Tofacitinib Citrate

Pluvicto ® PSMAddition oral presentation to highlight efficacy outcomes by disease volume and de novo/recurrent metastatic hormone-sensitive prostate cancer Kisqali ® NATALEE oral presentation to report prognostic and predictive impact of gene expression from largest biomarker CDK4/6i trial dataset Scemblix ® ASC4FIRST oral presentation to feature longer-term 144-week efficacy, safety and tolerability data in first-line Ph+ CML-CP New Novartis pipeline data, including Phase 3 ianalumab in ITP as well as Phase 1 actinium-based radioligand therapy, also to be presented Basel, May 21, 2026 – Novartis will present data from more than 65 company or investigator sponsored abstracts at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting and the European Hematology Association (EHA) 2026 Congress. “We are excited about sharing our latest advancements in radioligand therapy with new Pluvicto data and early insights from our actinium-based RLT,” said Mark Rutstein, MD, Global Head, Oncology Development, Novartis. “With a legacy of bold science, our Kisqali and Scemblix data offer continued evidence of how we meaningfully move cancer treatment forward for patients.” Key ASCO data highlights include: Abstract Title Abstract Number/ Presentation Details Pluvicto (lutetium Lu 177 vipivotide tetraxetan) Subgroup Analyses by Disease Volume and De Novo/Recurrent mHSPC in the PSMAddition Study of [ 177 Lu]Lu-PSMA-617 225 Ac-PSMA-617 AcTION: Phase 1 Study of [ 225 Ac]Ac-PSMA-617 (225Ac-PSMA-617) in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC) With or Without Prior [ 177 Lu]Lu-PSMA (177Lu-PSMA) Radioligand Therapy (RLT) Abstract # 5020 Rapid Oral May 31, 4:30pm – 6:00pm CDT Abstract # 5010 Oral June 1, 3:00pm – 4:30pm CDT Scemblix (asciminib) ASC4FIRST wk 144 Analysis: Efficacy and Safety and Tolerability With Asciminib (ASC) vs Investigator-Selected Tyrosine Kinase Inhibitors (IS TKIs) in Newly Diagnosed (ND) chronic myeloid leukemia in Chronic Phase (CML-CP) Abstract #6583 Poster June 1, 9:00am – 12:00pm CDT Kisqali (ribociclib) Prognostic and Predictive Impact of Baseline Gene Expression (Exp) in the NATALEE Trial of Adjuvant (Adj) Ribociclib (RIB) + Nonsteroidal Aromatase Inhibitor (NSAI) in HR+/HER2− Early Breast Cancer (EBC) Abstract #501 Oral May 30, 1:15pm – 4:15pm CDT Real-World (RW) Post-Progression Outcomes Following First-Line (1L) Ribociclib (RIB) + Aromatase Inhibitor (AI) Versus AI Alone in African American and Low Socio-Economic Status (SES) Patients (Pts) With Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative (HR+/HER2–) Metastatic Breast Cancer (MBC) in the US Abstract #1073 Poster June 1, 1:30pm – 4:30pm CDT Real-World (RW) Post-Progression Outcomes After First-Line (1L) Treatment With Ribociclib + an Aromatase Inhibitor (AI) vs AI Alone in US Patients With Hormone Receptor–Positive/Human Epidermal Growth Factor Receptor 2–Negative (HR+/HER2–) Metastatic Breast Cancer (MBC) Abstract # e13044 Online publication Key EHA data highlights include:  Abstract Title Abstract Number/ Presentation Details Scemblix (asciminib) ASC4FIRST wk 144 Analysis: Continued Superior Efficacy and Favorable Safety of Asciminib vs Investigator-Selected Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Abstract # S160 Oral June 11, 4:45pm – 6:00pm CEST Ianalumab (VAY736) Effect of Ianalumab Plus Eltrombopag on Patient-Reported Outcomes in Primary Immune Thrombocytopenia: Results From the VAYHIT2 Phase 3 Trial Abstract # PF1340 Poster June 12, 6:45pm – 7:45pm CEST Pelabresib (DAK539) Pelabresib Monotherapy in Myelofibrosis After Janus Kinase Inhibitor Failure: Results From Arm 1 of the Open-Label, Phase 2 MANIFEST Study Abstract # PS1987 Poster June 13, 6:45pm – 7:45pm CEST Rapcabtagene autoleucel (YTB323) Safety, Cellular Kinetics and Early Efficacy of Rapcabtagene Autoleucel (YTB323), a Rapidly Manufactured Autologous CD19 CAR-T Therapy, in Severe, Refractory Autoimmune Diseases Abstract # PF1241 Poster June 12, 6:45pm – 7:45pm CEST Fabhalta ® (iptacopan) Iptacopan demonstrates sustained efficacy and safety in paroxysmal nocturnal hemoglobinuria: up to 4 years of follow-up in patients from APPLY, APPOINT and roll-over extension program Abstract #PS1788 Poster June 13, 6:45pm – 7:45pm CEST Long-term hematologic control and safety in patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan: 6-year follow-up from phase 2 studies and roll-over extension program Abstract # PS1797 Poster June 13, 6:45pm – 7:45pm CEST Novartis in oncology The Novartis oncology strategy focuses on people living with cancer and those who care for them, from loved ones to clinical care teams, including their providers. For the past 30+ years, the aim has been to extend and improve lives by discovering differentiated, innovative and practice-changing medicines for patients. As Novartis reimagines medicine, it collaborates with a wide range of patient advocacy groups and supports education, early cancer screening and diagnosis. With a broad research and development portfolio across solid tumors, hematology and radioligand therapy (RLT), Novartis is committed to using technology, leading science and patient-centered research to deliver pioneering cancer care for all those in need. Disclaimer This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. 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Multicenter prospective RCT published in JAAD confirms superiority of XTRAC® Excimer Laser plus oral JAK inhibitors over tacrolimus combination therapy in children aged 2–18 years with progressive vitiligo, fueling continued market growth and expanding indications HORSHAM, Pa., May 18, 2026 (GLOBE NEWSWIRE) -- STRATA Skin Sciences, Inc. (“STRATA” or the “Company”), a global leader in excimer laser therapy dedicated to developing, commercializing, and marketing innovative products for the treatment of dermatologic conditions, today highlighted the publication of a landmark multicenter, prospective, randomized controlled trial in the Journal of the American Academy of Dermatology demonstrating that STRATA’s 308-nm excimer laser, when combined with oral JAK inhibitors, produces unprecedented repigmentation outcomes in pediatric patients with progressive vitiligo — with a favorable safety pro all 188 children enrolled over a 48-week treatment period. The study, conducted across five leading academic dermatology centers in China, enrolled children aged 2–18 years and compared two treatment arms: oral JAK inhibitors (baricitinib or tofacitinib) combined with 308-nm excimer laser therapy twice weekly (Group A) versus topical tacrolimus combined with the same excimer laser protocol (Group B). KEY STUDY FINDINGS Overall response rate of 85.5% in the JAK inhibitor + excimer laser group versus 53.8% in the tacrolimus + excimer laser control group (P95% repigmentation by week 48, compared to only 3 in the control arm Mixed-effects modeling confirmed a statistically significant 21.7% higher repigmentation rate for the JAK inhibitor + excimer laser combination (β = 0.217, 95% CI: 0.204–0.230, P<.001) All adverse events were mild to moderate in severity and fully resolved with appropriate management; no cases of tuberculosis or hepatitis B/C were observed Quality of life improvements, measured by the Children’s Dermatology Life Quality Index, were significantly greater in Group A, reaching statistical significance by week 48 (P<.001) “This publication is a powerful validation of our personalized medicine approach and confirms what we have long believed — that the XTRAC ® excimer laser is not just a stand-alone therapy, but an essential, synergistic component of next-generation combination regimens. XTRAC ® - 308-nm excimer laser served as the phototherapy backbone for both arms, underscoring its central and indispensable role in modern vitiligo combination therapy. ” said Dr. Dolev Rafaeli, President and CEO of STRATA Skin Sciences. “The unprecedented response rates seen here in children — a historically underserved and difficult-to-treat population — reinforce the growing body of peer-reviewed evidence supporting the XTRAC ® platform as the cornerstone of modern vitiligo care . We are proud to see our technology driving outcomes that meaningfully improve patients’ lives.” The mechanistic basis for these results reflects the complementary action of both therapies: JAK inhibitors suppress the upstream IFN-γ/JAK-STAT1 autoimmune signaling cascade that drives melanocyte destruction, while the 308-nm excimer laser simultaneously induces targeted apoptosis of pathogenic T cells at the dermo epidermal junction and actively promotes melanocyte migration and repopulation within lesional skin. Together, these mechanisms address both the immunological and cellular dimensions of vitiligo in a true personalized medicine approach. Intellectual Property Portfolio STRATA’s growing portfolio of patent applications is