Last update 20 Mar 2025

MB-CART2019.1

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Anti-CD20-anti-CD19 CAR T cells, CD20-CD19-targeting CAR T Cells, DALY II USA
+ [2]
Target
CD19 x CD20
Action
inhibitors
Mechanism
CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), CD20 inhibitors(B-lymphocyte antigen CD20 inhibitors), T lymphocyte replacements
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [2]
Active Indication
Diffuse Large B-Cell LymphomaDiffuse large B-cell lymphoma recurrentDiffuse large B-cell lymphoma refractory+ [9]
Inactive Indication-
Originator Organization
Miltenyi Biotec, Inc.
Active Organization
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartupMiltenyi Biotec BV & Co. KG
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationPRIME (European Union)
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Related

4
Clinical Trials associated with MB-CART2019.1
NCT06508775
/ RecruitingNot Applicable
Long-Term Follow-up of Patients Treated With Miltenyi Cell and Gene Therapies
NCT04844866
/ Active, not recruitingPhase 2
A Pivotal Phase II Randomised, Multi-centre, Open-label Study to Evaluate the Efficacy and Safety of MB-CART2019.1 Compared to SoC Therapy in Participants With r/r DLBCL, Who Are Not Eligible for HDC and ASCT
NCT04792489
/ RecruitingPhase 2
A Multi-center Single Arm Phase II Study to Evaluate the Safety and Efficacy of Genetically Engineered Autologous Cells Expressing Anti-CD20 and Anti-CD19 Specific Chimeric Antigen Receptor in Subjects With Relapsed and/or Refractory Diffuse Large B Cell Lymphoma
100 Clinical Results associated with MB-CART2019.1
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100 Translational Medicine associated with MB-CART2019.1
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100 Patents (Medical) associated with MB-CART2019.1
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100 Deals associated with MB-CART2019.1
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Large B-Cell LymphomaPhase 2
Czechia
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
18 Aug 2021
Diffuse Large B-Cell LymphomaPhase 2
Lithuania
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
18 Aug 2021
Diffuse large B-cell lymphoma recurrentPhase 2
United States
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 May 2021
Diffuse large B-cell lymphoma refractoryPhase 2
United States
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 May 2021
Primary Central Nervous System LymphomaPhase 2
United States
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 May 2021
Chronic Lymphocytic LeukemiaPhase 2
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 Feb 2019
High grade B-cell lymphomaPhase 2
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 Feb 2019
Mediastinal large B-cell lymphomaPhase 2
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 Feb 2019
Small Lymphocytic LymphomaPhase 2
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 Feb 2019
T-cell/histiocyte rich large B-cell lymphomaPhase 2
Germany
Miltenyi Biomedicine GmbHMiltenyi Biomedicine GmbHStartup
25 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03870945 (ASH 12020 | ASH 22020)
ManualManual
Phase 1
B-Cell Lymphoma
CD19 Positive | CD20 Positive
12
(blxqtghlle) = CRS grade 1 occurred in 3/6 patients on DL1 and DL2 each, and CRS grade 2 in 2 patients on DL2. ntpuqmvfxx (sgqnzsjedp )
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Positive
05 Nov 2020
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Approval

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Regulation

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