Delving into the Latest Updates on Ibuprofen Piconol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ibuprofen piconol (JP17/USAN), イブプロフェンピコノール, ピメプロフェン

+ [6]

Target

COX-1 x COX-2

Mechanism

COX-1 inhibitors(Cyclooxygenase-1 inhibitors), COX-2 inhibitors(Cyclooxygenase-2 inhibitors)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesCongenital Disorders+ [1]

Active Indication

Acne VulgarisAcute eczemaChronic eczema+ [5]

Inactive Indication-

Originator Organization

Torii Pharmaceutical Co., Ltd.

Active Organization

Hisamitsu Pharmaceutical Co., Inc.

Torii Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

JP (17 Mar 1984),

Acute eczemaChronic eczemaDermatitis, Atopic+ [4]

Regulation-

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Structure

Molecular FormulaC19H23NO2

InChIKeyACEWLPOYLGNNHV-UHFFFAOYSA-N

CAS Registry64622-45-3

本试验为正式试验，旨在研究局部涂抹汕头经济特区鮀滨制药厂研制、生产的布洛芬吡甲酯乳膏（T：10 g﹕0.5 g）的药代动力学特征；以鳥居薬品株式会社生产的布洛芬吡甲酯乳膏（STADERM®，R：10 g﹕0.5 g）为参比制剂，评价受试制剂与参比制剂在布洛芬/布洛芬吡甲酯上的药动学参数（Cmax、AUC0-t、AUC0-∞）的差异性，并评价受试制剂的安全性。

[Translation]

This test is a formal test, aiming to study the pharmacokinetic characteristics of topical application of ibuprofen methylpyridin cream (T: 10 g﹕0.5 g) developed and produced by Tuobin Pharmaceutical Factory in Shantou Special Economic Zone; Ibuprofen methylpyridine cream (STADERM®, R: 10 g﹕0.5 g) produced by Co., Ltd. is a reference preparation. The test preparation and the reference preparation are evaluated on ibuprofen/ibuprofen methylpyridine. Differences in pharmacokinetic parameters (Cmax, AUC0-t, AUC0-∞), and evaluate the safety of the test preparations.

Start Date-

Sponsor / Collaborator

Shandong Bestcomm Pharmaceutical Co., Ltd.

CTR20182207 / Not yet recruiting

布洛芬吡甲酯软膏单中心、随机、开放、单剂量、平行试验设计人体药代动力学比较研究

[Translation] Comparative study on the pharmacokinetics of ibuprofen methylpyrifos ointment in humans using a single-center, randomized, open-label, single-dose, parallel trial design

本试验为正式试验，旨在研究局部涂抹汕头经济特区鮀滨制药厂研制、生产的布洛芬吡甲酯软膏（T：10 g﹕0.5 g）的药代动力学特征；以鳥居薬品株式会社生产的布洛芬吡甲酯软膏（STADERM®，R：10 g﹕0.5 g）为参比制剂，评价受试制剂与参比制剂在布洛芬/布洛芬吡甲酯上的药动学参数（Cmax、AUC0-t、AUC0-∞）的差异性，并评价受试制剂的安全性。

[Translation]

This test is a formal test, aiming to study the pharmacokinetic characteristics of topical application of ibuprofen methyl methyl ointment (T: 10 g: 0.5 g) developed and produced by Tuobin Pharmaceutical Factory in Shantou Special Economic Zone; Torii Ointment Co., Ltd. Ibuprofen methylpyridine ointment (STADERM®, R: 10 g﹕0.5 g) produced by the company is a reference preparation. The pharmacodynamics of the test preparation and the reference preparation on ibuprofen/ibuprofen methylpyridine are evaluated. The differences in chemical parameters (Cmax, AUC0-t, AUC0-∞) were evaluated, and the safety of the test preparations was evaluated.

Start Date-

Sponsor / Collaborator

Shandong Bestcomm Pharmaceutical Co., Ltd.

