This phase I/II trial tests the safety, side effects and best dose of a combination therapy (niraparib and selenium) in treating patients with BRCA negative ovarian cancer that has come back (recurrent) and does not respond to platinum based therapy (platinum resistant). Selenium is a form of the trace element with potential antineoplastic activity which may help block the formation of growths that may become cancer. Niraparib is in a class of medications called poly (ADP-ribose) polymerase inhibitors. It works by killing cancer cells and helps maintain the response of certain types of ovarian, fallopian tube and peritoneal cancers. Giving selenium and niraparib may kill more cells in patients with ovarian cancer.

Start Date18 Jul 2024

Sponsor / Collaborator

City of Hope National Medical Center

[+1]

NCT06362005 / Not yet recruitingPhase 4IIT

The Efficacy of Selenium as an Alternative or Complementary Topical Treatment of Oral Lichen Planus (Randomized Clinical Trial)

evaluate clinically and biochemically the efficacy of topically applied selenium as complementary or alternative to triamcinolone acetonide 0.1% and tacrolimus 0.1% in patients with oral lichen planus.

Start Date01 Jul 2024

Sponsor / Collaborator

Al-Azhar University

ChiCTR2400084063 / SuspendedEarly Phase 1IIT

Effects of selenium nutritional supplement of glucose,nutritional status, and clinical outcome among type 2 diabetes patients

Start Date10 May 2024

Sponsor / Collaborator

Peking Union Medical College Hospital

100 Clinical Results associated with Selenium

100 Translational Medicine associated with Selenium

100 Patents (Medical) associated with Selenium

13,802

Literatures (Medical) associated with Selenium

01 Dec 2024·Cellular and molecular life sciences : CMLS

Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc

Article

Author: Li, Yuhua ; Vasilev, Krasimir ; Cheng, Lei ; Zhu, Xuetao ; Jia, Chunwang ; Geng, Ziwen ; Xiang, Ziqian ; Liu, Xinyu ; Zhou, Shuanhu ; Gao, Yuan ; Liu, Long ; Wang, Shaoyi ; Wang, Zihao ; Yu, Ruixuan ; Zhang, Pengfei ; Liu, Kaiwen ; Zhao, Yunpeng ; Liu, Zhicheng

Abstract:

Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative disorders and imposes places heavy medical and economic burdens on individuals and society. Mechanical overloading applied to the intervertebral disc (IVD) has been widely recognized as an important cause of IVDD. Mechanical overloading-induced chondrocyte ferroptosis was reported, but the potential association between ferroptosis and mechanical overloading remains to be illustrated in nucleus pulposus (NP) cells. In this study, we discovered that excessive mechanical loading induced ferroptosis and endoplasmic reticulum (ER) stress, which were detected by mitochondria and associated markers, by increasing the intracellular free Ca2+ level through the Piezo1 ion channel localized on the plasma membrane and ER membrane in NP cells. Besides, we proposed that intracellular free Ca2+ level elevation and the activation of ER stress are positive feedback processes that promote each other, consistent with the results that the level of ER stress in coccygeal discs of aged Piezo1-CKO mice were significantly lower than that of aged WT mice. Then, we confirmed that selenium supplementation decreased intracellular free Ca2+ level by mitigating ER stress through upregulating Selenoprotein K (SelK) expression. Besides, ferroptosis caused by the impaired production and function of Glutathione peroxidase 4 (GPX4) due to mechanical overloading-induced calcium overload could be improved by selenium supplementation through Se-GPX4 axis and Se-SelK axis in vivo and in vitro, eventually presenting the stabilization of the extracellular matrix (ECM). Our findings reveal the important role of ferroptosis in mechanical overloading-induced IVDD, and selenium supplementation promotes significance to attenuate ferroptosis and thus alleviates IVDD, which might provide insights into potential therapeutic interventions for IVDD.

