Delving into the Latest Updates on Porfimer Sodium with Synapse

This phase I trial evaluates the side effects of intraoperative photodynamic therapy with porfimer sodium in enhancing the response to immunotherapy with an immune checkpoint inhibitor drug in patients with non-small cell lung cancer with pleural disease. Photodynamic therapy is a technique that that works by combining a photosensitizing agent (porfimer sodium in this trial) and an intense light source to kill tumor cells. Photodynamic therapy may decrease the patients' symptoms and improve their quality of life.

Start Date10 Mar 2022

Sponsor / Collaborator

Roswell Park Comprehensive Cancer Center

NCT03678350

/ Active, not recruitingPhase 1IIT

Light Dosimetry for Intraoperative Photodynamic Therapy (IO-PDT) With Porfimer Sodium (Photofrin) in Patients With Malignant Mesothelioma or Non-Small Cell Lung Cancer (NSCLC), or Other Malignancies With Pleural Disease - Phase I Study

This phase I trial studies the side effects and how well light dosimetry system works during photodynamic therapy with porfimer sodium in treating participants with malignant mesothelioma , non-small cell lung cancer or any other malignancy with pleural disease undergoing surgery. Light dosimetry measures the amount of laser light given during photodynamic therapy. Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active when it is exposed to light. The activated drug may kill tumor cells. Using light dosimetry for intraoperative photodynamic therapy may help doctors estimate how much light is delivered during photodynamic therapy and decide if the treatment should be stopped or continued.

Start Date17 Sep 2021

Sponsor / Collaborator

Roswell Park Comprehensive Cancer Center

[+1]

NCT04753918

/ Unknown statusEarly Phase 1IIT

Single Center, Prospective, Open Label, Single-arm Clinical Study of Safety & Feasibility of Using Navigational Bronchoscopy to Perform Interstitial PD Therapy Using Lipiodol® as a Light Deliver and Photofrin® as Treatment in Subjects With Unresectable Solid Tumor in Peripheral Lung

This research study is being conducted to assess the safety and feasibility of using a newly developed bronchoscopic light delivery method of photodynamic therapy to treat subjects with solid tumors in peripheral lung, who are inoperable or refused surgery.

Start Date01 Mar 2021

Sponsor / Collaborator-

100 Clinical Results associated with Porfimer Sodium

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100 Translational Medicine associated with Porfimer Sodium

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100 Patents (Medical) associated with Porfimer Sodium

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Literatures (Medical) associated with Porfimer Sodium

27 Jan 2025·Chemistry – A European Journal

Photostimulated Anticancer Activity of Mitochondria Localized Rhenium(I) Tricarbonyl Complexes Bearing 1H‐imidazo[4,5‐f][1,10]phenanthroline Ligands Against MDA‐MB‐231 Cancer Cells

Article

Author: Paira, Priyankar ; Kar, Binoy

AbstractWe have introduced Re(I) tricarbonyl complexes (ReL1 ‐ ReL6) [Re(CO)3(N^N)Cl] where N^N=extensive π conjugated imidazo‐[4,5‐f][1,10]‐phenanthroline derivatives that helps in strong DNA intercalation, enhanced photophysical behavior, increase the 3π‐π* character of T1 state for PDT and high value of lipophilicity for cell membrane penetration. These complexes exhibited prominent intraligand/ligand‐centered (π‐π*/1LC) absorption bands at λ 260–350 nm and relatively weak metal‐to‐ligand charge‐transfer (1MLCT) bands within the λ 350–550 nm range. Among the six synthesized complexes, [(CO)3ReICl(K2‐N,N‐2‐(4‐(1‐benzyl‐1H‐tetrazol‐5‐yl)phenyl)‐1H‐imidazo[4,5‐f][1,10]phenanthroline] (ReL6) exhibited outstanding potency (IC50~6 μM, PI>9) under yellow light irradiation compared to dark conditions. Importantly, extremely lipophilic complex ReL6 showed effective penetration through the cell membrane and localized primarily in mitochondria (Pearson's correlation coefficient, PCC=0.918) of MDA‐MB‐231 cells. Complex ReL6 exhibited more than 9 times higher photo‐toxicity in normoxic and hypoxic environment of tumor by inducing 1O2 generation (type II PDT), radical generation triggered by NADH oxidation (type I PDT). This complex is a promising candidate for TNBC treatment in hypoxic tumors, with efficacy comparable to photofrin and have demonstrated CO release ability under UV light irradiation.

