Last update 31 May 2025

Fanregratinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HMPL-453
Action
antagonists
Mechanism
FGFR1 antagonists(Fibroblast growth factor receptor 1 antagonists), FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists), FGFR3 antagonists(Fibroblast growth factor receptor 3 antagonists)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC27H33ClN6O2
InChIKeyLVQABCJAWBLTAO-HDICACEKSA-N
CAS Registry1628537-44-9

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant Solid NeoplasmPhase 2
China
22 Jan 2022
Gastroesophageal junction adenocarcinomaPhase 2
China
17 Jan 2022
Intrahepatic CholangiocarcinomaPhase 2
China
03 Sep 2020
FGFR2 positive Intrahepatic CholangiocarcinomaPhase 2
China
26 Aug 2020
Malignant Pleural MesotheliomaPhase 2
China
10 Jan 2020
Mesothelioma, MalignantPhase 2
China
30 Dec 2019
Advanced Malignant Solid NeoplasmPhase 1
Australia
01 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Advanced biliary tract cancer
Second line
FGFR2 Fusion
25
(150 mg (QD, cohort 1))
snqtphqoxm(yvgkecqeaj) = ffrefrguiy lpzkcmnuiw (dflegfmhhi, 2.6 - NR)
Positive
31 May 2023
(300 mg (QD, 2w on/1w off, cohort 2))
rxrcbuzlji(yejtomlfpo) = ixcfgkiwgp jmvigqimgs (fxifgylmli, 18.7 - 81.3)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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