01 May 2024·Food microbiology

Microflora structure and functional capacity in Tibetan kefir grains and selenium-enriched Tibetan kefir grains: A metagenomic analysis

Article

Author: Yue, Tianli ; Wang, Zhouli ; Yang, Jinyi ; Yuan, Yahong ; Han, Weiyu ; Wang, Huijuan ; Guo, Xinyuan ; Chen, Ke ; Zeng, Xuejun

Tibetan kefir grains (TKGs) are a complex protein-lipid-polysaccharide matrix composed of various microorganisms. Microorganisms have the benefit of being effective, secure, and controllable when used for selenium enrichment. In this study, selenium-enriched Tibetan kefir grains (Se-TKGs) were made, and the microbiology composition was analyzed through a metagenomic analysis, to explore the influence of selenium enrichment. The microbial composition of TKGs and Se-TKGs, as well as the probiotic species, quorum sensing system (QS) and functional genes were compared and evaluated. Lactobacillus kefiranofaciens was the most abundant microbial species in both communities. Compared with TKGs, Se-TKGs had a much higher relative abundance of acetic acid bacteria. Lactobacillus helveticus was the most common probiotic species both in TKGs and Se-TKGs. Probiotics with antibacterial and anti-inflammatory properties were more abundant in Se-TKGs. QS analysis revealed that Se-TKGs contained more QS system-associated genes than TKGs. Moreover, Kyoto Encyclopedia of Genes and Genomes analysis revealed that the pathway for human disease ko01501 had the greatest relative abundance in both TKGs and Se-TKGs. Compared with TKGs, Se-TKGs demonstrated a greater relative abundance of different drug resistance-related metabolic pathways. Additionally, linear discriminant analysis effect size was used to examine the biomarkers responsible for the difference between the two groups. In this study, we focused on the microbiological structure of TKGs and Se-TKGs, with the aim of establishing a foundation for a more thorough investigation of Se-TKGs and providing a basis for exploring potential future use.

01 May 2024·Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

The influence of serum selenium in differential epigenetic and transcriptional regulation of CPT1B gene in women with obesity

Article

Author: Watanabe, Lígia Moriguchi ; Wolf, Leticia Santana ; Plaça, Jessica Rodrigues ; Noma, Isabella Harumi Yonehara ; Júnior, Fernando Barbosa ; da Silva Rodrigues, Guilherme ; Pereira, Vanessa Aparecida Batista ; de Souza, Vanessa Cristina Oliveira ; Noronha, Natalia Yumi ; de Oliveira, Cristiana Cortes ; de Souza Pinhel, Marcela Augusta ; Nonino, Carla Barbosa

INTRODUCTION:

The increasing prevalence of obesity has become a major health problem worldwide. The causes of obesity are multifactorial and could be influenced by dietary patterns and genetic factors. Obesity has been associated with a decrease in micronutrient intake and consequently decreased blood concentrations. Selenium is an essential micronutrient for human health, and its metabolism could be affected by obesity, especially severe obesity. This study aimed to identify differential methylation genes associated with serum selenium concentration in women with and without obesity.

METHODOLOGY:

Thirty-four patients were enrolled in the study and divided into two groups: Obese (Ob) n = 20 and Non-Obese (NOb) n = 14, according to the Body Mass Index (BMI). Anthropometry, body composition, serum selenium, selenium intake, and biochemical parameters were evaluated. DNA extraction and bisulfite conversion were performed to hybridize the samples on the 450k Methylation Chip Infinium Beadchip (Illumina). Bioinformatics analysis was performed using the R program and the Champ package. The differentially methylated regions (DMRs) were identified using the Bumphunter method. In addition, logarithmic conversion was performed for the analysis of serum selenium and methylation.

RESULTS:

In the Ob group, the body weight, BMI, fat mass, and free fat mass were higher than in the NOb group, as expected. Interestingly, the serum selenium was lower in the Ob than in the NOb group without differences in selenium intake. One DMR corresponding to the CPT1B gene, involved in lipid oxidation, was related to selenium levels. This region was hypermethylated in the Ob group, indicating that the intersection between selenium deficiency and hypermethylation could influence the expression of the CPT1B gene. The transcriptional analysis confirmed the lower expression of the CPT1B gene in the Ob group.

