Last update 06 Dec 2024

Zotiraciclib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Zotiraciclib (USAN), Zotiraciclib Citrate, SB-1317
+ [4]
Mechanism
CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), CDK5 inhibitors(Cyclin-dependent kinase 5 inhibitors), CDK7 gene inhibitors(Cyclin-dependent kinase 7 gene inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC29H32N4O8
InChIKeyNWYDRHSNEATNRI-SQQVDAMQSA-N
CAS Registry1204918-73-9

External Link

KEGGWikiATCDrug Bank
D11599Zotiraciclib--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Malignant GliomaPhase 2
US
16 May 2023
GlioblastomaPhase 2
US
14 Dec 2016
GliosarcomaPhase 2
US
14 Dec 2016
High grade gliomaPhase 2--
Recurrent GliomaPhase 1
CN
24 Apr 2019
Advanced Hepatocellular CarcinomaPhase 1-01 Dec 2018
Chronic Lymphocytic LeukemiaPhase 1
US
01 Sep 2012
Small Lymphocytic LymphomaPhase 1
US
01 Sep 2012
Acute Lymphoblastic LeukemiaPhase 1
US
01 Aug 2010
Acute Myeloid LeukemiaPhase 1
US
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Zotiraciclib + radiotherapy
rcmcdwqkiz(abognezuch) = Main toxicities of zotiraciclib were neutropenia, gastrointestinal disorders and hepatotoxicity shayufwrfb (uydqhrnhdl )
-
28 Jun 2024
Not Applicable
-
lelvnbdzcj(txnelttipr) = Main toxicities of zotiraciclib were gastrointestinal disorders cugglgfdys (ylnvlsrzud )
-
24 May 2024
Phase 1
71
Radiation Therapy+Zotiraciclib
gwdvkbqeow(usryzmkcsg) = qgnxscclwc ievepscecd (kmqsnaniuj )
Negative
26 May 2023
gwdvkbqeow(usryzmkcsg) = lzqetxhxel ievepscecd (kmqsnaniuj )
Phase 1
53
lvgasafyay(zbgdcsipha) = mbxulictpy ecaehqucez (pcysvevvrj )
Positive
15 Jun 2021
Phase 1
-
begbklhcnr(jcwzudrgmo) = vxfkdzqbtg bchpabkrqe (yzbodfrovd )
-
01 Oct 2014
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Clinical Trial

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Approval

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Regulation

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