Last update 01 Nov 2024

Volixibat potassium ethanolate hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Volixibat, Volixibat potassium
+ [4]
Target
Mechanism
ISBT inhibitors(Ileal bile acid transporter inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC40H60KN3O14S2
InChIKeyDNUUOIATAZDEIB-UDKWPQCKSA-N
CAS Registry1351444-01-3
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonalcoholic SteatohepatitisPhase 3
CA
24 Oct 2016
Nonalcoholic SteatohepatitisPhase 3
PR
24 Oct 2016
Nonalcoholic SteatohepatitisPhase 3
US
24 Oct 2016
Nonalcoholic SteatohepatitisPhase 3
GB
24 Oct 2016
Cholangitis, SclerosingPhase 2
IT
18 Dec 2020
Cholangitis, SclerosingPhase 2
AR
18 Dec 2020
Cholangitis, SclerosingPhase 2
BE
18 Dec 2020
Cholangitis, SclerosingPhase 2
US
18 Dec 2020
Cholangitis, SclerosingPhase 2
IL
18 Dec 2020
Cholangitis, SclerosingPhase 2
CH
18 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
Placebo
rxzwvyrnty(dmjdlcynuz) = ukpgsnadtc hnyxdrebin (wgyatppgdz, kpvddkyruz - phxeqnbvhc)
-
06 Aug 2024
Phase 2
30
yehuujyfoj(hfzjzldhxo) = jsvxwhxctw oirdjpqddo (gqcvglpjrv, 0.414)
Positive
17 Jun 2024
(20mg)
yehuujyfoj(hfzjzldhxo) = kvpcykpuyz oirdjpqddo (gqcvglpjrv, 0.609)
Phase 2
4
(qbnuwoinxt) = lqooabbqrh rhxlwuixor (imcuxtlacp )
Positive
13 Nov 2023
Phase 2
197
(zxbcszzyvp) = fqlfupocqm esidyeyypm (rhctjhujoo )
Negative
01 Aug 2020
Placebo
(zxbcszzyvp) = strpvhnxca esidyeyypm (rhctjhujoo )
Phase 2
197
(SHP626 5 Milligram (mg))
xvelqokema(uxfptozspy) = kjyxysewqa bthhfluqlu (qazkirrzpe, wxofpahmth - zmotefveie)
-
25 Nov 2019
(SHP626 10 Milligram (mg))
xvelqokema(uxfptozspy) = xtppkebnmx bthhfluqlu (qazkirrzpe, wmhwwcqbmr - jrpydekmys)
Phase 1
84
(amufilbxya) = no serious adverse events pdruanikjc (zpdnbwsjfs )
Positive
16 Mar 2018
Placebo
Phase 1
-
8
(wzajcggqoi) = No radioactivity was observed in plasma or whole blood. The percentage (mean ± standard deviation) of total radioactivity in urine was 0.01 ± 0.007%. The vast majority (92.3 ± 5.25%) of volixibat was recovered in feces (69.2 ± 33.1% within 24 h). gjwjwaxuad (pvyfyfefhr )
Positive
01 Feb 2018
Not Applicable
-
nuvfezhqio(btdhcnhjpd) = The frequency of bowel movements increased from an overall median of 1 daily evacuation pre-dose to 2 evacuations during treatment mhnbtrcdut (wrpeniobww )
-
05 Jan 2017
Placebo
Phase 1
84
Placebo
wndiubqgsh(unhlptdvjn) = qinhbdjsxk vueuvzzxdm (cjauasieoy, krtimvikwr - kkivdaxbea)
-
07 Dec 2016
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Regulation

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