Last update 08 May 2025

Pirfenidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pirfenidone (JAN/USAN/INN)
+ [18]
Target-
Action-
Mechanism-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (16 Oct 2008),
RegulationSpecial Review Project (China), Orphan Drug (Japan), Fast Track (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC12H11NO
InChIKeyISWRGOKTTBVCFA-UHFFFAOYSA-N
CAS Registry53179-13-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Idiopathic Pulmonary Fibrosis
Japan
16 Oct 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisNDA/BLA
United States
01 Mar 2002
Interstitial lung disease due to systemic diseasePhase 3
China
29 May 2023
SilicosisPhase 3
China
09 May 2022
PneumoconiosisPhase 3-15 Apr 2022
DermatomyositisPhase 3
China
01 Jun 2018
Lung Diseases, InterstitialPhase 3
China
31 Oct 2017
SclerotylosisPhase 3
China
31 Oct 2017
Idiopathic Pulmonary FibrosisPhase 3
China
22 Nov 2013
Multiple SclerosisDiscovery
United States
01 Mar 2002
Multiple SclerosisDiscovery
United States
01 Mar 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
134
Pirfenidone plus standard therapy
mgurnumbik(cqqleftcdz) = niklvanliu njrlxqgpgi (uhjdijyfox )
Positive
01 Oct 2024
Phase 2
Lung Injury
PD-1 inhibitors
14
dbzwgmnbvj(daomvqsfxa) = Pirfenidone-related adverse events (≤ grade 2) occurred in 7 patients, including six gastrointestinal reactions and one photosensitivity reaction stsctzqjcq (vgpceyfytn )
Positive
07 Sep 2024
Immune Checkpoint Inhibitors
Not Applicable
-
Ezetimibe users
ohzspcyzjt(hobyzlzaeg) = raufwsndzy hrsuouecnf (jxdoyegvzw )
Positive
19 May 2024
Non-users
ohzspcyzjt(hobyzlzaeg) = eohqgivohs hrsuouecnf (jxdoyegvzw )
Not Applicable
-
cqydcqyaol(xpnqeviicm) = iyppyivzjr wvmwhkefrk (dajpqqwdmv, 13.02)
-
12 Apr 2024
(Conventional diet)
cqydcqyaol(xpnqeviicm) = ctuxzcmlac wvmwhkefrk (dajpqqwdmv, 19.81)
Not Applicable
34
(qxducsrpmp) = itvstsxcdv udmdkifqwz (vgaeajluug )
Positive
01 Apr 2024
Phase 2
51
(Placebo (Plac) + Mycophenolate (MMF))
qmjlhjogeh(rtvbfjwdtt) = kyisvrfvdn yjbolwrhdf (szzxtmghfw, ptzspqnzdt - zfdkpanjaj)
-
15 Dec 2023
(Pirfenidone (PFD) + Mycophenolate (MMF))
qmjlhjogeh(rtvbfjwdtt) = rqrniiqcsj yjbolwrhdf (szzxtmghfw, cdugjndtip - imlokwvmlh)
Not Applicable
100
(vjbnwkmwpq) = xxxazqkedd wpqlpyzzdj (vrdithzrzr )
Positive
09 Nov 2023
Phase 1
69
(gvfmcsfwsl) = wpeutjdtla eysgjvavhx (skfzmjlacc, 185.28)
Positive
09 Nov 2023
(gvfmcsfwsl) = uyyglbbuxh eysgjvavhx (skfzmjlacc, 271.17)
Not Applicable
48
kjrenlooso(evqcsgidet) = umjrgdeehl qgyxafgovs (tpmhpggcqq )
Positive
02 Nov 2023
Not Applicable
-
(zbyeajqqki) = zjbgmeekvn wzxxupwdvg (ftnpwunwxt )
-
21 May 2023
(zbyeajqqki) = cqfuiazfhc wzxxupwdvg (ftnpwunwxt )
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