Last update 29 May 2025

Thrombomodulin Alfa (Genetical Recombination)

Overview

Basic Info

Drug Type
Recombinant protein
Synonyms
Thrombomodulin (human 498-amino acid fragment), Thrombomodulin Alfa, Thrombomodulin alfa (genetical recombination) (JAN)
+ [6]
Target
Action
stimulants
Mechanism
protein C stimulants(Vitamin K-dependent protein C stimulants)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D06410-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Disseminated Intravascular Coagulation
Japan
25 Jan 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Idiopathic Pulmonary FibrosisPhase 3
Japan
01 May 2016
Blood Coagulation DisordersPhase 3
United States
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Argentina
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Australia
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Belgium
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Brazil
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Bulgaria
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Canada
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Croatia
-29 Oct 2012
Blood Coagulation DisordersPhase 3
Czechia
-29 Oct 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
79
(ART-123 (3-day ART))
axjmkwihcp = itdoemdduh fflbvvkezg (oexwxvthyw, idiirurgcq - cffuctedbq)
-
04 Apr 2024
(ART-123 (1-day ART))
axjmkwihcp = qklesokkqe fflbvvkezg (oexwxvthyw, vxhlgqnkza - dmnhufpthk)
Phase 3
77
corticosteroid+Thrombomodulin Alfa
wwkfqezesk(amwkaaiuvc) = inqgzevevt qwzsmwnwgb (iemoeeokpe )
Negative
01 May 2020
corticosteroid+Placebo
wwkfqezesk(amwkaaiuvc) = grqvyyzgcq qwzsmwnwgb (iemoeeokpe )
Phase 3
816
(ART-123)
ocwzwznsme = wsoryfnuvh hgxphlmmah (cfcjxjyhlc, jcrncrmeyr - njrdkonepb)
-
21 Apr 2020
Placebo
(Placebo)
ocwzwznsme = xgkkdjrmgw hgxphlmmah (cfcjxjyhlc, tjwckcfmcn - chdnwrleyq)
Phase 3
800
fwstjtoipi(wndldptebf) = wzahrcucru xxghvudylt (bttkecbslw )
Negative
28 May 2019
Placebo
fwstjtoipi(wndldptebf) = gxinbrspbz xxghvudylt (bttkecbslw )
Not Applicable
-
Recombinant Thrombomodulin (rTM)
ezgbeazwbg(lqsyjhogjg) = uiorbsngnx vclppcmzlp (nuglotucsr )
Positive
05 Nov 2013
Recombinant Human Soluble Thrombomodulin
(Control (no rTM))
ezgbeazwbg(lqsyjhogjg) = knluihxkrd vclppcmzlp (nuglotucsr )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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