designed to support intellectual property protection and potential market exclusivity for combination therapies involving its XTRAC ® excimer laser when used with JAK inhibitors, systemic agents, and biologic drugs. These pending or applied-for patents underpin STRATA’s strategy to expand into new clinical indications, including vitiligo and other inflammatory and autoimmune skin conditions. “It is important that we continue to grow our market by expanding into new indications, while maximizing revenue opportunities for the Company and our partner clinics,” said Dr. Dolev Rafaeli, President and Chief Executive Officer of STRATA Skin Sciences. “Foundational to this long-term growth initiative are our proactive investments in technology development and patent filings, which are intended to provide broad intellectual property coverage around emerging combination therapy approaches.” Further, the importance of these patent fillings lies in their pioneering role in defining and protecting the combined use of Excimer laser therapy with systemic pharmacologic agents, a significant advancement in the treatment of inflammatory and autoimmune skin diseases such as psoriasis, atopic dermatitis, leukoderma, alopecia areata, and vitiligo. Excimer lasers, particularly at 308 nm, allow for precise, high-dose, localized UVB exposure, delivering therapeutic light energy to affected skin areas while sparing healthy tissue. When used alone, they provide rapid lesion clearance, but their effects may be short-lived in severe or systemic disease. These pending patents strategically address these limitations by combining phototherapy with systemic treatments—including biologic drugs and JAK inhibitors—to deliver a synergistic therapeutic effect, ranging from enhanced treatment response including prolonged remission, potential reduction of the dosage for these drugs, as well as improved safety by limiting the UV exposure to only the affected skin area. XTRAC ® Excimer Laser Insurance Coverage As previously announced, the American Medical Association’s CPT Editorial Panel, in a landmark decision, approved updates to codes 96920–96922, expanding reimbursement eligibility for XTRAC ® Excimer Laser treatments to include all inflammatory and autoimmune skin conditions—such as vitiligo, atopic dermatitis, and alopecia areata—in addition to psoriasis, effective January 1, 2027. Based on STRATA’s 2025 insurance reimbursement coverage data, more than 75% of XTRAC ® excimer laser patients treated for non-psoriasis indications are currently covered by insurance. Upcoming code expansion will result in effectively tripling the addressable patient population while improving treatment economics for both providers and the Company. PUBLICATION DETAILS Chang S, Zhang L, Liu B, et al. Efficacy of oral JAK inhibitors combined with 308-nm excimer laser in pediatric progressive vitiligo: A multicenter study. Journal of the American Academy of Dermatology. Published online March 19, 2026. doi:10.1016/j.jaad.2026.02.096 About STRATA Skin Sciences, Inc. STRATA Skin Sciences is a medical technology company dedicated to developing, commercializing, and marketing innovative products for the in-office treatment of various dermatologic conditions, such as psoriasis, vitiligo, and acne. Its products include the XTRAC ® excimer laser, VTRAC ® lamp systems, and the TheraClear ® X Acne Therapy System. STRATA is proud to offer these exciting technologies in the U.S. through its unique Partnership Program. STRATA’s popular partnership approach includes a fee per treatment cost structure versus an equipment purchase, installation and use of the device, on-site training for practice personnel, service and maintenance of the equipment, dedicated account and customer service associates, and co-op advertising support to help raise awareness and promote the program within the practice. Safe Harbor This press release includes “forward-looking statements” within the meaning of the Securities Litigation Reform Act of 1995. These statements involve known and unknown risks and uncertainties that may cause actual results to differ materially from those expressed or implied by such statements. STRATA Skin Sciences undertakes no obligation to publicly update or revise any forward-looking statements. Investor & Media Contact STRATA Skin Sciences, Inc. 5 Walnut Grove Drive, Suite 140, Horsham, PA 19044 (215) 619-3200 | ir@strataskinsciences.com | strataskinsciences.com