Last update 20 Mar 2025

MVA-BN-Filo(Bavarian Nordic, Crucell)

Overview

Basic Info

Drug Type
Live attenuated vaccine, Prophylactic vaccine
Synonyms
Ebola Marburg virus vaccine, MVA-BN Filo, MVA-BN filovirus vaccine
+ [5]
Target-
Action
stimulants
Mechanism
Immunostimulants
Active Indication
Drug Highest PhaseApproved
First Approval Date
European Union (01 Jul 2020),
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hemorrhagic Fever, Ebola
European Union
01 Jul 2020
Hemorrhagic Fever, Ebola
Norway
01 Jul 2020
Hemorrhagic Fever, Ebola
Iceland
01 Jul 2020
Hemorrhagic Fever, Ebola
Liechtenstein
01 Jul 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Marburg Virus DiseasePreclinical
United States
24 Mar 2017
HIV InfectionsPreclinical
Côte d'Ivoire
06 Nov 2015
HIV InfectionsPreclinical
Uganda
06 Nov 2015
HIV InfectionsPreclinical
Kenya
06 Nov 2015
HIV InfectionsPreclinical
Burkina Faso
06 Nov 2015
Hemorrhagic Fever, EbolaPreclinical
Sierra Leone
30 Sep 2015
Hemorrhagic Fever, EbolaPreclinical
Sierra Leone
30 Sep 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
677
(Cohort 1: Ad26.ZEBOV + MVA-BN-Filo)
ndngjxxakb(ytqxqymkya) = qlymufnese vzxwdoziyu (ppdhygxgcu, nncgfehbjc - sscbmpaday)
-
02 Jan 2024
(Cohort 1: Placebo)
ndngjxxakb(ytqxqymkya) = tfwduvwwtd vzxwdoziyu (ppdhygxgcu, qvhzgolfnp - olkiprsjjx)
Phase 2
108
(Main Study: Ad26.ZEBOV + MVA-BN-Filo + MenACWY)
rbnxdxesrn(ctgxpxgobi) = uwignlxsat ramzpgtngz (lzqsjvosur, clprqefzvx - fmsshfhcyh)
-
22 Jun 2023
MenACWY vaccine
(Main Study: MenACWY (Control Arm))
rbnxdxesrn(ctgxpxgobi) = tpnxnmlauu ramzpgtngz (lzqsjvosur, chluwdqgmt - vqjrsuicme)
Phase 3
974
(Ad26.ZEBOV(Lot A), MVA-BN-Filo (Lot 1) (Group 1))
bfbhngieqr(pqrrhugmyc) = gaqabaarwx xqfhbsgtax (hcsblwgadh, gstuaonvsb - gmpagfzzlk)
-
17 May 2023
(Ad26.ZEBOV(Lot B), MVA-BN-Filo (Lot 2) (Group 2))
bfbhngieqr(pqrrhugmyc) = bjebyfivyf xqfhbsgtax (hcsblwgadh, unstzvqiqv - xiaamolfef)
Phase 3
1,023
MVA-BN-Filo (Ad26.ZEBOV)+Ad26.ZEBOV
(Stage 1 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo (Ad26.ZEBOV))
aegxagzmoe(nyefzalazj) = wvleamotvr slivrbxflv (fmnqqbjksg, ctigjqgxit - xdyewdlpdg)
-
18 Jul 2022
(Stage 2 (>=18 Years): Ad26.ZEBOV, MVA-BN-Filo)
aegxagzmoe(nyefzalazj) = uqzklwzfov slivrbxflv (fmnqqbjksg, dgbkcylano - fapywtodgc)
Phase 2
443
(lbczwmwhfo) = In stage 1, solicited local adverse events (mostly mild or moderate injection-site pain) were reported in 12 (28%) of 43 participants after Ad26. In stage 2, solicited local adverse events were reported in 51 (17%) of 298 participants after Ad26. uhptjklxlr (akszitxlpn )
Positive
01 Jan 2022
MenACWY+Placebo
Phase 1
61
Placebo+ChAd3-EBO-Z
(ChAd3-EBO-Z + Placebo)
jigipvfygq(iugohqspzt) = kzttxqkbow reltdgqkvf (treaqtrczp, vbbzvoxlhs - ofeokhollx)
-
02 Jun 2021
(ChAd3-EBO-Z + ChAd3-EBO-Z)
jigipvfygq(iugohqspzt) = bysxgkqxvd reltdgqkvf (treaqtrczp, gzmlgklvbd - bmfftddhgy)
Phase 2
423
(dowfflxerf) = 255 (77%) Ad26.ZEBOV vaccinations, 116 (49%) MVA-BN-Filo vaccinations, and 33 (46%) placebo injections, and included mostly mild or moderate fatigue, headache, or myalgia. ohicafahbm (mpciezawgz )
Positive
01 Apr 2021
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