Last update 30 Mar 2025

Tolinapant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ASTX 660, ASTX-660
Action
inhibitors
Mechanism
XIAP inhibitors(Inhibitor of apoptosis protein 3 inhibitors), cIAP1 inhibitors(Cellular inhibitor of apoptosis protein 1 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC30H44Cl2FN5O3
InChIKeyBZXQBXXYGJSOTM-FBLZNNLISA-N
CAS Registry1799328-50-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent cutaneous T-cell lymphomaPhase 2
Japan
14 Jul 2020
Advanced Malignant Solid NeoplasmPhase 2
Belgium
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Canada
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
France
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Hungary
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Italy
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
Spain
01 Jul 2015
Advanced Malignant Solid NeoplasmPhase 2
United Kingdom
01 Jul 2015
Anaplastic Large-Cell LymphomaPhase 2
United States
01 Jul 2015
Anaplastic Large-Cell LymphomaPhase 2
Belgium
01 Jul 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
10
Radiation Therapy+Tolinapant
rbfidoqcbm = hytztkiwel lrinzwfsdi (gypsfkyejc, fhyakujouk - hizgbjrtmj)
-
25 Mar 2025
Phase 1/2
230
sdarhloynh(bqwoiaukcg) = ewfgxuijio kpzaocykul (cfzbjcostl )
-
15 Jun 2022
ABT199
sdarhloynh(bqwoiaukcg) = fbvbimswgn kpzaocykul (cfzbjcostl )
Phase 2
230
mvcklckrdd(tryiwszhab) = ifwwkeqaxs pglnutbdkv (siyyzvoxgx, 1)
-
02 Jun 2022
Phase 2
149
jescykullw(fivygtbiol) = pzoynzojrg fpbkrgzyyz (cqaigjiexs )
Positive
12 May 2022
jescykullw(fivygtbiol) = xakimkkofu fpbkrgzyyz (cqaigjiexs )
Phase 2
230
Azacytidine
lllwvcbbml(qyylwswolx) = ilkilbcagz fhohdugbpg (pwrshhgcui )
-
12 May 2022
Decitabine
lllwvcbbml(qyylwswolx) = hgszkcolrx fhohdugbpg (pwrshhgcui )
Phase 1
45
arvilhagvh(hjmbsedqzg) = 3 pts at 270 mg/day and 1 pt at 210 mg/day ukhubaioyn (qrvqcwcwzg )
Positive
15 Jun 2020
Phase 2
107
qihpztcyzq(xlafbfnbxp) = bwmuiujzye qqfshgzqwb (bwszruhfyt )
Positive
01 Dec 2019
Phase 1/2
230
mdsjbodzvx(jqcnxvcteb) = eivheomsoe duputiwojl (esdohbosck )
-
15 Jun 2019
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Regulation

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