CONCLUSION:

Studies connecting epigenetics to environmental factors could offer insights into the mechanisms involving the expression of genes related to obesity and its comorbidities. Here we demonstrated that the mineral selenium might play an essential role in lipid oxidation via epigenetic and transcriptional regulation of the CPT1B gene in obesity.

News (Medical) associated with Selenium

21 Feb 2024

·www.sciencedaily.com

Toxic elements found in stranded whales, dolphins over 15 years

Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples collected from 90 whales and dolphins stranded in Georgia and Florida from 2007 to 2021. Whales and dolphins get their nutrients and essential elements through their diet. While eating fish, squid, octopus, crustaceans and other marine mammals, they are also exposed to heavy metal contaminants. Elevated levels of toxins have been found in stranded dolphins and whales along the Southeastern Coast of the United States. Monitoring toxic contaminants in these stranded marine animals, which serve as important sentinels of environmental contamination, and whose health may be linked to human health, is vital. Yet, data remain sparse on how specific elements are distributed within an animal's body, especially for many rarely encountered species, and how toxicant levels relate to its sex, breed, age and other demographic factors. A study led by Florida Atlantic University's Harbor Branch Oceanographic Institute in collaboration with a team of scientists, evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples collected from 90 whales and dolphins stranded in Georgia and Florida from 2007 to 2021. Researchers analyzed 319 samples from nine species for concentrations of seven essential (cobalt, copper, iron, manganese, molybdenum, selenium, zinc) and five non-essential (arsenic, cadmium, lead, mercury, thallium) elemental analytes. Species in the study all occupied high and similar trophic levels and consumed a mixture of cephalopods and fishes. Results of the study, published in the journal Cell Press: Heliyon, showed that Risso's dolphins (Grampus griseus) and short-finned pilot whales (Globicephala macrorhynchus) had the highest median concentrations of mercury, cadmium and lead, while dwarf sperm whales (Kogia sima) had the lowest. Adult pygmy and dwarf sperm whales that stranded during 2019 to 2021 had higher concentrations of arsenic, copper, iron, lead, manganese, selenium, thallium and zinc compared to those that stranded during 2010 to 2018, suggesting an increasing risk of exposure over time. "When we separated phylogenetic groups into age classes and compared median concentrations of heavy metals in specific tissue types between adult specimens of species, we found some interesting trends," said Annie Page, D.V.M., Ph.D., senior author, an associate research professor and clinical veterinarian, FAU Harbor Branch. The highest concentrations of many elements (e.g., cadmium, cobalt, copper, manganese, molybdenum, thallium, zinc) were in fecal samples, illustrating the usefulness of this non-invasively collected sample. Aside from fecal samples, hepatic or liver tissues had the highest concentrations of iron, manganese, mercury, molybdenum and selenium in most species; renal or kidney tissues had the highest concentrations of cadmium; skin had the highest concentrations of zinc; and copper, arsenic and lead concentrations were primarily distributed among the liver and kidneys. The lowest median concentrations of mercury and cadmium were in liver, kidney, blubber and muscle samples, with the lowest skin mercury concentration and the lowest liver lead concentration all from dwarf sperm whales. Mercury is one of the most toxic elements in marine systems and can bioaccumulate and biomagnify through marine food webs. Cetaceans are exposed to mercury and other toxic metals mostly by consuming contaminated prey items, which tend to accumulate mercury in liver, muscle and other tissues over time. "Exposure to heavy metal contaminants can result in oxidative stress, which can impair protein function, damage DNA and disrupt membrane lipids," said Page. "Heavy metal exposure has been linked to degenerative heart disease, immunodeficiency and increased parasite infestations, among other disease risks." Findings from the study provide important baseline data needed to further assess the pathophysiological mechanisms and ecotoxicological hazards associated with exposure to and accumulation of trace elements in tissues of free-ranging whales and dolphins. "Because tissue concentrations of heavy metal contaminants also vary based on an individual animal's sex, age class, trophic level and location, among other factors, it is important to first establish baseline values and then continue to monitor cetacean populations for exposure to these toxicants," said Page. Species examined in the study were pygmy sperm whales (Kogia breviceps); dwarf sperm whales; Gervais' beaked whales (Mesoplodon europaeus); Risso's dolphins; short-finned pilot whales; sperm whales (Physeter macrocephalus); melon-headed whales (Peponocephala electra); a Blainville's beaked whale (Mesoplodon densirostris); and a false killer whale (Pseudorca crassidens). Study co-authors represent FAU Harbor Branch; the U.S. Coast Guard Academy; University of Alabama at Birmingham; Hubbs-Sea World Research Institute; Blue World Research Institute; Florida Fish & Wildlife Conservation Commission, Fish & Wildlife Research Institute; and the Georgia Department of Natural Resources. This work was supported by the Florida State License Plate Program "Protect Wild Dolphins" and "Protect Florida Whales" grants (administered by the Harbor Branch Oceanographic Institute Foundation); the Link Foundation; the John H. Prescott Marine Mammal Rescue Assistance Grant; SeaWorld Busch Gardens Conservation Fund; Discover Florida Ocean's License Plate; and the Brevard County Tourism and Development Council.

