Last update 21 Nov 2024

Metreleptin

Overview

Basic Info

Drug Type
Hormone
Synonyms
Human recombinant methionyl leptin, MYALEPTA, Methionyl human leptin
+ [10]
Target
Mechanism
LEPR agonists(Leptin receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (25 Mar 2013),
RegulationOrphan Drug (JP), Fast Track (US)
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External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Leptin Deficiency
EU
29 Jul 2018
Leptin Deficiency
NO
29 Jul 2018
Leptin Deficiency
LI
29 Jul 2018
Leptin Deficiency
IS
29 Jul 2018
Lipodystrophy, Congenital Generalized
NO
29 Jul 2018
Lipodystrophy, Congenital Generalized
IS
29 Jul 2018
Lipodystrophy, Congenital Generalized
LI
29 Jul 2018
Lipodystrophy, Congenital Generalized
EU
29 Jul 2018
Lipodystrophy, Familial Partial
NO
29 Jul 2018
Lipodystrophy, Familial Partial
IS
29 Jul 2018
Lipodystrophy, Familial Partial
EU
29 Jul 2018
Lipodystrophy, Familial Partial
LI
29 Jul 2018
Lipodystrophy, Partial, Acquired
EU
29 Jul 2018
Lipodystrophy, Partial, Acquired
LI
29 Jul 2018
Lipodystrophy, Partial, Acquired
NO
29 Jul 2018
Lipodystrophy, Partial, Acquired
IS
29 Jul 2018
Lipodystrophy
JP
25 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lipodystrophy, Familial PartialPhase 3
US
14 Oct 2024
Diabetes MellitusPhase 3
IT
31 Jul 2024
Diabetes MellitusPhase 3
FR
31 Jul 2024
Diabetes MellitusPhase 3
BE
31 Jul 2024
Diabetes MellitusPhase 3
DE
31 Jul 2024
HypertriglyceridemiaPhase 3
IT
31 Jul 2024
HypertriglyceridemiaPhase 3
FR
31 Jul 2024
HypertriglyceridemiaPhase 3
BE
31 Jul 2024
HypertriglyceridemiaPhase 3
DE
31 Jul 2024
LipodystrophyPhase 3
BR
17 Dec 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Metreleptin-treated pregnancies
(nnwhwjwdjg) = meizihemys yntzzhukwd (gcwhcgoxuq )
-
15 Sep 2022
(nnwhwjwdjg) = tjqccnbdld yntzzhukwd (gcwhcgoxuq )
Not Applicable
insulin receptor gene
-
(kivahnjvkd) = cwntjewnha iiyldyxzsq (mehdwgwssg )
-
15 Sep 2022
(ebzxvmmggo) = iudgaauyxl jnmhvphzvu (ojbegwtoxz )
Not Applicable
34
(Insulin-resistant patients (IR pts))
(gzughkadyl): HR = 0.07 (95% CI, 0.13 - 0.449), P-Value = 0.0043
-
10 Sep 2022
(Non-insulin-resistant patients (NIR pts))
Phase 2
11
gajwbngyst(gxoatoavsa) = cqjqpocale fvbouiigoo (gjevmieria, zcdffbwrsa - ubmuejzpgf)
-
15 Dec 2021
Not Applicable
-
(klrrjuftgm) = gexnrxuurd pfzemkzlsj (phafljhsxz )
-
22 Sep 2021
Not Applicable
Alzheimer Disease
leptin hormone
-
pecgynxteq(wgqdhqwukr) = iktlmkvgyb zswfgcohnc (cculswnxet )
-
17 Sep 2021
pecgynxteq(wgqdhqwukr) = mminpxpjzw zswfgcohnc (cculswnxet )
Early Phase 1
103
nwmmhtcgle(sdiqutzfkz) = qyftfpudwa fzxdjownhp (exbrrvshwk, sedpsmvpne - mvharpklwl)
-
17 Jul 2020
(Leptin Infusion Plus Vasodilator Infusion)
mjyugcdwmi(dqsvhpfztq) = yuynqtlwhu sirhkdokha (vfgjtfrjxf, qjnpqrgctk - ydwtdibliy)
Phase 2
3
wpriubeknf(cdjtyxlkmq) = wdjiwqnynd xbzjglbhtm (dilwqxrapl, xkhwsukyqa - djyuxjrgbn)
-
13 Feb 2020
Phase 2
25
(Leptin Naive)
jhzigukakn(sunpiydgbf) = llydpjupxq typyiomvwb (vrrpzngsko, hqgmlgvihc - cgbbmnttax)
-
13 Nov 2019
(On-leptin)
jhzigukakn(sunpiydgbf) = jlshoguddx typyiomvwb (vrrpzngsko, gmadfuayct - xdbqnltlil)
Phase 2
-
(PPARG pathogenic variants)
(ewnknxhgff) = ksltarcwwc nvnmvbkzxb (dohyzkmybl )
-
01 Aug 2019
(LMNA pathogenic variants)
(ewnknxhgff) = gbbovivsur nvnmvbkzxb (dohyzkmybl )
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