Last update 25 Mar 2025

Thiostrepton

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
RSO-021
Action
inhibitors
Mechanism
50S subunit inhibitors(50S ribosomal subunit inhibitors), FOXM1 inhibitors(forkhead box M1 inhibitors), PRDX3 inhibitors(peroxiredoxin 3 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (European Union)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Malignant Pleural EffusionPhase 2
United Kingdom
31 Mar 2022
Malignant Pleural EffusionPhase 2
United Kingdom
31 Mar 2022
Malignant Pleural MesotheliomaPhase 2
United Kingdom
31 Mar 2022
Metastatic breast cancerPhase 2
United Kingdom
-
Non-Small Cell Lung CancerPhase 2
United Kingdom
-
Ovarian CancerPhase 2
United Kingdom
-
Adenocarcinoma of LungPhase 1
United Kingdom
30 Jan 2022
Hormone receptor positive HER2 negative breast cancerPreclinical
Taiwan Province
17 Feb 2025
Peritoneal NeoplasmsPreclinical
United Kingdom
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
15
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Positive
24 May 2024
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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