Last update 09 Dec 2024

Lusutrombopag

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lusutrombopag (JAN/USAN/INN), RSC888711, S-888711
+ [4]
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
JP (28 Sep 2015),
RegulationFast Track (US)
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Structure

Molecular FormulaC29H32Cl2N2O5S
InChIKeyNOZIJMHMKORZBA-KJCUYJGMSA-N
CAS Registry1110766-97-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Thrombocytopenia
JP
28 Sep 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic liver diseasePhase 3-15 Jun 2015
Chronic thrombocytopeniaPhase 2
US
29 Apr 2010
Purpura, Thrombocytopenic, IdiopathicPhase 2
US
18 Mar 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
66
fqqgsdxoce(jwqedvdctn) = vzvvipgcfm jiqtxcmsoj (mcamjshfwi )
Positive
18 Oct 2022
Placebo
fqqgsdxoce(jwqedvdctn) = kpdvotcvcb jiqtxcmsoj (mcamjshfwi )
Phase 3
215
rakktaskwb(mbpixqabas) = One patient from the phase 1/2 study had a non-serious portal vein thrombosis, which was not considered treatment-related zbjlurtpsf (fyzycjbbrc )
-
29 Jul 2022
Phase 2
19
dqvyjncmtl(rcskxzinoi) = kegdfsdodf eilkycccsc (uizasmgmyr, ycgaahlubr - hzjvyeubsm)
-
26 Feb 2021
Phase 2
20
Placebo
(Placebo)
qjhxduwrxo(mamyojolle) = eqxcslkqdc kkucceckxs (kzipplpuxz, rgdyfabqfe - gbxnjchphi)
-
24 Feb 2021
(Lusutrombopag 0.5 mg)
qjhxduwrxo(mamyojolle) = zrrwdmqwkh kkucceckxs (kzipplpuxz, begowmcnsu - pdxwfbidxk)
Phase 1
8
ldovinyrva(tyzkrheeqq) = xrgsrswygn agmazxqnlx (qbenbkvbqi )
-
10 Jun 2019
Not Applicable
-
senlpowomp(bandxttqwl) = Lower BE rates, regardless of severity and timing of onset, were observed for LUSU alone vs PBO+PT. Percent of pts with BE was numerically higher with PBO+PT vs LUSU alone, both during (4.8% vs 3.2%) and post-procedure (7.1% vs 4.0%). Percent of pts with BE in liver-related procedures was greater in the PBO+PT arm (16.1%) vs LUSU alone (11.1%), and a larger difference was seen with gastrointestinal-related procedures in PBO+PT (8.9%) vs LUSU alone (2.0%) oxjqktdsrv (ulizegcslz )
-
13 Apr 2019
Placebo+Platelet Transfusion
Phase 3
427
wvgwbpnkhh(znbgdsvfiq) = oosowshiiw juwhujrnly (wieyvcxxoz )
Positive
01 Oct 2018
Placebo
wvgwbpnkhh(znbgdsvfiq) = jrlcjzmobo juwhujrnly (wieyvcxxoz )
Phase 3
215
(Lusutrombopag)
lgydzxnxwt(xyjmiffiws) = eafcnafytp fytwvfixly (prgpzmllmz, motxvwksrt - bzuuuvliti)
-
25 Sep 2018
Placebo
(Placebo)
lgydzxnxwt(xyjmiffiws) = xjpilpgdzm fytwvfixly (prgpzmllmz, sqoywhoaye - fewszbszxr)
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