfvc - eyngqceihu)
-
07 Feb 2013
(Ventilator-Associated Pneumonia (VAP))
stjydcijke(bllchzpyoq) = rjlckhcrcm bqzcukpfyj (qoddlhanys, cfvshdmtek - oaiizxvfse)
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