The purpose of this study was to evaluate the effectiveness and safety of a single oral dose of NPS 1776 in the acute treatment of migraine pain and associated symptoms.

Start Date31 Dec 2003

Sponsor / Collaborator

Shire Plc

100 Clinical Results associated with Isovaleramide

100 Translational Medicine associated with Isovaleramide

100 Patents (Medical) associated with Isovaleramide

265

Literatures (Medical) associated with Isovaleramide

01 May 2025·Food Chemistry

Impact of the drying process on the flavor characteristics of two economically important laver species, Pyropia haitanensis and Neopyropia yezoensis

Article

Author: Wang, Tiegan ; Zhang, Yuting ; Chen, Juanjuan ; Yang, Rui ; Luo, Qijun ; Huang, Yongbo ; Chen, Haimin ; Zhang, Peng

This study investigated the impact of drying process on the flavor profiles of the economically significant Pyropia haitanensis and Neopyropia yezoensis, aiming to clarify how species differences and drying process influence volatile and non-volatile flavor compounds. Using GC × GC-TOFMS and LC-MS, the volatile metabolites, free amino acids (FAAs), and nucleotides were analyzed. A total of 2774 volatile components, including 76 odor-active compounds (OACs), were identified, with aldehydes, ketones, benzenoids, and pyrazines as dominant contributors. The key volatiles responsible for their unique flavor were 2-nonenal, 2-octenal, heptanal, 2-pentylfuran, and 1-octen-3-one. Fresh P. haitanensis exhibited a superior flavor profile due to higher OACs and umami compounds, while high-temperature drying significantly enhanced the umami and sweet flavor notes in N. yezoensis by increasing aromatic volatiles and umami FAAs. These findings demonstrate that species differences and processing methods significantly influence laver flavor, providing valuable insights for improving product quality.

01 Mar 2025·Brazilian Journal of Microbiology

Exploration of endophytic and rhizospheric bacteria of invasive plant Xanthium strumarium L. reveals their potential in plant growth promotion and bacterial wilt suppression

Article

Author: Das, Priyanka ; Agarwala, Niraj ; Kashyap, Sampurna ; Sharma, Indrani ; Ray, Suvendra Kumar

Plant-associated microbiome plays important role in maintaining overall health of the host plant. Xanthium strumarium displaying resilience to various environmental fluctuations may harbor some bacterial isolates which can help this plant to grow worldwide. The present study aims to isolate endophytic and rhizospheric bacteria from X. strumarium and assess their plant growth-promoting and Ralstonia solanacearum antagonism activity. From a total of 148 isolated bacteria, 7 endophytic and 2 rhizospheric bacterial isolates were found to endow with significant in vitro plant growth promotion activities. The 16S rRNA gene sequence similarity of the 7 endophytic isolates has revealed these bacteria belonging to 5 genera viz. Curtobacterium, Pantoea, Pseudomonas, Microbacterium and Paracoccus whereas, the two rhizospheric isolates were identified as species of Ralstonia pickettii and Priestia megaterium. Maximum growth promotion was observed using the strains Pseudomonas fluorescens XSS6 and Microbacterium hydrothermale XSS20 in the assay conducted on tomato plants. In the in planta inhibition assay of R. solanacearum carried out in tomato seedlings using root bacterization method, Pseudomonas fluorescens XSS6 and Panotea vagans XSS3 showed antagonistic activity with biocontrol efficacy of 94.83% and 83.96%, respectively. GC-MS analysis detected several known antimicrobial compounds in the extract of the culture supernatant of Pseudomonas fluorescens XSS6 and Panotea vagans XSS3 strains, which may contribute to the inhibition of R. solanacearum by these strains. The results of our study indicated that the bacteria associated with X. strumarium exhibit multiple plant-beneficial effects. These bacteria have the potential to be developed as effective biofertilizers and biological control agents, promoting sustainable agriculture practices.

01 Dec 2024·Synthetic Communications

Synthesis and spectral characteristics of N -(2,2,2-trichloro-1-((5-(R-amino)-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides

Author: Ryabitsky, Aleksey B. ; Okhtina, Oxana V. ; Kiselev, Vadym V. ; Pavlova, Valeriia V. ; Zadorozhnii, Pavlo V. ; Kharchenko, Aleksandr V.

The development of an efficient and highly productive synthetic protocol for preparation of new 2,5-diamino-1,3,4-thiadiazole derivatives functionalized with N-(2,2,2-trichloroethyl)carboxamide group was reported.The method of their preparation was based on the reaction of oxidative dehydrosulfurization of N-(2,2,2-trichloro-1-(2-(phenylcarbamothioyl)hydrazine-1-carbothioamido)ethyl)carboxamides and N-(1-(2-carbamothioylhydrazine-1-carbothioamido)-2,2,2-trichloroethyl)benzamide under the action of a mixture of iodine and triethylamine in DMF.This reaction took place at room temperature for two hours and allowed obtaining the target products with a 69-75% yield.Using the developed protocol, ten new derivatives of 1,3,4-thiadiazole were obtained.Their structure was proven by IR,¹H NMR,¹³C NMR, ¹H-¹H COSY, ¹H-¹³C HSQC, ¹H-¹³C HMBC spectroscopy and LC/HRMS spectrometry.

100 Deals associated with Isovaleramide

External Link

KEGG	Wiki	ATC	Drug Bank
D04637	Isovaleramide	-	-

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Acute Kidney Injury	Preclinical	China	First Affiliated Hospital of Xinjiang Medical University	26 Sep 2024
Migraine Disorders	Discovery	United States	Shire Plc	31 Dec 2003

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis