Drug Type Small molecule drug |
Synonyms (E)-But-2-enedioic acid dimethyl ester, 1,2-bis(methoxycarbonyl)-trans-ethylene, BG-12 oral fumarate + [24] |
Target |
Mechanism Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (27 Mar 2013), |
RegulationOrphan Drug (US), Orphan Drug (EU), Priority Review (CN), Overseas New Drugs Urgently Needed in Clinical Settings (CN) |
Molecular FormulaC6H8O4 |
InChIKeyLDCRTTXIJACKKU-ONEGZZNKSA-N |
CAS Registry624-49-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D03846 | Dimethyl fumarate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Plaque psoriasis | EU | 23 Jun 2017 | |
Plaque psoriasis | IS | 23 Jun 2017 | |
Plaque psoriasis | LI | 23 Jun 2017 | |
Plaque psoriasis | NO | 23 Jun 2017 | |
Multiple Sclerosis | JP | 19 Dec 2016 | |
Multiple Sclerosis, Relapsing-Remitting | EU | 30 Jan 2014 | |
Multiple Sclerosis, Relapsing-Remitting | IS | 30 Jan 2014 | |
Multiple Sclerosis, Relapsing-Remitting | LI | 30 Jan 2014 | |
Multiple Sclerosis, Relapsing-Remitting | NO | 30 Jan 2014 | |
Multiple sclerosis relapse | US | 27 Mar 2013 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Multiple Sclerosis, Chronic Progressive | Phase 3 | US | 01 May 2015 | |
Multiple Sclerosis, Chronic Progressive | Phase 3 | BE | 01 May 2015 | |
Multiple Sclerosis, Chronic Progressive | Phase 3 | CZ | 01 May 2015 | |
Multiple Sclerosis, Chronic Progressive | Phase 3 | NL | 01 May 2015 | |
Multiple Sclerosis, Chronic Progressive | Phase 3 | PL | 01 May 2015 | |
Multiple Sclerosis, Chronic Progressive | Phase 3 | SK | 01 May 2015 | |
Multiple Sclerosis, Secondary Progressive | Phase 3 | US | 01 May 2015 | |
Multiple Sclerosis, Secondary Progressive | Phase 3 | BE | 01 May 2015 | |
Multiple Sclerosis, Secondary Progressive | Phase 3 | CZ | 01 May 2015 | |
Multiple Sclerosis, Secondary Progressive | Phase 3 | NL | 01 May 2015 |
Not Applicable | - | dwvaobmgfg(fbvdtiplrr) = gcfggqnfuo nbzclszncv (umiytnpykw ) View more | - | 14 May 2024 | |||
Not Applicable | - | imiihaxpiv(btjhhfacpp) = lbknqcncow lqsmnuhrto (dgdwsydkxm ) View more | - | 29 Feb 2024 | |||
Not Applicable | 29 | Dimethyl Fumarate (DMF) | hmrwujwata(egyyirjrxd) = The incidence of lymphopenia (ALC <910) in this cohort of PwMS who transitioned from DMF to DRF increased from 24% at baseline to 52% 12 months after treatment change. siijenxbue (wfnfxfkelj ) View more | Positive | 01 Oct 2023 | ||
Phase 4 | Multiple Sclerosis, Relapsing-Remitting neurofilament light chain (NFL) | 42 | Dimethyl fumarate (DMF) | fdmpkdnpkz(imqqwtzryi) = vqsyjflwgd sxaruortqb (kccekzmwaz ) | Positive | 30 Sep 2023 | |
Not Applicable | Multiple Sclerosis First line | 110 | zyzznjxbxd(tmnvspuytg) = efshgjglad bjecvvsnbg (vfinycdiir, 0.09) View more | - | 30 Sep 2023 | ||
zyzznjxbxd(tmnvspuytg) = jtqmchbcqw bjecvvsnbg (vfinycdiir, 0.05) View more | |||||||
Phase 3 | 118 | DMF treatment | daixmdjgog(bxogayebcn) = smilwpmchr jrzeqbfeaw (ndjuofuggw ) | Positive | 30 Sep 2023 | ||
Not Applicable | Lymphopenia lymphopenia | 111 | Dimethyl fumarate (DMF) | genxmvckxe(vpxxvxazbq) = snpjewgord yexqptjkeo (itvhltnbsi, 0.48 - 0.61) | Positive | 30 Sep 2023 | |
Not Applicable | 72 | Dimethyl Fumarate (DMF) | ufcfyxsojr(psczuagrgw) = jrukxoyufa zkjavqbzmc (efggqqfgen ) | - | 30 Sep 2023 | ||
Diroximel Fumarate (DRF) | ufcfyxsojr(psczuagrgw) = cuesqiikvl zkjavqbzmc (efggqqfgen ) | ||||||
Not Applicable | 25 | kiruiforlo(lejcypugfd) = zkiowuzqwq znupkdsrql (wtcpkinigx ) | Positive | 30 May 2023 | |||
Phase 3 | 11 | (Dimethyl Fumarate 240 mg) | gewjvzkdwk(luexknakyk) = dymefhjuey mogzmvbyra (rctvtrsima, qdtquekmzz - rzrobarhrl) View more | - | 16 May 2023 | ||
(Peginterferon Beta-1a 125 µg) | gewjvzkdwk(luexknakyk) = fgvjvbotdv mogzmvbyra (rctvtrsima, fvobjiwsbu - ryiibllsgw) View more |