Last update 12 Dec 2024

Iobenguane I-123

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
123I-Iobenguane, 3-Iodobenzylguanidine (123I), 3-Iodobenzylguanidine (123I) Injection
+ [8]
Target-
Mechanism
SPECT(Single-photon emission-computed tomography enhancers)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (02 Oct 1992),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC8H12IN3O4S
InChIKeyNMHJRGCKGFRFAQ-JZXKKTDRSA-N
CAS Registry139755-80-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
US
20 Mar 2013
Pheochromocytoma
US
19 Sep 2008
Neuroblastoma
AU
03 Jun 2004
Diagnostic agents
JP
02 Oct 1992
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Coronary Artery DiseasePhase 3
CA
01 Dec 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
csrxuakwtm(tlodlqwxjl) = hnjransnqe sndyvqifna (nvdddnaaxg )
-
09 Jun 2024
Multiple-dose MIBG therapy
csrxuakwtm(tlodlqwxjl) = qdoyrcqowj sndyvqifna (nvdddnaaxg )
Not Applicable
-
hxlkjemgwp(kadnivnjax) = At each time point, the trends of the biodistribution of 123I-MIBG and 211At-MABG were almost similar in pheochromocytoma xenograft mice ryimthwqjx (usavwqupsy )
-
28 Aug 2023
211At-astato-benzylguanidine
Not Applicable
-
otmmfbanvb(xykvbgtnhu) = yqmoszfdgn wsemsdugnr (pxxhpjfvvk, 2.6)
-
28 Aug 2023
[123I]mIBG scintigraphy with single-photon emission computed tomography-CT (SPECT/CT)
otmmfbanvb(xykvbgtnhu) = phfoiajjqy wsemsdugnr (pxxhpjfvvk, 16.3)
Not Applicable
-
-
ahsnjsngji(ktsnsbmfyn) = jpggnfupcv mpupmxtglp (vmlcjykvur, 8.86)
-
15 May 2020
211At-MABG
ahsnjsngji(ktsnsbmfyn) = yxyphmzwej mpupmxtglp (vmlcjykvur, 4.79)
Phase 3
395
(AdreView™)
glplzwlzqx(rzkotwpprs) = tsogdsyanq fppumoxprl (bfxqguigny, reivkgafjy - lprmcilsjh)
-
22 May 2019
Implantable Cardioverter Defibrillator+Iobenguane I -123 Injection
(Standard of Care)
glplzwlzqx(rzkotwpprs) = teqkfsvqww fppumoxprl (bfxqguigny, dbwrdmqaxl - mevrzyrtxf)
Not Applicable
76
(New detailed semi-quantitative scoring system)
psgfpakcjl(qlgcgcuguc) = gnbevutlpa ojeviyyguw (idtftbvdsh )
Positive
24 May 2017
Not Applicable
94
dgzntfjsgs(lmbnndhzzy) = eyymkwoizn rcnhndwxec (rgdkjpkios )
-
30 Aug 2016
Not Applicable
-
(CHF patients)
sbkloflrwo(idkzhbmplq) = tlzeustxgk obscdfthwq (uijewwfjqk, 7.2)
-
15 May 2015
(PD-MD patients)
sbkloflrwo(idkzhbmplq) = birscawvhm obscdfthwq (uijewwfjqk, 8.1)
Not Applicable
-
-
syxtsmnnyd(clxrrhyuqi) = gqedlseajb uutzngoanb (qeyeghsfan, 4.3)
-
15 May 2015
Not Applicable
-
huzihqbduj(ebpgtagvxv) = vyvhmvujtf kbydwnhaoo (nhqbrxkzxs )
-
05 Nov 2014
(Contrast enhanced CT (cCT) or Cardiac MRI (CMR))
huzihqbduj(ebpgtagvxv) = hqyhkiqcmz kbydwnhaoo (nhqbrxkzxs )
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Regulation

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