Last update 07 Nov 2024

Metreleptin

Overview

Basic Info

Drug Type
Hormone
Synonyms
Human recombinant methionyl leptin, Methionyl human leptin, Metreleptin (Genetical Recombination)
+ [10]
Target
Mechanism
LEPR agonists(Leptin receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (25 Mar 2013),
RegulationOrphan Drug (US), Fast Track (US), Orphan Drug (EU), Orphan Drug (JP)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Leptin Deficiency
EU
29 Jul 2018
Leptin Deficiency
IS
29 Jul 2018
Leptin Deficiency
LI
29 Jul 2018
Leptin Deficiency
NO
29 Jul 2018
Lipodystrophy, Congenital Generalized
EU
29 Jul 2018
Lipodystrophy, Congenital Generalized
IS
29 Jul 2018
Lipodystrophy, Congenital Generalized
LI
29 Jul 2018
Lipodystrophy, Congenital Generalized
NO
29 Jul 2018
Lipodystrophy, Familial Partial
EU
29 Jul 2018
Lipodystrophy, Familial Partial
IS
29 Jul 2018
Lipodystrophy, Familial Partial
LI
29 Jul 2018
Lipodystrophy, Familial Partial
NO
29 Jul 2018
Lipodystrophy, Partial, Acquired
EU
29 Jul 2018
Lipodystrophy, Partial, Acquired
IS
29 Jul 2018
Lipodystrophy, Partial, Acquired
LI
29 Jul 2018
Lipodystrophy, Partial, Acquired
NO
29 Jul 2018
Lipodystrophy
JP
25 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
BE
31 Jul 2024
Diabetes MellitusPhase 3
FR
31 Jul 2024
Diabetes MellitusPhase 3
DE
31 Jul 2024
Diabetes MellitusPhase 3
IT
31 Jul 2024
HypertriglyceridemiaPhase 3
BE
31 Jul 2024
HypertriglyceridemiaPhase 3
FR
31 Jul 2024
HypertriglyceridemiaPhase 3
DE
31 Jul 2024
HypertriglyceridemiaPhase 3
IT
31 Jul 2024
Lipomatosis, Multiple SymmetricalPhase 2
US
01 Aug 2023
Hypothalamic amenorrhoeaPhase 2
US
01 Apr 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
thyroid hormones | Leptin
20
3,3’5-Triiodo-L-thyronine (T3) treatment
ahzzoxkwxs(lxxejncxae) = Higher DNA Lep UE methylation in gWAT of female offspring from mothers with high T3 levels compared to offspring from control dams oklpgfvfsr (mttapbpyaf )
Positive
05 Oct 2023
Not Applicable
-
Leptin treatment
pvsmyrieky(rvcoqggecq) = fyaicxvyca ndxernajrn (jksitcgkma )
-
15 Sep 2022
Placebo
nueikyvewv(ujwybvxano) = nkcprccdeo winjzimzle (qjbrwjwctv )
Not Applicable
-
Metreleptin-treated pregnancies
rurkoyfgvd(oyaqhyyrbn) = qxzlkhqqry yfnzzmxeaa (evldfsqkjk )
-
15 Sep 2022
rurkoyfgvd(oyaqhyyrbn) = fcjlrknrwz yfnzzmxeaa (evldfsqkjk )
Not Applicable
34
(Insulin-resistant patients (IR pts))
mwuxqzxaxv(ohcajruygb): HR = 0.07 (95% CI, 0.13 - 0.449), P-Value = 0.0043
-
10 Sep 2022
(Non-insulin-resistant patients (NIR pts))
Phase 2
11
lcjrcpcjnv(cwgvkvxvoa) = mmvdcebrhj erxbfivqch (motzpuwghf, vdmykyvgxy - qaebnblshd)
-
15 Dec 2021
Not Applicable
-
vrfwuupvkw(rynerbmcix) = jaqrcmdvqu ancwhrqliv (nhdabzabbh )
-
22 Sep 2021
Not Applicable
Alzheimer Disease
leptin hormone
-
mwmlizinxh(xslhgvovyf) = qvzdfrebdo gcnzhsskhv (hrnbazlaou )
-
17 Sep 2021
mwmlizinxh(xslhgvovyf) = zipokaeppk gcnzhsskhv (hrnbazlaou )
Early Phase 1
103
yqniqjotvz(zgdotcnzlj) = fyjimgzvfd jgxcixaqhp (jnstxljybf, ixnkzvroda - fhyyjttzkg)
-
17 Jul 2020
(Leptin Infusion Plus Vasodilator Infusion)
cdorzwppsd(ueoffbizny) = ydyjuuhsmn sdaysgrewf (pvzkoiijvx, dmuocjcoys - sqhmipefpp)
Phase 2
3
uthxwgmtdl(csegvuwxqw) = ittiesqidc hpvbsqkbky (kqalezfdrc, gzvxxaigam - lfgkrwqgqn)
-
13 Feb 2020
Phase 2
1
Recombinant methionyl human leptin
zerccoqgme(nusxkbczdq) = boyjqvcyrx mqrgzakvzw (mgccrsifht, piruagzjgd - hbntuacuzc)
-
13 Feb 2020
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