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Digestive System Disorders

Neoplasms

Infectious Diseases

Small molecule drug

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A glimpse into the focused therapeutic areas

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Disease Domain	Count

Neoplasms	1
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

Akt-1 x Akt-2 x EGFR	1

High sodium intake causes hypertension. Various efforts for reducing salt consumption are proceeding all over the world. Solar salt contains reduced sodium and abundant mineral, such as calcium, potassium, and magnesium, comparing to ordinary salt. Use of solar salt, instead of ordinary salt, may have beneficial effects to blood pressure.
The investigators are going to conduct a preliminary study that can support antihypertensive effect of solar salt intake.

Start Date-

Sponsor / Collaborator

Chung-Ang University Hosptial

[+1]

KCT0009655

/ CompletedNot ApplicableIIT

Effects of Virtual reality simulation prior to clinical placement as means to practice nursing diagnosis: multi-center RCT

Start Date18 Oct 2023

Sponsor / Collaborator

Mokpo National University

100 Clinical Results associated with Mokpo National University

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0 Patents (Medical) associated with Mokpo National University

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4,111

Literatures (Medical) associated with Mokpo National University

01 Jul 2025·Brain, Behavior, and Immunity

L-tyrosine alleviates autism-like behavior in mice by remodeling the gut microbiota

Article

Author: Lao, Yujie ; Guo, Jingya ; Tong, Tao ; Fang, Jingjing ; Huang, Kunlun ; Kang, Seong-Gook

Autism spectrum disorder (ASD) is characterized by impaired social interaction and repetitive stereotyped behavior, and effective interventions for the core autistic symptoms are currently limited. This study examines the protective role of L-tyrosine in alleviating ASD-like behavioral disorders in a valproic acid (VPA)-induced ASD mouse model and explores the underlying mechanisms via integrated multi-omics. We first investigated the potential of dietary L-tyrosine in mitigating autistic behavior. Subsequently, 16S rRNA sequencing, hippocampal transcriptomics, and neurotransmitter metabolome were employed to elucidate the underlying mechanism. Further, we conducted transplantation of the L-tyrosine-regulated microbiota in VPA-induced ASD mice. The results showed that L-tyrosine supplementation significantly mitigates ASD-like behavioral disorders, alleviates social communication deficits, and reduces repetitive behavior in autistic mice. L-tyrosine also attenuates the neuronal loss caused by VPA treatment in the DG and CA1 hippocampal regions in mice. The hippocampi of the L-tyrosine-treated mouse model for ASD displays modified gene expression profiles and different neurotransmitter levels. L-tyrosine also mitigates colonic barrier damage and amends the gut microbial composition and function. The integrative transcriptomic, metabolomic, and microbiome analysis shows strong connections between the hippocampal genes, neurotransmitters, and gut microbiota affected by L-tyrosine. The transplantation of microbiota from L-tyrosine-treated mice to VPA-induced ASD mice recipients recapitulated the preventive and protective effects of L-tyrosine on autistic behavior disorders. These findings suggest that dietary L-tyrosine may represent a viable, effective treatment option for managing the physiological and behavioral deficits associated with ASD.

01 Jun 2025·Gold Bulletin

Simple process for the recovery of gold metals and palladium(II) compound from aqua regia etching solutions of printed circuit boards by chemical reduction and precipitation

Author: Nguyen, Thi Nhan Hau ; Lee, Man Seung

Printed circuit boards (PCBs) contain precious metals like gold and palladium.After pre-treatment, PCBs are dissolved with aqua regia to recover precious metals.Reduction and precipitations experiments were done to recover gold metal and palladium(II) compound from PCB etching solutions which contained Au(III), Pd(II), Al(III), Cu(II), Fe(III), Ni(II), Sn(II), and Zn(II).In the first step, Au(III) ions were chem. reduced to gold metal using ascorbic acid without changing the acidity of the solutionThe optimal conditions for the reduction were 1.5 for the molar ratio of ascorbic acid to Au(III) at room temperature for 30 min.Then, PdI₂ was recovered from the filtrate by using NaI as a precipitant.The optimal conditions for this precipitation were a NaI/Pd(II) molar ratio of 7 at room temperature for 60 min.The purity of the gold metal and PdI₂ was verified by measuring the composition of the solution after dissolving with aqua regia.A simple process was proposed to recover gold metal and PdI₂ powders with 99.9% purity from the etching solutions of PCBs at room temperature

01 Jun 2025·Environmental Pollution

Diurnal impacts of tire wear and waste burning on fine particulate matter concentrations in a metropolitan area

Article

Author: Schauer, James J ; Bae, Min-Suk ; Jeon, Hajeong ; Oh, Sea-Ho ; Park, Chaehyeong ; Yu, Geun-Hye

The ecological toxicity of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), an antioxidant used in tires, has been investigated in studies of fine particulate matter (PM_2.5) related to public health. Using samples collected in 3-h intervals from January to March 2024 (as part of the Asia-AQ campaign in Northeast Asia.), this study identifies 6PPD-quinone (6PPD-Q) along with terephthalic acid from waste polyethylene terephthalate using liquid chromatography-time-of-flight tandem mass spectrometry. The vehicle-tire wear (2 %) and tailpipe emissions (6 %), as well as wood burning (19 %) and waste food burning (9 %) were identified in PM_2.5. Overall, waste burning contributed 28 % to PM_2.5. Other identified sources included secondary sulfate and secondary nitrate. 6PPD-Q from tire wear exhibited concentrations peaking during daytime. Titanium emissions, used as a proxy for brake wear, were found to contain redox-active metals for 6PPD-Q. Terephthalic acid, levoglucosan, and cholesterol displayed strong diurnal patterns, with significant nighttime contributions from waste burning. These findings emphasize the substantial impact of primary sources on PM_2.5 concentrations. Additionally, they underscore the importance of high temporal resolution for accurate source identification and highlight the urgent need to address tire- and waste-related pollution in urban environments.

100 Deals associated with Mokpo National University

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100 Translational Medicine associated with Mokpo National University

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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