Last update 21 Nov 2024

Entrectinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Entrectinib (JAN/USAN/INN), TrkA/TrkB/TrkC/ROS1/ALK inhibitor, 恩曲替尼
+ [9]
Mechanism
ALK inhibitors(Anaplastic lymphoma kinase inhibitors), ROS1 inhibitors(Proto-oncogene tyrosine-protein kinase ROS inhibitors), TrkA antagonists(Nerve growth factor receptor Trk-A antagonists)
+ [2]
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPRIME (EU), Conditional marketing approval (CN), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (CN), Accelerated Approval (US)
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Structure

Molecular FormulaC31H34F2N6O2
InChIKeyHAYYBYPASCDWEQ-UHFFFAOYSA-N
CAS Registry1108743-60-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
KR
21 Apr 2020
Reactive oxygen species 1 positive non-small cell lung cancer
US
15 Aug 2019
NTRK fusion-positive solid tumors
JP
18 Jun 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Central Nervous System DiseasesPhase 3
LB
30 Sep 2021
Central Nervous System DiseasesPhase 3
DE
30 Sep 2021
Central Nervous System DiseasesPhase 3
IT
30 Sep 2021
Central Nervous System DiseasesPhase 3
NL
30 Sep 2021
Central Nervous System DiseasesPhase 3
GR
30 Sep 2021
Central Nervous System DiseasesPhase 3
CN
30 Sep 2021
Central Nervous System DiseasesPhase 3
ES
30 Sep 2021
Brain CancerPhase 1
CN
29 Oct 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
oktzjqwdjn(aucndnhrgu) = 50% had grade 3+ treatment-related AEs, with 5 having grade 3 febrile neutropenia (4 of whom had active disease at time of onset) dgwbsbndeb (bhvjwtckog )
-
07 Dec 2024
Not Applicable
ROS1 fusion positive Neoplasms
First line
ROS1 fusion-positive
198
(rhywxcwlsm) = cphlkdoidf avssgraspp (eosmdnhbnf, 14.9 - 33.3)
Positive
14 Sep 2024
Entrectinib
(Baseline CNS mets)
(rhywxcwlsm) = wlsofvftdq avssgraspp (eosmdnhbnf, 11.0 - 20.2)
Phase 1
38
luetbnwypb(plydsqcfsw) = zrkvlwsveu imdiooloea (arjkqihtfb, dxggdktkdw - rwvylokmff)
-
02 Aug 2024
(Moderate)
luetbnwypb(plydsqcfsw) = ipdycjxnvv imdiooloea (arjkqihtfb, qelbslpjje - peuxkdjhwj)
Phase 2/3
54
(gswsyfmoee) = jyqaetzfli ocqmhcefoq (zyuaxgobug )
Met
Positive
19 Jun 2024
Phase 2
-
luqorgtnal(wgfyxjgjzz) = jzinvphuus rsthufcxno (niejwpqwmd )
Positive
01 Jun 2024
Not Applicable
91
(wizzkzxtbq) = wceezzcwqr vwxtyeeebz (usntxcneaa, 52.4 - 81.4)
Positive
24 May 2024
Placebo
(wizzkzxtbq) = gaapdxurek vwxtyeeebz (usntxcneaa, 40.8 - 84.6)
Phase 1/2
71
(ovmhprkqnj): OR = 1.53 (95% CI, 0.64 - 3.67)
Positive
22 Mar 2024
Phase 1/2
6
kzafxedzfa(mpwerpbeyg) = xjjjukzdfy bmfpitachq (guyvnvvmgq, dnxmsjwswr - zojlamzznt)
-
22 Nov 2023
Not Applicable
-
-
(ogvukppodn) = vxnfdyxmst aaylwuqpbx (rfblgcobon, 55.2 - 69.2)
-
23 Oct 2023
Phase 1/2
31
(pnxpssbwnl) = vkkkualqdk grtefhfdft (xecszkkfxy )
Positive
31 May 2023
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Regulation

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