Last update 27 Feb 2026

SAN-300

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Anti-VLA-1 antibody, Anti-VLA-1 mAb, SAN 300
+ [1]
Target
α1β1
Action
antagonists
Mechanism
α1β1 antagonists(Integrin alpha1/beta1 antagonists)
Therapeutic Areas
Immune System DiseasesSkin and Musculoskeletal Diseases
Active Indication
Rheumatoid Arthritis
Inactive Indication-
Originator Organization
Biogen, Inc.Biogen, Inc.
Active Organization
Biogen, Inc.Biogen, Inc.
Inactive Organization
Bausch Health Americas, Inc.Salix Pharmaceuticals, Inc.Salix Pharmaceuticals, Inc.
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with SAN-300
NCT02047604
/ CompletedPhase 2
A Randomized, Double-blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of Escalating Doses of SAN-300 in Patients With Active Rheumatoid Arthritis With Inadequate Response to Disease-Modifying Anti-rheumatic Drug(s).
ACTRN12611000123943
/ CompletedPhase 1
A phase 1 study of healthy subjects and patients with rheumatoid arthritis receiving single doses of SAN-300 or placebo to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SAN-300
100 Clinical Results associated with SAN-300
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100 Translational Medicine associated with SAN-300
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100 Patents (Medical) associated with SAN-300
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100 Deals associated with SAN-300
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Rheumatoid ArthritisPhase 2
United States
Bausch Health Americas, Inc.
01 Dec 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT02047604 (C2013-0302, CTgov)
Phase 2
Rheumatoid Arthritis
41
(Cohort A - SAN-300 0.5 mg/kg QW)
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-
21 Jun 2021
(Cohort B - SAN-300 1.0 mg/kg QW)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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