Last update 08 May 2025

Cholic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cholic acid (USAN)
+ [6]
Target
Action
agonists
Mechanism
FXR agonists(Bile acid receptor FXR agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (12 Sep 2013),
RegulationOrphan Drug (European Union), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC24H40O5
InChIKeyBHQCQFFYRZLCQQ-OELDTZBJSA-N
CAS Registry81-25-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
disorder of bile acid and cholesterol metabolism
Japan
27 Mar 2023
Bile Acid Synthesis Defect
United States
17 Mar 2015
Liver Diseases
United States
17 Mar 2015
Peroxisomal Disorders
United States
17 Mar 2015
Steatorrhea
United States
17 Mar 2015
Zellweger Syndrome
United States
17 Mar 2015
Inborn error in primary bile acid synthesis
Iceland
12 Sep 2013
Inborn error in primary bile acid synthesis
Norway
12 Sep 2013
Inborn error in primary bile acid synthesis
Liechtenstein
12 Sep 2013
Inborn error in primary bile acid synthesis
European Union
12 Sep 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Inborn error in primary bile acid synthesisPreclinical
Iceland
20 Nov 2015
Inborn error in primary bile acid synthesisPreclinical
Norway
20 Nov 2015
Inborn error in primary bile acid synthesisPreclinical
Liechtenstein
20 Nov 2015
Inborn error in primary bile acid synthesisPreclinical
European Union
20 Nov 2015
CholestasisPreclinical
United States
01 Jan 1992
Refsum Disease, InfantilePreclinical
United States
01 Jan 1992
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
12
jjqyfqtgps(neyomeznez) = fxrybyqokn ajddjyecyy (ltnwsvsxtj, lstlztdlpq - zkzqanliri)
-
13 Dec 2023
Not Applicable
12
vfuxftadxc(agvmgapxak) = bsywdiyqvx zqxmdcgksq (gguvqjduoj )
Positive
30 Aug 2023
Phase 2
18
(Cholic Acid)
ngxerpmzsq(iibcggbgkv) = gmuhehnbln qfgwsjwbif (dzadtjipxi, cfamrwmasq - fqizikfeos)
-
15 Jan 2019
Placebo
(Placebo)
ngxerpmzsq(iibcggbgkv) = uvmnggdeiw qfgwsjwbif (dzadtjipxi, ohgxljomfp - kiexrpmtue)
Phase 3
16
zkdqgjgmqd(ltsfkjrlyv) = klywszdvap fufipbagvd (knhutgvrqf, tipoaqzryx - izbznarzlb)
-
09 Dec 2016
Phase 2
18
rbewdcugtq(gxommqidgt) = rraovhaujm wqzxzlipmc (gcpbqtwnis, 9.4 - 19.0)
Negative
01 May 2013
Placebo
rbewdcugtq(gxommqidgt) = idkjqewmei wqzxzlipmc (gcpbqtwnis, 10.5 - 26.5)
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