20 Jan 2025·ACS Applied Bio Materials

Supramolecular Organic Framework that Enables Multifunctional Doxorubicin Delivery, Photofrin Post-treatment Phototoxicity Inhibition, and Heparin Neutralization

Article

Author: Yu, Shang-Bo ; Wang, Hui ; Zong, Yang ; Li, Zhan-Ting ; Zhang, Dan-Wei ; Liu, Yue-Yang ; Lei, Zhuo ; Zhou, Wei ; Zhang, Lingyu

Although porous frameworks are structurally ideal for the development of biomaterials through drug adsorption, sequestration, and delivery, integration of multiple biofunctions into a biocompatible porous framework would greatly improve its potential for preclinical investigations by increasing both therapeutic value and research and development efficiency. Herein, we report the preparation of a highly biocompatible supramolecular organic framework from an imidazolium-derived tetrahedral monomer and cucurbit[8]uril. The supramolecular organic framework has been revealed to have regular intrinsic porosity and adsorb doxorubicin, photofrin, and heparins driven by hydrophobicity and/or ion-pairing electrostatic interactions. In vivo or in vitro assays illustrate that this adsorption leads to efficient intracellular delivery of doxorubicin, which enhances its antitumor efficacy, elimination of photofrin, which inhibits its post-treatment phototoxicity without reducing its photodynamic therapeutic activity, and sequestration of (low-molecular-weight) heparins, which neutralizes their anticoagulation activity more efficiently than clinically used protamine.

01 Nov 2024·Photochemistry and Photobiology

Comparison of red and green light for treating non‐muscle invasive bladder cancer in rats using singlet oxygen‐cleavable prodrugs with PPIX‐PDT

Article

Author: Bist, Ganesh ; Foster, Barbara A. ; Woo, Sukyung ; Kumbham, Soniya ; You, Youngjae ; Rahman, Kazi Md Mahabubur

AbstractIt has been 30 years since Photofrin‐PDT was approved for the treatment of bladder cancer in Canada. However, Photofrin‐PDT failed to gain popularity due to bladder complications. The PDT with red light and IV‐administered Photofrin could permanently damage the bladder muscle. We have been developing a new combination strategy of PpIX‐PDT with singlet oxygen‐cleavable prodrugs for NMIBC with minimal side effects, avoiding damage to the bladder muscle layer. PpIX can be excited by either green (532 nm) or red (635 nm) light. Red light could be more efficacious in vivo due to its deeper tissue penetration than green light. Since HAL preferentially produces PpIX in tumors, we hypothesized that illuminating PpIX with red light might spare the muscle layer. PpIX‐PDT was used to compare green and red laser efficacy in vitro and in vivo. The IC50 of in vitro PpIX‐PDT was 18 mW/cm2 with the red laser and 22 mW/cm2 with the green laser. The in vivo efficacy of the red laser with 50, 75, and 100 mW total dose was similar to the same dose of green laser in reducing tumor volume. Combining PpIX‐PDT with prodrugs methyl‐linked mitomycin C (Mt‐L‐MMC) and rhodamine‐linked SN‐38 (Rh‐L‐SN‐38) significantly improved efficacy (tumor volume comparison). PpIX‐PDT or PpIX‐PDT + prodrug combination did not cause muscle damage in histological analysis. Overall, a combination of PpIX‐PDT and prodrug with 635 nm laser is promising for non‐muscle invasive bladder cancer treatment.

