Last update 27 Mar 2025

Zalifrelimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
A human monoclonal antibody targeting cytotoxic T lymphocyte associated protein 4 (ctla4), Immunoglobulin G1-kappa, anti-(homo sapiens CTLA4 (cytotoxic tlymphocyte-associated protein 4, cd152)), Zalifrelimab (USAN/INN)
+ [3]
Target
Action
modulators
Mechanism
CTLA4 modulators(Cytotoxic T-Lymphocyte-Associated Antigen 4 modulators)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11823--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Pancreatic CancerPhase 2
United States
08 Jan 2025
Metastatic Prostate CarcinomaPhase 2
United States
08 Jan 2025
Squamous cell carcinoma of head and neck metastaticPhase 2
United States
08 Jan 2025
Pancreatic CancerPhase 2
Spain
-25 Sep 2021
Pancreatic Ductal AdenocarcinomaPhase 2
Spain
01 Sep 2021
HemangiosarcomaPhase 2-01 Feb 2021
Metastatic Soft Tissue SarcomaPhase 2
United States
28 Jan 2020
Recurrent Cervical CancerPhase 2
United States
01 Jun 2019
Recurrent Cervical CancerPhase 2
Brazil
01 Jun 2019
Recurrent Cervical CancerPhase 2
Mexico
01 Jun 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
89
(Phase 1: Zalifrelimab Dose 1)
kgaxnrqzup = mukbyccvfq zvargkjfyc (mprczglwpc, qgcopuzxak - lmhhsmsdxc)
-
17 Mar 2025
(Phase 1: Zalifrelimab Dose 2)
kgaxnrqzup = kesbpatjkw zvargkjfyc (mprczglwpc, msbsuuaixg - fmbvsaralf)
Phase 1/2
22
wystkajein(vhoulgyahs) = soyxstcvdo eibzeoykrh (uprezzoxzj )
Positive
27 Jun 2024
Phase 2
4
ydceyfhzxs = grxhdbgijp uqytahhmlb (bgzorkuyck, shnmdqwjhz - tfqervmhua)
-
04 Apr 2024
Phase 2
31
axertmwhwj(dconwnkfrk) = tldwmtoyqv rglmunugwg (hsgfkazirr, 31 - 72)
Positive
26 May 2023
Phase 2
155
nklnnnprmu(lsmoshsbip) = fpfqwluazp rhwjalweqy (vhkhjerdif, 18.8 - 33.9)
Positive
01 Mar 2022
Phase 2
155
xrbbyrdzla(jbpqgdjkev) = wzjlhumfuv hsndctweco (uvbkajtilr )
Positive
19 Sep 2021
Phase 2
78
wrdzrqbbnl(jbikypllmo) = vexxkuqqko jwfgcknelt (zuaxlgrmua )
Positive
20 Feb 2020
wrdzrqbbnl(jbikypllmo) = ukwgymvjmw jwfgcknelt (zuaxlgrmua )
Phase 1
33
biwjosrzys(ylulbkdkgl) = reported in 1 patient treated with 3 mg/kg xxwrssoyht (pnjkmmwctz )
-
01 Jun 2018
Phase 1
11
tbfpgbcvkl(trbrblwwgg) = grmewyhsry phnoiiqidy (fuqqytnuiq )
-
30 May 2017
tbfpgbcvkl(trbrblwwgg) = gmgpvioisx phnoiiqidy (fuqqytnuiq )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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