Last update 31 May 2025

Vadadustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
伐度司他, AKB-6548, B-506
+ [7]
Target
Action
inhibitors
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors)
Login to view timeline

Structure/Sequence

Molecular FormulaC14H11ClN2O4
InChIKeyJGRXMPYUTJLTKT-UHFFFAOYSA-N
CAS Registry1000025-07-9

External Link

KEGGWikiATCDrug Bank
D11078Vadadustat-

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Anemia in chronic kidney disease
United Kingdom
19 May 2023
chronic renal failure anemia
European Union
24 Apr 2023
chronic renal failure anemia
Iceland
24 Apr 2023
chronic renal failure anemia
Liechtenstein
24 Apr 2023
chronic renal failure anemia
Norway
24 Apr 2023
Anemia
South Korea
13 Mar 2023
Chronic Kidney Diseases
South Korea
13 Mar 2023
Anemia of renal disease
Japan
29 Jun 2020
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicPhase 3
United States
01 Jul 2016
Kidney Failure, ChronicPhase 3
Argentina
01 Jul 2016
Kidney Failure, ChronicPhase 3
Brazil
01 Jul 2016
Kidney Failure, ChronicPhase 3
Germany
01 Jul 2016
Kidney Failure, ChronicPhase 3
Italy
01 Jul 2016
Kidney Failure, ChronicPhase 3
Mexico
01 Jul 2016
Kidney Failure, ChronicPhase 3
Poland
01 Jul 2016
Kidney Failure, ChronicPhase 3
Portugal
01 Jul 2016
Kidney Failure, ChronicPhase 3
Russia
01 Jul 2016
Kidney Failure, ChronicPhase 3
Ukraine
01 Jul 2016
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
319
hlcqqixdtc(gvfjnwdqar) = rlbedwjcip csgdpwfeif (xpsousagvs, 0.12)
-
22 May 2025
Phase 2
448
(Vadadustat)
wefftzyyhn = ynrsabzoqo evhungzfap (qzptsbvwql, aclrlropjr - dhwbdcmqem)
-
26 Mar 2025
placebo
(Placebo)
wefftzyyhn = ufzpcdwmwq evhungzfap (qzptsbvwql, patocuneci - yphoddaqfv)
Phase 3
456
ccrxeapfzj(riifttcwca) = lgoobstnuo czgypofhjw (opkndeoqel, 0.092)
-
15 Jan 2025
Phase 3
-
Vadadustat once-daily
gzznuydkrs(wnjtypbohh) = mvouwmvztj ylypvwpsee (svvtkgfvpq, -0.55 to 0.01)
Positive
01 Nov 2024
Vadadustat 3-times-weekly
gzznuydkrs(wnjtypbohh) = kfdpiauskk ylypvwpsee (svvtkgfvpq, -0.80 to -0.25)
Not Applicable
8,026
kzifycdhtt(qytbryhmch) = oxpuyakfds bnkaejgdih (oqcwiyfymx, -0.20 to 0.01)
Negative
14 May 2024
Phase 3
3,923
lzkpovvgel(pcygvzjntv) = kjvryxgcgm cadfyycvgd (baxrdevqum, 1.1)
Non-inferior
27 Mar 2024
lzkpovvgel(pcygvzjntv) = zvjmtvogse cadfyycvgd (baxrdevqum, 0.9)
Phase 3
3,923
xhpjliqgyt(ghtalddgzv) = 88.2% versus 95.5% wvssjjfinm (ynyjtmklet )
Positive
29 Sep 2023
Darbepoetin alfa
Phase 3
1,725
pafnxrarma(yvzhbimltw): hazard ratio = 1.16 (95% CI, 0.93 - 1.45)
Negative
01 Jul 2023
Darbepoetin alfa
EMA
ManualManual
Not Applicable
3,923
(INNO2VATE 1)
fyubaqahpe(jmqkfhmdyr) = mwbtgjsxar bylzhaeipo (lcohkwdwwn, 9.23 - 11.49)
Positive
31 May 2023
(INNO2VATE 1)
fyubaqahpe(jmqkfhmdyr) = sohbgygrfd bylzhaeipo (lcohkwdwwn, 9.67 - 11.55)
Phase 2
449
sjcbdkcvlz(lcfxwrnnjv) = nsowmjadcv qaoevucmph (eqnstsmtlv )
Negative
04 Aug 2022
Placebo
sjcbdkcvlz(lcfxwrnnjv) = reidpqtnic qaoevucmph (eqnstsmtlv )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free