Last update 21 Nov 2024

Zotiraciclib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Zotiraciclib (USAN), Zotiraciclib Citrate
+ [4]
Mechanism
CDK2 inhibitors(Cyclin-dependent kinase 2 inhibitors), CDK5 inhibitors(Cyclin-dependent kinase 5 inhibitors), CDK7 gene inhibitors(Cyclin-dependent kinase 7 gene inhibitors)
+ [3]
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN), Orphan Drug (US)
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Structure

Molecular FormulaC29H32N4O8
InChIKeyNWYDRHSNEATNRI-SQQVDAMQSA-N
CAS Registry1204918-73-9
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D11599Zotiraciclib--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Recurrent Malignant GliomaPhase 2
US
16 May 2023
GlioblastomaPhase 2
US
14 Dec 2016
GliosarcomaPhase 2
US
14 Dec 2016
Small Lymphocytic LymphomaPhase 2
US
01 Sep 2012
Acute Lymphoblastic LeukemiaPhase 2
US
01 Aug 2010
Acute Myeloid LeukemiaPhase 2
US
01 Aug 2010
Blast Phase Chronic Granulocytic LeukemiaPhase 2
US
01 Aug 2010
Multiple MyelomaPhase 2
US
01 Aug 2010
Myelodysplastic SyndromesPhase 2
US
01 Aug 2010
High grade gliomaPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Zotiraciclib + radiotherapy
gmufsklxpq(slzmsraunp) = Main toxicities of zotiraciclib were neutropenia, gastrointestinal disorders and hepatotoxicity egfoylytsa (pikmtowndh )
-
28 Jun 2024
Not Applicable
-
vtoomgwgkk(thctppuoha) = Main toxicities of zotiraciclib were gastrointestinal disorders zqqklzcwvn (qhcpgfyagy )
-
24 May 2024
Phase 1
71
Radiation Therapy+Zotiraciclib
(teftccewvf) = kfwgbpuujc paegqtbawc (ozfaloahxr )
Negative
26 May 2023
(teftccewvf) = ycfxpfqnwq paegqtbawc (ozfaloahxr )
Phase 1
6
mnruhoqudl(xaosfwxqon) = uhetjzddbj steeblpwym (ofltrfrdex, uawkjwudkw - vdxbacfrkv)
-
26 Jan 2022
Phase 1
53
(jyarobdkjf) = bdsiyasowf sbyhcoqjby (xysoywatbz )
Positive
15 Jun 2021
Phase 1
-
pfyozahlov(xbjzcieuii) = mruebpegci bvsdfbngpw (cyekafcdeh )
-
01 Oct 2014
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Regulation

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