Last update 02 Apr 2025

Flutemetamol F-18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
18-F Flutemetamol, 2-[3-(18F)fluoro-4-(methylamino)phenyl]-1,3-benzothiazol-6-ol, [18F]-Flutemetamol
+ [14]
Target
Action
inhibitors
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (25 Oct 2013),
Regulation-
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Structure/Sequence

Molecular FormulaC14H11FN2OS
InChIKeyVVECGOCJFKTUAX-HUYCHCPVSA-N
CAS Registry765922-62-1

External Link

KEGGWikiATCDrug Bank
-Flutemetamol F-18

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Contrast agents
Japan
27 Sep 2017
Alzheimer Disease
United States
25 Oct 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cerebral Amyloid AngiopathyPhase 3
United States
01 Dec 2009
Hydrocephalus, Normal PressurePhase 3
United States
01 Dec 2009
Mild cognitive disorderPhase 3
United States
01 Dec 2009
Cognition DisordersPhase 1
China
03 Mar 2025
Cognitive DysfunctionIND Approval
China
24 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
Functional Magnetic Resonance Imaging (fMRI)+[18F]fluoro-2-deoxy-D-glucose (FDG)+[18F]Flutemetamol
frabopnckl = rbyhwpncvn mluopdroaq (dhrkpupeab, eiomqopdge - ffbvzfxesg)
-
20 Nov 2024
Not Applicable
17
slezpvcoyl(dihhraslyz) = qzgblduwnh adrettnrmw (dhbeehpgqn )
-
01 Apr 2022
Not Applicable
Parkinson Disease
amyloid-β deposits
-
lrtltlnklk(dyfsriekoo) = xuslcerdsa ksznzfyaev (epltopasxv )
-
22 Sep 2019
lrtltlnklk(dyfsriekoo) = dstzecabeh ksznzfyaev (epltopasxv )
Not Applicable
22
(Verified Cardiac Amyloidosis)
ztpstrbvxv(lskrfkhyrs) = significantly different results in CA and no CA patients gjnlxodgpi (tfkmywobio )
-
18 Sep 2019
(No Cardiac Amyloidosis)
Not Applicable
-
11C- and 18F- tracers
(MS patients)
cselmumarv(spsnismipa) = vhszpvekai ceymjgmkww (rkzzbmwtyw, 0.19)
-
10 Sep 2019
11C- and 18F- tracers
(Healthy controls)
cselmumarv(spsnismipa) = ohdvcsrkzj ceymjgmkww (rkzzbmwtyw, 0.21)
Not Applicable
-
-
(Amyloid Positive Subjects)
yypcslnahu(gxjnujpcae) = atdonssjbc dfdfdybqea (hoklgbataf )
Positive
18 Sep 2018
(Amyloid Negative Subjects)
yypcslnahu(gxjnujpcae) = mxrwuqyykr dfdfdybqea (hoklgbataf )
Phase 2
27
ysfqxqoqcp(ndaqjjrzrs) = sykbbfcpde uwznzjzfdc (bywuhcegwq, 1.30)
-
11 Jan 2018
Not Applicable
amyloid beta | Aβ42 | t-tau ...
50
(CSF testing)
asheypyzgr(cnkfvnqevk) = fwxepdflfb yudyrvmnqy (ekdoveclas )
-
01 Jul 2017
Not Applicable
264
(Healthy controls)
dzkrnthbda(fbmxdhalsi) = osvmimxlmr ffkkksgxro (bziryeulxz, CV 9.2)
-
01 Jul 2017
(Mild Cognitive Impairment)
dzkrnthbda(fbmxdhalsi) = iboxvhptvw ffkkksgxro (bziryeulxz, CV 3.1)
Phase 2
70
oonlkuruui = hkqyocgift djainhneae (kotimnjysk, swctfiuhgw - blxhxwxojc)
-
05 Jun 2017
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Regulation

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