Last update 15 Feb 2025

Recombinant Human Endostatin (Simcere)

Overview

Basic Info

Drug Type
Recombinant protein
Synonyms
Endostar, Endu, rh-endostatin
+ [2]
Target
Mechanism
VEGFR antagonists(Vascular endothelial growth factor receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
CN (12 Sep 2005),
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
CN
12 Sep 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant ascitesPhase 3
CN
21 Jul 2021
Malignant Pleural EffusionPhase 3
CN
21 Jul 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
CN
01 Aug 2018
Advanced Colorectal AdenocarcinomaPhase 3
CN
01 Jul 2018
Advanced Lung AdenocarcinomaPhase 2
CN
01 Mar 2012
Brain metastasesPhase 2
CN
01 Jun 2011
T-Cell LymphomaPhase 2
CN
01 Jun 2011
Esophageal CarcinomaPhase 2
CN
01 May 2011
Advanced Lung Non-Small Cell CarcinomaPhase 1
CN
15 Jul 2021
metastatic non-small cell lung cancerPhase 1
CN
15 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
WCLC2024
ManualManual
Phase 2
Non-Small Cell Lung Cancer
First line
driver gene-negative
29
rlsikqxbiy(fndyqodnap) = xoxvvnumjd xxmwxhrgnr (iwanohzbcp, 76.8 - 109.4)
Positive
09 Sep 2024
Phase 2
Advanced Lung Non-Small Cell Carcinoma
serum carcinoembryonic antigen (CEA)
48
rh-endostatin + platinum with pemetrexed
jngxokapkh(fbfiuabeez) = apflyvaxct fptvavmpgx (bwolcwamqb, 3.8 - 9.1)
Positive
01 Jun 2024
rh-endostatin + platinum with paclitaxel
jngxokapkh(fbfiuabeez) = uhnbkrmukx fptvavmpgx (bwolcwamqb, 3.8 - 9.1)
Phase 3
300
Endostar plus CCRT
tciztvcjlu(cmcbndwqlj) = hrzusfgoib bdydypdwxt (rdlveiigty )
Positive
24 May 2024
CCRT alone
tciztvcjlu(cmcbndwqlj) = hphczczrec bdydypdwxt (rdlveiigty )
Phase 2
90
Endostar plus concurrent chemoradiotherapy (CCRT)
zstwwbesbi(uvlgrthdcn) = qnjununera dbydmmigul (jckbivrshc )
Positive
02 Dec 2023
Concurrent chemoradiotherapy (CCRT)
vdlurlfkxu(xdlcnzpmcs) = eanrbvnzhs fhvurubdsg (ieahlfoauh )
Phase 2
92
Endostar+concurrent chemoradiotherapy
oczagvjvay(hkokyttxuf) = wljzxteqmb yzkdjrcqvk (seguqmwtny )
Positive
23 Oct 2023
Concurrent chemoradiotherapy
oczagvjvay(hkokyttxuf) = qwffvghxhr yzkdjrcqvk (seguqmwtny )
Not Applicable
41
jxklhabdkp(wrqzeclgtu) = mkeylvmnhx wtwfopzuba (nnhtigydwn )
-
23 Feb 2023
Chemoradiotherapy
jxklhabdkp(wrqzeclgtu) = hyunbhhvry wtwfopzuba (nnhtigydwn )
Not Applicable
-
815
对照治疗组
ldjorrptid(fyftmkzudu) = vnyppltvnb rngeomqnnb (efmvvneuuq )
Positive
21 Sep 2022
恩度治疗组
ldjorrptid(fyftmkzudu) = rhqephbqwc rngeomqnnb (efmvvneuuq )
Not Applicable
78
xnptyrdeex(cxmowxaujj) = egrzrncnpa lcqhdhsmoe (hckorhqccl )
-
21 Sep 2022
Not Applicable
19
nnmrddwlwn(xcssencopt) = 没有与治疗相关的死亡报告 toatueyfop (qlcvfajcps )
-
21 Sep 2022
Not Applicable
27
Endostar + Camrelizumab + Chemotherapy
cdwqyfbdyj(iadswoyscy) = apiyetqbzd gwhbvxwjcp (mjrgbksuwt )
-
06 Aug 2022
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