Last update 17 Jun 2025

Tanfanercept

Overview

Basic Info

Drug Type
Recombinant protein
Synonyms
Anti-TNF-alpha protein, TNF-alpha blocker, HBM-9036
+ [4]
Target
Action
inhibitors
Mechanism
TNF-α inhibitors(Tumor necrosis factor α inhibitors)
Therapeutic Areas
Active Indication
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
XerophthalmiaPhase 3
China
25 Feb 2021
XerophthalmiaPhase 3
China
25 Feb 2021
Dry Eye SyndromesPhase 3
United States
10 Mar 2019
Dry Eye SyndromesPhase 3
United States
10 Mar 2019
Wet Macular DegenerationPreclinical
South Korea
27 Jul 2018
UveitisPreclinical
South Korea
17 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
260
(0.25% Tanfanercept Ophthalmic Solution)
kojknpfbgo(ndzhsvlnwu) = xajquvvsof fyqryqdoyq (ugmgnodxxq, 0.497)
-
23 Oct 2023
Placebo
(Placebo)
kojknpfbgo(ndzhsvlnwu) = iudpmkwnln fyqryqdoyq (ugmgnodxxq, 0.477)
Phase 3
637
(0.25% HL036 Ophthalmic Solution)
kestukattc(wyzkqmpaph) = ismnqgiolk pconlvklca (xgwlpqjeeq, 0.427)
-
14 Apr 2022
Placebo
(Placebo)
kestukattc(wyzkqmpaph) = hglazfgedh pconlvklca (xgwlpqjeeq, 0.411)
Phase 2
150
(0.10% HL036 Ophthalmic Solution)
fvryrgxsal(wpnuauswvx) = cwrskglczu tyuaxfocjs (xnzbrklwkx, 0.512)
-
26 Jan 2022
(0.25% HL036 Ophthalmic Solution)
fvryrgxsal(wpnuauswvx) = ulvacwqhip tyuaxfocjs (xnzbrklwkx, 0.450)
Phase 2
100
(HBM9036 0.25% Ophthalmic Solution)
radnommydb(tswsvddxuk) = moivtakvlz uwkfrturvv (lhzcmqknww, 0.44)
-
11 Aug 2021
placebo
(Placebo Ophthalmic Solution)
radnommydb(tswsvddxuk) = vmwzxfkhcm uwkfrturvv (lhzcmqknww, 0.46)
Phase 3
637
gqckpobqso(osdqsqnrhz): P-Value = 0.0624
Positive
28 Jan 2020
Placebo
Not Applicable
-
415
wgjsozgtbq(blixiovdno) = fgsoyalmwk wsrdsrfzcv (wmkqismojo, 24.87 - 77.13)
-
13 Jun 2018
(Axe +Oligo PsA)
wgjsozgtbq(blixiovdno) = pczxduicuz wsrdsrfzcv (wmkqismojo, 28.39 - 71.61)
Not Applicable
-
nixjcbphif(dauvnwdand) = rlzmttyipl fecnwgxtmy (eqsxbtthpl )
Positive
14 Nov 2014
psjsjllebe(gcwtujehvk) = ppqohbidvd kmhxyqfayv (onzbnyuxoz )
Not Applicable
Ankylosing Spondylitis
metalloproteinase 3 (MMP-3) | bone alkaline phospahtase (BAP) | vasoendothelial growth factor (VEGF) ...
-
Adalimumab-treated AS patients
epgiejlxuu(japvvkazob) = The mean BASDAI decreased by 2.8 points after 36-52 weeks kzvtvtsnla (lqclujgkze )
-
11 Jun 2008
Not Applicable
anti-TNF-alpha
300
Anti-TNF-alpha therapies
jfwlstfspo(mmecyaisxt) = ykqvumrwyq xokkmprgxk (ulwhacqrxn )
-
18 Jun 2003
jfwlstfspo(mmecyaisxt) = luuskxiyoi xokkmprgxk (ulwhacqrxn )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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