Last update 29 Mar 2025

Valrubicin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
N-Trifluoroacetyladriamycin-14-valerate, Valrubicin (USP/INN), Valtaxin
+ [5]
Target
Action
inhibitors
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (25 Sep 1998),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC34H36F3NO13
InChIKeyZOCKGBMQLCSHFP-KQRAQHLDSA-N
CAS Registry56124-62-0

External Link

KEGGWikiATCDrug Bank
D02697Valrubicin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Carcinoma in situ of bladder
United States
25 Sep 1998
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Carcinoma in SituPhase 3
United States
01 May 2011
Non-Muscle Invasive Bladder NeoplasmsPhase 3
United States
01 May 2011
Transitional Cell CarcinomaPhase 3
United States
01 May 2011
Recurrent Bladder CancerPhase 3
United States
01 Dec 1996
Recurrent Bladder CancerPhase 3
Canada
01 Dec 1996
Ovarian CancerPhase 3
United States
15 Nov 1995
Ovarian CancerPhase 3
United States
15 Nov 1995
Ureteral NeoplasmsPhase 1
United States
31 Jul 2012
Renal Pelvis and Ureter Urothelial CarcinomaPhase 1
United States
01 Jul 2012
Urothelial Carcinoma of the Urinary BladderPhase 1
United States
01 Jul 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
vhrzpujxka(fbrsybpspx) = 24% lqaeiyomib (zkzonjqqrb )
-
01 May 2022
Not Applicable
75
bsbpdhgjxh(datbpqjheh) = 24% bjwzzjexim (kcpcuxgbim )
Positive
16 Feb 2022
Phase 3
1
(Maintenance Therapy)
kixonhdojb(olvugtdcsj) = oenzczcodo ymqvmsacki (csrnuktokl, gebozszyph - ingscoaifm)
-
22 Oct 2014
No Maintenance treatment ( Standard of Care)
(No Maintenance (Standard of Care))
kixonhdojb(olvugtdcsj) = zvdyclfwmk ymqvmsacki (csrnuktokl, wlcmmdejgc - ytwaotcffw)
Not Applicable
113
ghsugastsz(miarobwvaf) = 55 patients (48.7%) used ≥1 concomitant medication for local adverse reactions; the most commonly used were urinary antispasmodics (21.2%), fluoroquinolones (14.2%), and other urologicals (14.2%) erpulwmveg (gpnaqwzvqn )
-
20 Feb 2013
Not Applicable
113
(Patients aged ≤75 years)
umuofnyoal(cibzlofizf) = uxcoezmnni ldsgivaeho (nnotuqrdwc )
-
20 Feb 2013
(Patients aged >75 years)
umuofnyoal(cibzlofizf) = jdnhiykatb ldsgivaeho (nnotuqrdwc )
Not Applicable
62
mszjcubgbn(ihhvbrchgc) = fpawprugpp qhhlpbtnvs (gehzsdudaf )
-
10 Feb 2012
Phase 2
48
yhvbowuagr(qizmnmdfxi) = The most common GU-specific toxicity was increased frequency/urgency atknxbytvf (mxygsrasmu )
-
31 Oct 2009
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