AKT1 gene inhibitors(Serine/threonine-protein kinase AKT gene inhibitors), Akt-2 inhibitors(Serine/threonine-protein kinase AKT2 inhibitors), EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists)

Therapeutic Areas

NeoplasmsInfectious DiseasesDigestive System Disorders

Active Indication

Helicobacter pylori infectionMycobacterium InfectionsColorectal Cancer

Inactive Indication-

Originator Organization-

Active Organization

Universidade Estadual Paulista Júlio De Mesquita Filho Unesp

Mokpo National University

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC21H22O4

InChIKeyWBDNTJSRHDSPSR-KPKJPENVSA-N

CAS Registry144506-14-9

100 Clinical Results associated with Licochalcone C

100 Translational Medicine associated with Licochalcone C

100 Patents (Medical) associated with Licochalcone C

262

Literatures (Medical) associated with Licochalcone C

01 Jun 2025·Addictive Behaviors Reports

Unpacking the complexities in racial and ethnic discrimination and tobacco use and cannabis co-use behaviors among young adults in the U.S.

Article

Author: Lee, Eugenia ; Sterling, Kymberle L ; Fryer, Craig S ; Pike Moore, Stephanie

IntroductionThere is a general paucity of research describing the relationship between racial and ethnic discrimination (RED) and coping strategies on use of little filtered cigars and cigarillos (LCCs) across racial and ethnic identities. This research sought to unravel some of the complex, multilayered experiences of RED and subsequent coping strategies to examine the impact on LCC use.MethodsData come from a cross-sectional survey conducted among a nationally representative sample of U.S. young adults (n = 1,178) in May 2022. Respondents were asked about their exposure to LCC marketing (systemic RED), interpersonal experiences of RED, coping strategies, and use of LCCs as-sold (tobacco only) or as a blunt (with marijuana). Multivariable logistic regression was used to examine odds of LCC use examining systemic and interpersonal RED and the relationship between emotion-focused and problem-focused coping strategies among those who have experienced RED.ResultsExposure to systemic RED was associated with increased odds of blunt use. Interpersonal experiences of RED were associated with increased odds of LCC use as-sold and as blunts. Among those who experienced any RED, the impact of problem-focused and emotion-focused coping was differential across racial and ethnic identities in the impact on LCC use modality.ConclusionSystemic and interpersonal RED are independently associated with LCC use. There are considerable differences in how young adults cope with RED which necessitates additional research to further elucidate the complex pathways between RED and product use to more effectively inform strategies to address the undeniable racial and ethnic inequities in tobacco-related health outcomes.

01 Mar 2025·Global Change Biology

Three Decades of Land Cover Changes Shifted Environment‐Driven Greening Towards Browning in Coastal China

Article

Author: Huang, Yuanyuan ; Zhu, Zaichun ; Piao, Shilong ; Liang, Yige ; Sun, Yan

ABSTRACTCoastal vegetation serves as a protective buffer against the deleterious impacts of storm surges, influencing the dynamic exchange of energy and matter and mediating the lateral transport of carbon from land to the ocean. Comprehensive understanding of coastal vegetation dynamics is crucial for sustaining the ecological and biogeochemical functions of coastal ecosystems. Despite the considerable influence of land cover change (LCC) on vegetation greenness, quantifying this impact along the rapidly developing Chinese coasts amid significant social and economic changes over the past decades remains inadequately addressed. In this study, using moderate‐resolution Landsat‐based Normalized Difference Vegetation Index (NDVI), we found that LCC generally reduced the vegetation greenness and shifted the environment‐driven greening towards browning in coastal China over the past three decades. Compared to ‘Stable Land Cover areas’, ‘Land Cover Change areas’ exhibited a 23% decrease in greening proportion and a 39% increase in browning proportion. Urbanization occurring in coastal regions during 1992–2018 dominated the browning effect over 29% of ‘LCC areas’, which outweighed the greening effect of climate change, CO2 fertilization, and nitrogen enrichment. This negative effect of urbanization on coastal vegetation was scarcely compensated by afforestation, despite the concurrent implementation of the National Coastal Shelterbelt System Construction Project (NCSSCP). The coastal afforestation area under the green scenario (SSP1‐2.6) during 2030–2060 is projected to be substantially higher than that of the past 30 years. It is expected to mitigate the negative effect of LCC on coastal vegetation greenness and enhance coastal ecosystem sustainability through ecological conservation policies, particularly forest restoration in the coastal zone of China. Furthermore, the insights derived from satellite observations in this study will serve as fundamental information for representing the coastal vegetation in the next generation of Earth system models (ESMs), enhancing the predictions related to future coastal ecosystem function and adaptation.

01 Jan 2025·Pediatrics & Neonatology

Impact of late-onset circulatory collapse and bronchopulmonary dysplasia on short-term outcomes in preterm infants: A Japanese retrospective cohort study

Article

Author: Kawada, Kohei ; Kosaka, Yukako ; Ishida, Shuji ; Nakanishi, Hidehiko ; Sekiya, Rika ; Yamaguchi, Ayano ; Ooka, Mari

BACKGROUNDLate-onset circulatory collapse (LCC) and bronchopulmonary dysplasia (BPD) are significant complications in extremely preterm infants, leading to adverse short-term outcomes. While adverse short-term outcomes associated with each condition have been reported individually, the impact of the interaction between BPD and LCC on adverse short-term outcomes remains unclear.METHODSThis was a retrospective multicenter cohort study based on the Neonatal Research Network of Japan (NRNJ) including extremely preterm infants weighing <1500 g who were admitted to the neonatal intensive care unit and registered with NRNJ between 2010 and 2022. Demographic characteristics, morbidity, and mortality were compared among the BPD-LCC-, BPD-LCC+, BPD + LCC-, and BPD + LCC + groups.RESULTSA total of 14,644 infants were included. LCC was an independent risk factor for BPD (adjusted odds ratio (aOR) 1.30, 95% confidence interval (CI): 1.17-1.46) and significantly increased the risk of more severe BPD forms (aOR 1.34, 95%CI 1.22-1.46). Concomitant LCC in infants with BPD did not affect the incidence of home oxygen therapy and tracheostomy. Furthermore, LCC was found to increase the incidence of periventricular leukomalacia (PVL) (aOR 2.33, 95%CI 1.70-3.18). However, PVL was not associated with BPD. BPD was associated with an increased risk of severe retinopathy of prematurity (ROP) (aOR 1.14, 95% CI 1.02-1.26), which was further increased with concomitant LCC (aOR 1.97, 95% CI 1.71-2.26).CONCLUSIONSLCC was a risk factor for the development of BPD. Concurrent LCC in infants with BPD increased the risk of severe ROP. Furthermore, LCC increased the incidence of PVL. However, PVL was not associated with BPD. The possible interaction between LCC and BPD was rooted in steroid deficiency. These findings suggest a potential avenue for future preventive interventions.

100 Deals associated with Licochalcone C

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Helicobacter pylori infection	Preclinical	Brazil	Universidade Estadual Paulista Júlio De Mesquita Filho Unesp	14 May 2024
Mycobacterium Infections	Preclinical	Brazil	Universidade Estadual Paulista Júlio De Mesquita Filho Unesp	14 May 2024
Colorectal Cancer	Preclinical	South Korea	Mokpo National University	01 Jan 2024

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