Clinical ResultClinical Study

30 Oct 2023

·www.sciencedaily.com

Selenium reduces mixtures of environmental pollutants' harmful effects on health

A study in mice demonstrates that exposure to contaminating mixtures of metals and drug residue increases damage to health, and evaluates the positive effects of a diet enriched in selenium to reduce this harm. A study in mice conducted by the University of Cordoba proves that exposure to contaminating mixtures of metals and drug residue increases damage to health, and evaluates the positive effects of a diet enriched in selenium to reduce this harm People are exposed daily, through the environment and their diets, to external substances that can be harmful to their health. Metals and the residue of pharmaceuticals, for example, in high doses, contaminate water and food, creating mixtures where they can interact, with this increasing their individual toxicity. Analyzing the effects of environmental pollution on organisms is essential to develop regulations establishing maximum doses of these pollutants for people. But, what about mixtures of pollutants? What happens when, even when faced with accepted doses, the different compounds interact with each other? To understand the health effects of exposure to these "cocktails of contaminants," a team from the Biochemistry and Molecular Biology Department at the University of Cordoba, comprised of Nieves Abril, Paula Huertas, María José Prieto and Juan Jurado, evaluated, in mice, the toxicity of a mixture of contaminants that is very common in the environment and that accumulates along the food chain: a combination of metals (arsenic, cadmium, mercury) and drugs (diclofenac, flumequine). In order to determine how these compounds interacted with each other, "we studied the controlled exposure of mice to this mixture and analyzed how it affects the proteins in the liver; that is, how their liver proteostasis changes when ingesting these mixtures of contaminants for two weeks," explained Professor Nieves Abril. Their conclusion is negative: the cocktail effect creates synergy between these compounds, doing increased damage to health increase when the compounds act together. "We used a massive protein detection technique (shotgun proteomic), which allowed us to compare how the proteins of the group exposed to the mixture of contaminants were altered compared to the control group," April explained. Of the proteins affected, they selected 275 as sentinels to verify what was changing and, after computer analysis, they were able to determine the metabolic pathways that were altered and their consequences for health. These analyses revealed a disproportionate defense response having a contrary and harmful effect on the system. The researcher stressed that "although these pollutants generated oxidation in the cells separately too, when they acted together we found that the oxidation was so intense that all the antioxidant defense responses were activated continuously, without deactivating them, which ends up doing damage and causing many proteins to stop working." The analyses showed a sustained expression of the response mediated by NRF2, which is the regulator that sets in motion a good part of the antioxidant defenses, which caused a reducing stress. Selenium as hope The study also provides hope, as selenium could be a way to reduce the damage caused by exposure to these pollutants. A third group of mice were given doses of selenium, a mineral often found in vitamin supplements found in pharmacies, and proteomic analyses showed relief from the molecular damage done by the pollutants. Selenium itself is an oxidant, but in low doses it activates responses in a controlled manner, predisposing the body to better defense. With the results of this experiment, which was made possible thanks to Research Support (SCAI) and Experimental Animals (SAEX) services, knowledge of the effects of the pollutants to which society is exposed on a daily basis has been expanded, and a way has been glimpsed to reduce the damage they producethrough the use of selenium.

