Last update 03 Nov 2024

ZN-A-1041

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
RG-6596, RG6596, ZN A 1041
+ [4]
Target
Mechanism
HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationBreakthrough Therapy (CN)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
CN
15 Oct 2020
HER2 Positive Breast CancerPhase 1
US
15 Oct 2020
HER2 Positive Breast CancerPhase 1
CN
15 Oct 2020
HER2 Positive Breast CancerPhase 1
AU
15 Oct 2020
HER2 Positive Breast CancerPhase 1
FR
15 Oct 2020
HER2 Positive Breast CancerPhase 1
NZ
15 Oct 2020
HER2 Positive Breast CancerPhase 1
ES
15 Oct 2020
HER2 Positive Breast CancerPhase 1
GB
15 Oct 2020
HER2 Positive Solid TumorsPhase 1
US
15 Oct 2020
HER2 Positive Solid TumorsPhase 1
CN
15 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Adjuvant
HER2-positive
202
vixeqlltaa(gservemufw) = Overall, 320 T-DM1-related AEs of any grade were registered in 105 pts (52%). G3 AEs were observed in 11 pts (5.4%), while there were no G4-G5 AEs. Most prevalent AEs of any grade were transaminases increase (19.8%), thrombocytopenia (15.3%), nausea and vomiting (13.3%), fatigue (10.9%), myalgia and arthralgia (7.4%), peripheral neuropathy (6.4%), and neutropenia (5%). For 42 out of 202 pts (20.8%), T-DM1 was reduced in dose, delayed or discontinued due to toxicity. opezpszfje (nfshumaxpb )
Positive
12 May 2023
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Regulation

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