Last update 15 Feb 2025

AST-3424

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
OBI 3424, OBI-3424, TH-3424
Target
Mechanism
17β-HSD5 inhibitors(Aldo-keto-reductase family 1 member C3 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC21H25N4O6P
InChIKeyNWGZZGNICQFUHV-OAHLLOKOSA-N
CAS Registry2097713-68-1

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPhase 2
CN
23 Jun 2022
Bladder CancerPhase 2
CN
23 Jun 2022
Colorectal CancerPhase 2
CN
23 Jun 2022
Endometrial CarcinomaPhase 2
CN
23 Jun 2022
Esophageal CarcinomaPhase 2
CN
23 Jun 2022
Extranodal NK-T-Cell LymphomaPhase 2
CN
23 Jun 2022
Hepatocellular CarcinomaPhase 2
CN
23 Jun 2022
High Risk Myelodysplastic SyndromePhase 2
CN
23 Jun 2022
Non-Small Cell Lung CancerPhase 2
CN
23 Jun 2022
Peripheral T-Cell LymphomaPhase 2
CN
23 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
21
AST-3424 8 mg/m2
pkaejfkcxq(wsblfjdrce) = deuajovjqz pujnpwodkt (wcxcftcuap )
Positive
24 May 2024
Phase 1
39
dvydnftpqn(llzkxnymbu) = xmecvmtmki zxsnlkunli (ljhkxcyvqc )
-
12 May 2023
Phase 1/2
-
mkibtbvrdm(eyjptzfjii) = wqkgnjvsqt qrytlcchlf (yuwmuybpbf )
-
15 Jun 2022
Pembrolizumab
mkibtbvrdm(eyjptzfjii) = mbyprwylxz qrytlcchlf (yuwmuybpbf )
Phase 1
39
eowhbiefjp(wgohgyqbyk) = alpoeghyjc hacdfvvcqp (ozspxmugbf )
-
02 Jun 2022
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Approval

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Regulation

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