1

News (Medical) associated with Porfimer Sodium

02 Dec 2020

·www.globenewswire.com

Photomedicine Technology Market - Growth, Trends, and Forecasts (2020 - 2025)

New York, Dec. 02, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Photomedicine Technology Market - Growth, Trends, and Forecasts (2020 - 2025)" - According to the American Society for Aesthetic Plastic Surgery (ASAPS), laser hair removal treatments were the third most popular non-surgical cosmetic procedure in 2017. According to the data published by the American Society for Aesthetic Plastic Surgery, about 31,892 laser skin resurfacing procedures and 178,488 laser or pulsed light hair removal procedures were undertaken in the United States in 2017. Furthermore Increasing awareness about non-invasive procedures, advancements in laser delivery procedures, and rising demand for cosmetic surgeries are contributing to the expanding adoption of advanced laser-based therapies, which, in turn, is expected to fuel the growth of the global photomedicine technology market during the forecast period. However, the high cost of photomedicine and advanced device technologies are expected to hinder the market growth. Key Market Trends Oncology Segment is Expected to Register Significant Growth - Phototherapy is one of the most successful therapies used for curing cancer. In a process called photodynamic therapy (PDT), light-sensitive drugs are injected into the body, which settles into the cancer cells. When the cells are exposed to certain light waves, the drugs are activated to kill the cells and shrink the tumor. - US FDA approved the photosensitizing agent called porfimer sodium, or photofrin, for use in PDT, to treat or relieve the symptoms of esophageal cancer and non-small cell lung cancer. The porfimer sodium itself can destroy the blood vessels in the tumor. When the tumor does not receive enough blood, basically, it starves to death. This is one of the successful molecules used mostly for esophageal cancer. - Aminolevulinic acid is one of the recent drugs identified to treat actinic keratosis (AK), a skin condition that can become cancer, however, it can only be used on the face or scalp. A special blue light, rather than the laser light, is used to activate this drug. - Owing to the increasing prevalence of cancer coupled with the increasing trend of early detection and therapeutic intervention, novel therapeutic approaches such as phototherapies are increasingly being employed. North America is Expected to Retain Largest Market Share During the Period of Forecast. - North America photomedicine technology market is projected to have significant market growth over the forecast period. Availability of advanced diagnostic tools and high awareness regarding these products are the key factors driving the growth of the market in North America. - For instance, in October 2018, Sun Pharma has launched ILUMYATM (tildrakizumab-asmn) in the United States for the Treatment of Moderate-to-Severe Plaque Psoriasis in adults who are candidates for systemic therapy or phototherapy. - Furthermore, increasing funding from public & private organization for R&D pertaining to the development of advanced photomedicine devices to be applied in the diagnosis of various diseases is anticipated to boost the sector growth in the near future. ? - There are several organizations and companies which are increasingly focusing on coming up with innovative technologies in the market. The Wellman Center for Photomedicine at Massachusetts General Hospital focuses on investigating the effects of light on human biology, and discovering new diagnostic and therapeutic uses of light.? This is likely to further fuel the market growth over the forecast period. Competitive Landscape Several global and local companies are operating in the market. The market is observing significant technological shifts and market participants are competing on the basis of product advancements such as increased efficacy and ease of operation. Key players in the market include Sisram Medical Ltd (Alma Lasers), Beurer GmbH, Biolitec AG, Koninklijke Philips N.V., Lumenis, Photomedex, Inc., LUMIBIRD, Candela Medical, Thor Photomedicine Ltd, and Johnson & Johnson. Reasons to Purchase this report: - The market estimate (ME) sheet in Excel format - 3 months of analyst support Read the full report: About Reportlinker ReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place. __________________________ Clare: clare@reportlinker.com US: (339)-368-6001 Intl: +1 339-368-6001

100 Deals associated with Porfimer Sodium

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KEGG	Wiki	ATC	Drug Bank
D03327	Porfimer Sodium	L01XD01	DB00707