100 Clinical Results associated with Ibuprofen Piconol

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100 Translational Medicine associated with Ibuprofen Piconol

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100 Patents (Medical) associated with Ibuprofen Piconol

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3

Literatures (Medical) associated with Ibuprofen Piconol

01 Jan 1996·Experimental AnimalsQ4 · MEDICINE

Spontaneous Comedones on the Skin of Hairless Descendants of Mexican Hairless Dogs.

Q4 · MEDICINE

Article

Author: DOI, Kunio ; KIMURA, Tohru

In the first experiment, the skin sebum and humidity, perspiration ability of sweat glands, and histology of spontaneous comedones were examined in hairless descendants of Mexican hairless dogs. The skin of females showed lower humidity than that of males. Some animals with a large number of comedones exhibited remarkably high skin sebum scores. The comedones were distributed throughout the dorsal skin, and a cluster of lesions was found mainly in the limbs and prepuces. The sweat glands showed no perspiration in the sudorific test. Histologically, both infant and adult animals had lesions of micro- and/or "blackhead" comedones. Plugged follicles containing abundant keratic substances associated well-developed sebaceous glands. Spontaneous comedones in the skin of hairless dogs were grossly and histologically similar to the acne vulgaris observed in human beings. The skin of some adult animals showed a large number of protrusive comedones which were solid cystic structures containing organized substances. In the second experiment, three kinds of antiacne agents (sulfur and camphor, sulfur and resorcinol, and ibuprofen piconol) were applied daily to the test sites for one month. These antiacne agents caused prominent extrusion of keratin plugs from follicular sites. The results suggest that the hairless dogs are a predictive model for evaluating the efficacy of antiacne agents proposed for acne treatment.

01 Jan 1991·Journal of Pharmaceutical SciencesQ3 · MEDICINE

Ibuprofen Piconol Hydrolysis In Vitro in Plasma, Whole Blood, and Serum Using Different Anticoagulants

Q3 · MEDICINE

Article

Author: Dennis Stalker ; J. Mark Christensen

Hydrolysis kinetics of ibuprofen piconol to ibuprofen were determined in vitro in plasma, whole blood, and serum. Varying initial concentrations of ibuprofen piconol with different anticoagulants (EDTA, heparin, citrate, or no anticoagulant) were used in determining the effects each had on the rate of ibuprofen piconol hydrolysis. Varying the initial concentration of ibuprofen piconol did not alter the hydrolysis half-life (concentration range from 50 to 200 micrograms/mL). The anticoagulant used altered the hydrolysis half-life. For plasma, the half-life was shortest when no anticoagulant was present (t 1/2 = 2.5 h) and longer with the presence of anticoagulants; for citrate, t 1/2 = 8.0 h, for heparin; t 1/2 = 15.5 h; and for EDTA, t 1/2 = 161.8 h. Red blood cell uptake of ibuprofen piconol was minimal and ranged from 0.4 to 4.1% over the ibuprofen piconol concentrations used in the study.

01 Mar 1988·Contact DermatitisQ2 · MEDICINE

Contact dermatitis from ibuprofen piconol

Q2 · MEDICINE

Article

Author: Motoi Oguchi ; Tamiyo Akaeda ; Kinue Shirai ; Keiko Kubo

100 Deals associated with Ibuprofen Piconol

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External Link

KEGG	Wiki	ATC	Drug Bank
D01122	-	M02AA13 R02AX02 M01AE01 G02CC01 C01EB16	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Acne Vulgaris	JP	Torii Pharmaceutical Co., Ltd.	13 Feb 1986
Acute eczema	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Chronic eczema	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Dermatitis, Atopic	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Dermatitis, Contact	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Dermatitis, Perioral	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Herpes Zoster	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984
Rosacea-like dermatitis	JP	Torii Pharmaceutical Co., Ltd.	17 Mar 1984