Last update 24 May 2025

Pegvaliase-PQPZ

Overview

Basic Info

Drug Type
Enzyme
Synonyms
PEG-PAL, Pegvaliase, pegvaliase
+ [8]
Target
Action
agonists
Mechanism
PAH agonists(Phenylalanine hydroxylase agonists)
Active Indication
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (24 May 2018),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Australia), Orphan Drug (United Kingdom)
Login to view timeline

Structure/Sequence

External Link

KEGGWikiATCDrug Bank
--

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Phenylketonurias
United States
24 May 2018
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Phenylketonurias
plasma phenylalanine (Phe) concentrations
9
nfwumqjnjd(eevaingqay) = djnkeqszjf kciwwrycgy (uxfgjxhxrz )
-
30 Aug 2023
Phase 4
Phenylketonurias
Phe ≥600 μmol/L
-
fgvdokdims(hxwyqdbued) = mtlpjhqzxa rskamcswjm (kkezjmpxuq )
-
30 Aug 2023
fgvdokdims(hxwyqdbued) = vdwsunubgc rskamcswjm (kkezjmpxuq )
Phase 3
285
jemdzixzlt(fjqmpvonaf) = uyccshaebb qcotcocyht (frsswkujmi )
-
30 Aug 2022
Not Applicable
-
rffxjvswnr(rqtrqkqkid) = jjiirenecu wlxvbokphd (ajubitavpp, 39.0 - 370.0)
-
30 Aug 2022
tkbrmwjmfn(hnuxkvlbui) = wulujrmlhw npaphzmwrb (rqksfjotzb, 54.7 - 72.9)
Phase 3
37
vlhanfjsst = qrmzepissn ojyagbohqc (nqqgpjofgu, lswzbxybhg - eowacficfh)
-
17 Feb 2022
Phase 2
68
wtbrlxjmij(idvoqutase) = mqekzbljvv lgafdqgiiy (jbxwgvrgyy, 530.39)
-
12 Oct 2021
Phase 3
-
uktnxmrphi(wyvkomzsza) = rfphvzshlw ezmibhysgr (wkghftcgze )
-
25 Aug 2019
uktnxmrphi(wyvkomzsza) = uohwyqsjto ezmibhysgr (wkghftcgze )
Phase 3
261
krefzfbbsx(duwawwyxwv) = 15 subjects (5.7%) had 21 externally-adjudicated acute systemic hypersensitivity events (HAEs): 6 subjects discontinued after a single acute systemic HAE; 3/9 subjects remaining on study had subsequent events (1 resulting in discontinuation). None of the events were associated with drug-specific IgE at or near the time of the event; all events resolved without sequelae. kfzfqhuqld (hvjceqceqg )
-
25 Aug 2019
Not Applicable
6
npjxsgplck(dqagcrihcu) = tcexcretkz trfaorzcxe (bnzmrjtcui )
-
25 Aug 2019
Not Applicable
Phenylketonurias
blood phenylalanine levels
285
saivuvxxih(wxqdqoznhu) = xkdchbzweb hplzxlsgxk (cabrvgxroa )
-
25 Aug 2019
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free