18 Oct 2023

·www.prnewswire.com

Chewsy Launches Multi Vitamin Essentials at The Vitamin Shoppe

The Unique Line of Candy-Like Chews Feature Vitamins, Minerals, Superfoods, and Probiotics to Support Health and Well-being NASHVILLE, Tenn., Oct. 18, 2023 /PRNewswire/ -- Chewsy, a leading provider of innovative and delicious candy style vitamin chews, is thrilled to announce an assortment of best selling chews now available for purchase at The Vitamin Shoppe. These one-of-a-kind vitamin chews deliver a complete blend of essential nutrients, bursting with juicy flavor but even juicer health benefits. Consumers no longer have to choose between effectiveness, taste, portability or affordability. Chewsy chews are bursting with juicy flavor, taste like candy and they're filled with scientifically validated nutrition. Unlike traditional gummies, Chewsy chews are individually wrapped so they stay sanitary, are easily portable and won't clump together in warm weather and are also larger to fit more nutrients in each chew, with only 3 grams of organic sugar. "We are so pleased to offer a wide array of our best selling offerings at The Vitamin Shoppe," said Chewsy Co-founder, Sean Ross, "The Vitamin Shoppe's reputation as a go-to destination for high-quality, cutting-edge supplements allows consumers to discover Chewsy's unique chew options during their shopping experiences. This partnership allows us to reach a healthy-living and wellness-oriented audience." A breadth of solutions for targeted needs are available for $22.99/30 chews: Women's Multi: This cranberry grape chew delivers a complete formula for women and is scientifically formulated with 23 nutrients and 100% daily value of 16 essential vitamins and minerals. Men's Multi: Scientifically formulated with 23 nutrients and 100% daily value for 16 essential nutrients, these naturally flavored cranberry grape chews contain saw palmetto, stinging nettle, probiotics, zinc and selenium for added men's support. Kids' Multi: A naturally flavored and tasty wild berry chew that can be taken daily. This unique supplement is designed with kids in mind and parents can rest easy knowing their children are getting the nutrition they need with 23 nutrients and only 3 grams of sugar per chew. Immune Support: Each chew contains 6 powerful Supernutrients that keep your immune system running strong, all day, every day. The chews are a naturally flavored tropical cherry and contain key vitamins and minerals including Eldermune Elderberry, Vitamin A, C, and D, Zinc, and Selenium. So Long Stress: A tropical fruit chew that supports a relaxed, focused state of mind and helps combat the acute effects of stress. Youthful Skin: This delicious raspberry lemonade flavored chew supports skin health and a more youthful appearance boasting Hyaluronic acid, grape seed extract, minerals, and essential antioxidants. Beautiful Hair: Formulated with 12 key nutrients to support hair health and strength, this chew is infused with Biotin, Goji Berry, Vitamin D, Vitamin C, and essential B vitamins. For more information about the Chewsy chews, visit Chewsychews.com or VitaminShoppe.com. About Chewsy Chews: A leading provider of high-quality chewable supplements. Chewsy chews taste like candy, but they're filled with scientifically validated nutrition. Because Chewsy chews are bigger than gummies, they can fit more nutrients in them and contain only 3 grams of sugar, and no gelatin. The chews are individually wrapped to be portable, sanitary, and mess-free in heat/warm weather. Chewsy products can be found at , Vitamin Shoppe, Amazon, Target, Sprouts, Whole Foods, CVS, and more. SOURCE Chewsy