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Barrett Esophagus	United States	Pinnacle Biologics, Inc.	08 Sep 2008
Esophageal Diseases	Canada	-	22 Oct 2006
Water-Electrolyte Imbalance	United States	Axcan Scandipharm, Inc.	01 Aug 2003
Esophageal Carcinoma	Canada	Novelion Therapeutics, Inc.	01 Jan 1993
Non-Small Cell Lung Cancer	Canada	Novelion Therapeutics, Inc.	01 Jan 1993

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Locally Advanced Lung Carcinoma	Phase 2	United States	Pinnacle Biologics, Inc.	12 Feb 2020
Small Cell Lung Cancer	Phase 2	United States	Pinnacle Biologics, Inc.	12 Feb 2020
Acinar Cell Carcinoma	Preclinical	United States	Pinnacle Biologics, Inc.	19 Apr 2013
Locally Advanced Pancreatic Adenocarcinoma	Preclinical	United States	Pinnacle Biologics, Inc.	19 Apr 2013
Pancreatic Ductal Adenocarcinoma	Preclinical	United States	Pinnacle Biologics, Inc.	19 Apr 2013
Brain Cancer	Preclinical	United States	Pinnacle Biologics, Inc.	01 Mar 2013

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Clinical Result

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Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03727061 (CTgov)	Phase 1	Recurrent Head and Neck Carcinoma	5	Quality of Life Assessment+Nivolumab+Porfimer Sodium	nicylfypyh(znxzivvzdr) = hifalusfog eglhpyeiml (tqkdotijnn, zxlyzvwhsu - gevpqdenyp) View more	-	11 Mar 2025
NCT02916745 (CTgov)	Phase 1	Secondary malignant neoplasm of lung \| Non-Small Cell Lung Cancer \| Unresectable Solid Neoplasm	5	Fiber optic+Porfimer sodium	dbfubvzxtx(rtqzlmqkvq) = aypdwruijn ldedfwwdsp (zbhaihevjh, ezuapowrlj - ojlzgtcmfq) View more	-	21 Jan 2020
NCT03344861 (CTgov)	Phase 1	Lung Cancer	10	Fiber optic+Porfimer Sodium	cumbzpicws(dshuzwjslo) = vxwaqoasbk snhtedkput (mzbghoieun, ggzcnrdpse - wbdwxlrlpt) View more	-	02 Jan 2020
NCT02068157 (CTgov)	Phase 2	Squamous cell carcinoma of the oral cavity recurrent \| Recurrent Head and Neck Carcinoma \| Squamous Cell Carcinoma of the Oropharynx \| Relapsed Squamous Cell Carcinoma of the Larynx \| Verrucous Carcinoma \| Squamous Cell Carcinoma of Head and Neck \| Squamous cell carcinoma, metastatic	3	Photodynamic Therapy+Porfimer Sodium	nxgmangtxh(uvkzhtyezn) = rgrhgyadzk lqugbuxwve (kvfhnjrtuc, padursmvrc - uazalxhaqf) View more	-	28 Aug 2017
NCT00530088 (CTgov)	Not Applicable	Dysplasia \| Carcinoma in Situ	30	Photdynamic Therapy (PDT)+porfimer sodium	(yspbtysies) = zvyrpefnwk dxeneduuhh (savjchowdb, gjpgprlnza - vzcilcpkoa) View more	-	04 Jul 2014
NCT00453336 (CTgov)	Phase 2	Gastrointestinal Diseases \| Head and Neck Neoplasms \| Precancerous Conditions	45	Photodynamic Therapy+Porfimer Sodium	ryrccqpxmo(lmvofkglmi) = syvwqxvyqy nseravvtbu (jjcltuagia, fhxnficayp - byrgmvrpoc) View more	-	18 Oct 2013
ASCO2004	Phase 2	-	100	photofrin (PF) (Debulking surgery (d-surgery))	(jrxhbbvkfb) = zumrkcaqzo tfzudkiybt (xgmtzggcyh ) View more	-	15 Jul 2004