Drug Type CRISPR/Cas9 |
Synonyms Nex-z |
Target |
Mechanism TTR inhibitors(Transthyretin inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (US) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Transthyretin Amyloid Cardiomyopathy | Phase 3 | SE | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | DE | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | DK | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | ES | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | CA | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | TW | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | AU | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | AU | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | TW | 13 Dec 2023 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | SG | 13 Dec 2023 |
NCT04601051 (Literature) Manual | Phase 1 | 36 | (felzpxcopy) = bcgqpmsbxy bzmfgdaoyp (gheprtcikc, -33 to 49) View more | Positive | 16 Nov 2024 | ||
NCT04601051 (Biospace) Manual | Phase 1 | 62 | (gcjlingapv) = The most commonly reported adverse events were infusion-related reactions, which occurred in 38% of patients. The majority of adverse events, including infusion-related reactions, were Grade 1 or 2 in severity, transient and resolved spontaneously. Other adverse events that were reported in greater than 10% of patients included headache, diarrhea and back pain, and were all Grade 1 or 2. pgfnjfeqbf (jmpuyfqqnx ) View more | Positive | 02 Nov 2023 | ||
Phase 1 | 14 | wobpbfzadp(xpwsnninko) = Mild and transient infusion reactions were the most common adverse event with NTLA-2001 mtndtdbeqh (glnvwdnkil ) | Positive | 24 Jun 2022 | |||
Phase 1 | 6 | (0.1 mg / kg) | (jvsfbjuvmq) = uklkfcaupt ptoxbputum (klcdugmusg ) | Positive | 05 Aug 2021 | ||
(0.3 mg / kg) | (jvsfbjuvmq) = wjotidplix ptoxbputum (klcdugmusg ) |