100 Deals associated with Selenium

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Acquired Immunodeficiency Syndrome	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Cardiotoxicity	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Chagas Disease	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Chronic Disease	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
end organ damage	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Functional disorder	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Huntington Disease	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Infarction	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Keshan Disease	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008
Myocardial Infarction	Phase 3	BR	Fundação Oswaldo Cruz	31 Oct 2008

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2022	Not Applicable	toenail selenium level	-	High selenium concentration	tkztmylgds(qlmsajnmlu) = The supplementation is associated with some adverse side effects xkatgmgobj (typqvqxsym )	Negative	03 Nov 2022
				Low selenium concentration
SO044 (ERA2020)	Not Applicable	reactive oxygen species (ROS) \| miRNA-126 \| CoQ10	60	Selenium	nosxgmuhpa(thaoerhpcu) = ixhtazpfvx gbedtsohxb (ncwjrjecgl )	Positive	06 Jun 2020
AACR2018	Phase 1	Female Genital Neoplasms	-	Selenious acid/carboplatin/paclitaxel	draqimuota(uggylnrdvp) = varvynmjep yoihemnakd (yemioflcje ) View more	-	01 Jul 2018
SP238 (ERA2018)	Not Applicable	Acute Kidney Injury	120	Selenium	gqsazfufeq(sduqomfhgq) = ssngubczll utmamgrins (gyikkwutoq ) View more	Negative	18 May 2018
				selenium	gqsazfufeq(sduqomfhgq) = xehtjhqxlo utmamgrins (gyikkwutoq )
SP423 (ERA2015)	Not Applicable	Hemodialysis complication selenium levels \| T3 \| free T4 ... View more	40	SELENIUM	ttfhzikmio(meyxkwfett) = yunkidbger hoopxukdvh (cgtdkjpsgv, 11.2) View more	Positive	21 May 2015
E5597 (ASCO2014)	Not Applicable	Second Primary Neoplasms	-	Selenium	orpfoyybyt(ulzmrjwxsm) = hsklvunzva wasynukuaq (vrtjtqjgxw, 0.77 - 2.38)	-	20 May 2014
				Placebo	orpfoyybyt(ulzmrjwxsm) = mjnjzqxwzc wasynukuaq (vrtjtqjgxw )
Pubmed \| Int J Cardiol	Not Applicable	-	443	Combined supplementation of selenium and coenzyme Q10	ivggeskfsm(dyymiynpyx) = fpzewvdzxo fdoikwssfc (twbobqggef ) View more	Positive	01 Sep 2013
				selenium (Placebo)	ivggeskfsm(dyymiynpyx) = ozrurpqvrn fdoikwssfc (twbobqggef ) View more
Pubmed	Not Applicable	Hashimoto Disease	463	Selenium supplementation	ahvmazveup(sriafpsvsp): RR = 4.67 (95% CI, 1.61 - 13.5), P-Value = 0.004	-	06 Jun 2013
				Selenium
ASCO2011	Not Applicable	Neoplasms	67	Selenium supplementation	qjeyvhlros(bryazsgbbx) = ylwikicyaw tvenktbcfj (ycfmrgtbhr )	-	20 May 2011
				No selenium supplementation	qjeyvhlros(bryazsgbbx) = sekltpuhar tvenktbcfj (ycfmrgtbhr )
ISRCTN87144826 (Pubmed)	Not Applicable	Critical Illness	502	Selenium	piayrxytog(biklfglvcf): odds ratio = 0.99 (95% CI, 0.56 - 1.75)	-	17 Mar 2011
				Glutamine and Selenium

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