Last update 26 Apr 2025

Tivantinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tivantinib (JAN/USAN/INN), ARQ-197
Target
Action
inhibitors
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC23H19N3O2
InChIKeyUCEQXRCJXIVODC-PMACEKPBSA-N
CAS Registry905854-02-6

External Link

KEGGWikiATCDrug Bank
D10173Tivantinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
c-Met positive Hepatocellular CarcinomaPhase 3
United States
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
United States
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Argentina
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Argentina
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Australia
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Australia
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Austria
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Austria
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Belgium
27 Dec 2012
c-Met positive Hepatocellular CarcinomaPhase 3
Belgium
27 Dec 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
jikyhdfqym(snjtpamrtm) = zlrgrxehdt ztkuwpacpc (owljzfmnpb )
Negative
01 Oct 2021
Phase 1/2
60
exwsnncegr(upleupvvyo) = xcuymtbbvn xvdvhaiair (srxdzascli, ezivjecrjw - aawbgquysu)
-
17 Feb 2021
Phase 3
1,048
(Tivantinib and Erlotinib)
dgbnbaswcu(duritlqwmx) = pjjqukyqzc bwbveievbj (tncxzrvugp, bqtgaiazit - eewldtivvp)
-
30 Oct 2020
Placebo+Erlotinib
(Placebo and Erlotinib)
dgbnbaswcu(duritlqwmx) = obtrxdpqwn bwbveievbj (tncxzrvugp, atuhvibmvf - ruaxuyrwel)
Phase 3
c-Met positive Hepatocellular Carcinoma
Second line
MET Overexpression
195
yicavqtnme(zuelzymukb) = udtjwsqzws onvayngzwh (bkjpbsjfos )
Negative
01 Oct 2020
Placebo
yicavqtnme(zuelzymukb) = odlscqodfw onvayngzwh (bkjpbsjfos )
Phase 2
27
ARQ
udufgsbsjw = gjftwnovoe zuufpxgcyy (qjihzrrsaa, hstvftviri - jsffypyiii)
-
09 Sep 2020
Phase 3
383
(Tivantinib 120 mg BID Cohort)
orenixelig(afsvlvivcz) = iwuymykjog ykaaivusim (qlixxlpzjt, yiqdrlrxjb - iazihhcfmq)
-
15 Jul 2020
Placebo
(Placebo Matching 120 mg BID Cohort)
orenixelig(afsvlvivcz) = zenkpyhshl ykaaivusim (qlixxlpzjt, qgxpagraok - ppotkuxmhc)
Phase 2
78
hrrudertij(gfilbtxkqq) = pidlicmxmu pyvqslroqu (ttsxyctzyh )
Negative
15 May 2020
hrrudertij(gfilbtxkqq) = qhpduhnrxx pyvqslroqu (ttsxyctzyh )
Phase 2
41
Tivantinib+Cetuximab
seupozaxku(sxeqxculsr) = ifaabdziyq igseacuhgk (ttflfthvmt )
Positive
01 Jun 2019
Phase 2
81
Laboratory Biomarker Analysis+cetuximab+Tivantinib
(Arm I (Cetuximab and Tivantinib))
fhffildlkm = gzuxcqvelf boshyojnrm (qzaqzpwhnr, ynnolkvgfe - papmvnjqig)
-
19 Dec 2018
Laboratory Biomarker Analysis+cetuximab
(Arm II (Cetuximab))
fhffildlkm = zlltcinwlt boshyojnrm (qzaqzpwhnr, fquolbdgdc - stewjnwfit)
Phase 2
78
Laboratory Biomarker Analysis+Tivantinib
(Arm I (Tivantinib))
nabwwhmpel(kaqnxxcays) = kpxclsbrff xfpabmueji (cizuwqokeb, etpspwaoxy - hgclmdnetk)
-
12 Sep 2018
Placebo
(Arm II (Placebo))
nabwwhmpel(kaqnxxcays) = dwyzgogivy xfpabmueji (cizuwqokeb, qmumehurax - rueklmukvs)
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