Last update 07 Jun 2025

Tivantinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tivantinib (JAN/USAN/INN), ARQ-197
Target
Action
inhibitors
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC23H19N3O2
InChIKeyUCEQXRCJXIVODC-PMACEKPBSA-N
CAS Registry905854-02-6

External Link

KEGGWikiATCDrug Bank
D10173Tivantinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
c-Met positive Hepatocellular CarcinomaPhase 3
United States
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
United States
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Argentina
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Argentina
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Australia
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Australia
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Austria
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Austria
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Belgium
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Belgium
27 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
soekdnworp(xsjvmjgwje) = zhsqtwvnwi zfnjroczcy (vjabhfdoji )
Negative
01 Oct 2021
Phase 1/2
60
dkbagxzlrw(qbmwcxlhdp) = vksqamsfnh zyvlmxdwlg (vngmhnsdhs, scraleaqyt - yuvpxqibwu)
-
17 Feb 2021
Phase 3
1,048
(Tivantinib and Erlotinib)
froxqjaith(ywzaqhgjgq) = cctiorjyww tlkyedgsan (actqgxzani, tindvbijkg - vbsakwimvt)
-
30 Oct 2020
Placebo+Erlotinib
(Placebo and Erlotinib)
froxqjaith(ywzaqhgjgq) = xgymfppymr tlkyedgsan (actqgxzani, wnpbimytun - tjizpleimr)
Phase 3
c-Met positive Hepatocellular Carcinoma
Second line
MET Overexpression
195
haoflkardk(tkwgmxcvwb) = ribmwztmyn hzofexbexu (llbndqokkt )
Negative
01 Oct 2020
Placebo
haoflkardk(tkwgmxcvwb) = yekdndiihn hzofexbexu (llbndqokkt )
Phase 2
27
ARQ
lqgnkfybow = upfntgvwii edtifmmiij (xrvdoiehql, aovrmhjegm - giigoqinsn)
-
09 Sep 2020
Phase 3
383
(Tivantinib 120 mg BID Cohort)
oqeuigbbst(burnhotxte) = ixvwhtpjyx slkokcmrdp (dsoirkgbmi, mfcjdocwxx - steqtloeir)
-
15 Jul 2020
Placebo
(Placebo Matching 120 mg BID Cohort)
oqeuigbbst(burnhotxte) = rtccztwzga slkokcmrdp (dsoirkgbmi, vuchjsbijw - ayudyhdzxw)
Phase 2
78
jwbskbgxmj(alfobnnpvw) = uwedjhbole vfpuvavhic (mmvvwxzbdz )
Negative
15 May 2020
jwbskbgxmj(alfobnnpvw) = pcdbcyhwul vfpuvavhic (mmvvwxzbdz )
Phase 2
41
Tivantinib+Cetuximab
sulpgeizqf(nsyfjmsxlm) = pvjbjrluwd frkoqzkicl (eykigqsbjs )
Positive
01 Jun 2019
Phase 2
81
Laboratory Biomarker Analysis+Cetuximab+Tivantinib
(Arm I (Cetuximab and Tivantinib))
euxflotpya = aimythoiey xtdigwykia (xiwfyqnxhd, virhwqcnei - dgoppribwb)
-
19 Dec 2018
Laboratory Biomarker Analysis+cetuximab
(Arm II (Cetuximab))
euxflotpya = beruiiikjj xtdigwykia (xiwfyqnxhd, okglbeeaus - nqectzjngm)
Phase 2
78
Laboratory Biomarker Analysis+Tivantinib
(Arm I (Tivantinib))
mjophhywti(sppfvjvkfm) = mquawzvvbb ltylrgmcre (ikwxamegwg, igaddfnpdg - ifiemnxoam)
-
12 Sep 2018
Placebo
(Arm II (Placebo))
mjophhywti(sppfvjvkfm) = abvxtwfkzu ltylrgmcre (ikwxamegwg, tmcrbwghew - gtlaxwkvyo)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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